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Oriol Ramos Terrades, Albert Berenguel, & Debora Gil. (2022). A Flexible Outlier Detector Based on a Topology Given by Graph Communities. BDR - Big Data Research, 29, 100332.
Abstract: Outlier detection is essential for optimal performance of machine learning methods and statistical predictive models. Their detection is especially determinant in small sample size unbalanced problems, since in such settings outliers become highly influential and significantly bias models. This particular experimental settings are usual in medical applications, like diagnosis of rare pathologies, outcome of experimental personalized treatments or pandemic emergencies. In contrast to population-based methods, neighborhood based local approaches compute an outlier score from the neighbors of each sample, are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. A main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters, like the number of neighbors.
This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world and synthetic data sets show that our approach outperforms, both, local and global strategies in multi and single view settings.
Keywords: Classification algorithms; Detection algorithms; Description of feature space local structure; Graph communities; Machine learning algorithms; Outlier detectors
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David Geronimo, Angel Sappa, & Antonio Lopez. (2010). Stereo-based Candidate Generation for Pedestrian Protection Systems. In Binocular Vision: Development, Depth Perception and Disorders (189–208). NOVA Publishers.
Abstract: This chapter describes a stereo-based algorithm that provides candidate image windows to a latter 2D classification stage in an on-board pedestrian detection system. The proposed algorithm, which consists of three stages, is based on the use of both stereo imaging and scene prior knowledge (i.e., pedestrians are on the ground) to reduce the candidate searching space. First, a successful road surface fitting algorithm provides estimates on the relative ground-camera pose. This stage directs the search toward the road area thus avoiding irrelevant regions like the sky. Then, three different schemes are used to scan the estimated road surface with pedestrian-sized windows: (a) uniformly distributed through the road surface (3D); (b) uniformly distributed through the image (2D); (c) not uniformly distributed but according to a quadratic function (combined 2D-3D). Finally, the set of candidate windows is reduced by analyzing their 3D content. Experimental results of the proposed algorithm, together with statistics of searching space reduction are provided.
Keywords: Pedestrian Detection
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Reza Azad, Maryam Asadi-Aghbolaghi, Mahmood Fathy, & Sergio Escalera. (2020). Attention Deeplabv3+: Multi-level Context Attention Mechanism for Skin Lesion Segmentation. In Bioimage computation workshop.
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Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Francesca Vidal, et al. (2017). Noves perspectives en l estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals. JBR - Biologia de la Reproduccio, 73–78.
Abstract: In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation.
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C. Alejandro Parraga. (2015). Perceptual Psychophysics. In G.Cristobal, M.Keil, & L.Perrinet (Eds.), Biologically-Inspired Computer Vision: Fundamentals and Applications.
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Laura Igual, Joan Carles Soliva, Antonio Hernandez, Sergio Escalera, Xavier Jimenez, Oscar Vilarroya, et al. (2011). A fully-automatic caudate nucleus segmentation of brain MRI: Application in volumetric analysis of pediatric attention-deficit/hyperactivity disorder. BEO - BioMedical Engineering Online, 10(105), 1–23.
Abstract: Background
Accurate automatic segmentation of the caudate nucleus in magnetic resonance images (MRI) of the brain is of great interest in the analysis of developmental disorders. Segmentation methods based on a single atlas or on multiple atlases have been shown to suitably localize caudate structure. However, the atlas prior information may not represent the structure of interest correctly. It may therefore be useful to introduce a more flexible technique for accurate segmentations.
Method
We present Cau-dateCut: a new fully-automatic method of segmenting the caudate nucleus in MRI. CaudateCut combines an atlas-based segmentation strategy with the Graph Cut energy-minimization framework. We adapt the Graph Cut model to make it suitable for segmenting small, low-contrast structures, such as the caudate nucleus, by defining new energy function data and boundary potentials. In particular, we exploit information concerning the intensity and geometry, and we add supervised energies based on contextual brain structures. Furthermore, we reinforce boundary detection using a new multi-scale edgeness measure.
