Abstract: Brightness induction is the modulation of the perceived intensity of an area by the luminance of surrounding areas. Although striate cortex is traditionally regarded as an area mostly responsive to ensory (i.e. retinal) information,
neurophysiological evidence suggests that perceived brightness information mightbe explicitly represented in V1.
Such evidence has been observed both in anesthetised cats where neuronal response modulations have been found to follow luminance changes outside the receptive felds and in human fMRI measurements. In this work, possible neural mechanisms that ofer a plausible explanation for such phenomenon are investigated. To this end, we consider the model proposed by Z.Li (Li, Network:Comput. Neural Syst., 10 (1999)) which is based on neurophysiological evidence and focuses on the part of V1 responsible for contextual infuences, i.e. layer 2-3 pyramidal cells, interneurons, and horizontal intracortical connections. This model has reproduced other phenomena such as contour detection and preattentive segmentation, which share with brightness induction the relevant efect of contextual infuences. We have extended the original model such that the input to the network is obtained from a complete multiscale and multiorientation wavelet decomposition, thereby allowing the recovery of an image refecting the perceived intensity. The proposed model successfully accounts for well known psychophysical efects for static contexts (among them: the White's and modifed White's efects, the Todorovic, Chevreul, achromatic ring patterns, and grating induction efects) and also for brigthness induction in dynamic contexts defned by modulating the luminance of surrounding areas (e.g. the brightness of a static central area is perceived to vary in antiphase to the sinusoidal luminance changes of its surroundings). This work thus suggests that intra-cortical interactions in V1 could partially explain perceptual brightness induction efects and reveals how a common general architecture may account for several different fundamental processes emerging early in the visual processing pathway.

Abstract: Colour constancy is a perceptual mechanism that seeks to keep the colour of objects relatively stable under an illumination shift. Experiments haveshown that its effects depend on the number of colours present in the scene. We
studied categorical colour changes under different adaptation states, in particular, whether the colour categories seen under a chromatically neutral illuminant are the same after a shift in the chromaticity of the illumination. To do this, we developed the chromatic setting paradigm (2011 Journal of Vision11 349), which is as an extension of achromatic setting to colour categories. The paradigm exploits the ability of subjects to reliably reproduce the most representative examples of each category, adjusting multiple test patches embedded in a coloured Mondrian. Our experiments were run on a CRT monitor (inside a dark room) under various simulated illuminants and restricting the number of colours of the Mondrian background to three, thus weakening the adaptation effect. Our results show a change in the colour categories present before (under neutral illumination) and after adaptation (under coloured illuminants) with a tendency for adapted colours to be less saturated than before adaptation. This behaviour was predicted by a simple
affine matrix model, adjusted to the chromatic setting results.

Abstract: The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.

Abstract: In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions.
This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume.

Abstract: Image based human detection remains as a challenging problem. Most promising detectors rely on classifiers trained with labelled samples. However, labelling is a manual labor intensive step. To overcome this problem we propose to collect images of pedestrians from a virtual city, i.e., with automatic labels, and train a pedestrian detector with them, which works fine when such virtual-world data are similar to testing one, i.e., real-world pedestrians in urban areas. When testing data is acquired in different conditions than training one, e.g., human detection in personal photo albums, dataset shift appears. In previous work, we cast this problem as one of domain adaptation and solve it with an active learning procedure. In this work, we focus on the same problem but evaluating a different set of faster to compute features, i.e., Haar, EOH and their combination. In particular, we train a classifier with virtual-world data, using such features and Real AdaBoost as learning machine. This classifier is applied to real-world training images. Then, a human oracle interactively corrects the wrong detections, i.e., few miss detections are manually annotated and some false ones are pointed out too. A low amount of manual annotation is fixed as restriction. Real- and virtual-world difficult samples are combined within what we call cool world and we retrain the classifier with this data. Our experiments show that this adapted classifier is equivalent to the one trained with only real-world data but requiring 90% less manual annotations.