Abstract: This paper addresses the problem of inferring unseen cross-modal image-to-image translations between multiple modalities. We assume that only some of the pairwise translations have been seen (i.e. trained) and infer the remaining unseen translations (where training pairs are not available). We propose mix and match networks, an approach where multiple encoders and decoders are aligned in such a way that the desired translation can be obtained by simply cascading the source encoder and the target decoder, even when they have not interacted during the training stage (i.e. unseen). The main challenge lies in the alignment of the latent representations at the bottlenecks of encoder-decoder pairs. We propose an architecture with several tools to encourage alignment, including autoencoders and robust side information and latent consistency losses. We show the benefits of our approach in terms of effectiveness and scalability compared with other pairwise image-to-image translation approaches. We also propose zero-pair cross-modal image translation, a challenging setting where the objective is inferring semantic segmentation from depth (and vice-versa) without explicit segmentation-depth pairs, and only from two (disjoint) segmentation-RGB and depth-RGB training sets. We observe that a certain part of the shared information between unseen modalities might not be reachable, so we further propose a variant that leverages pseudo-pairs which allows us to exploit this shared information between the unseen modalities

Abstract: Radiomics is an emerging technique for the quantification of imaging data that has recently shown great promise for deeper phenotyping of cardiovascular disease. Thus far, the technique has been mostly applied in single-centre studies. However, one of the main difficulties in multi-centre imaging studies is the inherent variability of image characteristics due to centre differences. In this paper, a comprehensive analysis of radiomics variability under several image- and feature-based normalisation techniques was conducted using a multi-centre cardiovascular magnetic resonance dataset. 218 subjects divided into healthy (n = 112) and hypertrophic cardiomyopathy (n = 106, HCM) groups from five different centres were considered. First and second order texture radiomic features were extracted from three regions of interest, namely the left and right ventricular cavities and the left ventricular myocardium. Two methods were used to assess features’ variability. First, feature distributions were compared across centres to obtain a distribution similarity index. Second, two classification tasks were proposed to assess: (1) the amount of centre-related information encoded in normalised features (centre identification) and (2) the generalisation ability for a classification model when trained on these features (healthy versus HCM classification). The results showed that the feature-based harmonisation technique ComBat is able to remove the variability introduced by centre information from radiomic features, at the expense of slightly degrading classification performance. Piecewise linear histogram matching normalisation gave features with greater generalisation ability for classification ( balanced accuracy in between 0.78 ± 0.08 and 0.79 ± 0.09). Models trained with features from images without normalisation showed the worst performance overall ( balanced accuracy in between 0.45 ± 0.28 and 0.60 ± 0.22). In conclusion, centre-related information removal did not imply good generalisation ability for classification.

Abstract: One of the attractive characteristics of deep neural networks is their ability to transfer knowledge obtained in one domain to other related domains. As a result, high-quality networks can be trained in domains with relatively little training data. This property has been extensively studied for discriminative networks but has received significantly less attention for generative models. Given the often enormous effort required to train GANs, both computationally as well as in the dataset collection, the re-use of pretrained GANs is a desirable objective. We propose a novel knowledge transfer method for generative models based on mining the knowledge that is most beneficial to a specific target domain, either from a single or multiple pretrained GANs. This is done using a miner network that identifies which part of the generative distribution of each pretrained GAN outputs samples closest to the target domain. Mining effectively steers GAN sampling towards suitable regions of the latent space, which facilitates the posterior finetuning and avoids pathologies of other methods such as mode collapse and lack of flexibility. We perform experiments on several complex datasets using various GAN architectures (BigGAN, Progressive GAN) and show that the proposed method, called MineGAN, effectively transfers knowledge to domains with few target images, outperforming existing methods. In addition, MineGAN can successfully transfer knowledge from multiple pretrained GANs.

Abstract: While the objective of the standard supervised learning problem is to classify feature vectors, in the multiple instance learning problem, the objective is to classify bags, where each bag contains multiple feature vectors. This represents a generalization of the standard problem, and this generalization becomes necessary in many real applications such as drug activity prediction, content-based image retrieval, and others. While the existing paradigms are based on learning the discriminant information either at the instance level or at the bag level, we propose to incorporate both levels of information. This is done by defining a discriminative embedding of the original space based on the responses of cluster-adapted instance classifiers. Results clearly show the advantage of the proposed method over the state of the art, where we tested the performance through a variety of well-known databases that come from real problems, and we also included an analysis of the performance using synthetically generated data.

Abstract: When neural networks process images which do not resemble the distribution seen during training, so called out-of-distribution images, they often make wrong predictions, and do so too confidently. The capability to detect out-of-distribution images is therefore crucial for many real-world applications. We divide out-of-distribution detection between novelty detection ---images of classes which are not in the training set but are related to those---, and anomaly detection ---images with classes which are unrelated to the training set. By related we mean they contain the same type of objects, like digits in MNIST and SVHN. Most existing work has focused on anomaly detection, and has addressed this problem considering networks trained with the cross-entropy loss. Differently from them, we propose to use metric learning which does not have the drawback of the softmax layer (inherent to cross-entropy methods), which forces the network to divide its prediction power over the learned classes. We perform extensive experiments and evaluate both novelty and anomaly detection, even in a relevant application such as traffic sign recognition, obtaining comparable or better results than previous works.

Abstract: A method for automatically detecting a post-duodenal boundary in an image stream of the gastrointestinal (GI) tract. The image stream is sampled to obtain a reduced set of images for processing. The reduced set of images is filtered to remove non-valid frames or non-valid portions of frames, thereby generating a filtered set of valid images. A polar representation of the valid images is generated. Textural features of the polar representation are processed to detect the post-duodenal boundary of the GI tract.