Results
We apply the novel CaudateCut method to the segmentation of the caudate nucleus to a new set of 39 pediatric attention-deficit/hyperactivity disorder (ADHD) patients and 40 control children, as well as to a public database of 18 subjects. We evaluate the quality of the segmentation using several volumetric and voxel by voxel measures. Our results show improved performance in terms of segmentation compared to state-of-the-art approaches, obtaining a mean overlap of 80.75%. Moreover, we present a quantitative volumetric analysis of caudate abnormalities in pediatric ADHD, the results of which show strong correlation with expert manual analysis.
Conclusion
CaudateCut generates segmentation results that are comparable to gold-standard segmentations and which are reliable in the analysis of differentiating neuroanatomical abnormalities between healthy controls and pediatric ADHD.
Keywords: Brain caudate nucleus; segmentation; MRI; atlas-based strategy; Graph Cut framework
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Manisha Das, Deep Gupta, Petia Radeva, & Ashwini M. Bakde. (2021). Optimized CT-MR neurological image fusion framework using biologically inspired spiking neural model in hybrid ℓ1 - ℓ0 layer decomposition domain. BSPC - Biomedical Signal Processing and Control, 68, 102535.
Abstract: Medical image fusion plays an important role in the clinical diagnosis of several critical neurological diseases by merging complementary information available in multimodal images. In this paper, a novel CT-MR neurological image fusion framework is proposed using an optimized biologically inspired feedforward neural model in two-scale hybrid ℓ1 − ℓ0 decomposition domain using gray wolf optimization to preserve the structural as well as texture information present in source CT and MR images. Initially, the source images are subjected to two-scale ℓ1 − ℓ0 decomposition with optimized parameters, giving a scale-1 detail layer, a scale-2 detail layer and a scale-2 base layer. Two detail layers at scale-1 and 2 are fused using an optimized biologically inspired neural model and weighted average scheme based on local energy and modified spatial frequency to maximize the preservation of edges and local textures, respectively, while the scale-2 base layer gets fused using choose max rule to preserve the background information. To optimize the hyper-parameters of hybrid ℓ1 − ℓ0 decomposition and biologically inspired neural model, a fitness function is evaluated based on spatial frequency and edge index of the resultant fused image obtained by adding all the fused components. The fusion performance is analyzed by conducting extensive experiments on different CT-MR neurological images. Experimental results indicate that the proposed method provides better-fused images and outperforms the other state-of-the-art fusion methods in both visual and quantitative assessments.
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Bart M. Ter Haar Romeny, W. Niessen, J. Weickert, P. Van Roermund, W. Van Enk, Antonio Lopez, et al. (1996). Orientation detection of trabecular bone.
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Clementine Decamps, Alexis Arnaud, Florent Petitprez, Mira Ayadi, Aurelia Baures, Lucile Armenoult, et al. (2021). DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification. BMC Bioinformatics, 22, 473.
Abstract: Quantification of tumor heterogeneity is essential to better understand cancer progression and to adapt therapeutic treatments to patient specificities. Bioinformatic tools to assess the different cell populations from single-omic datasets as bulk transcriptome or methylome samples have been recently developed, including reference-based and reference-free methods. Improved methods using multi-omic datasets are yet to be developed in the future and the community would need systematic tools to perform a comparative evaluation of these algorithms on controlled data.
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Ferran Diego, Daniel Ponsa, Joan Serrat, & Antonio Lopez. (2009). Video alignment for automotive applications.
Keywords: video alignment
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Jose Manuel Alvarez, & Antonio Lopez. (2009). Model-based road detection using shadowless features and on-line learning.
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Marçal Rusiñol, Lluis Gomez, A. Landman, M. Silva Constenla, & Dimosthenis Karatzas. (2019). Automatic Structured Text Reading for License Plates and Utility Meters. In BMVC Workshop on Visual Artificial Intelligence and Entrepreneurship.
Abstract: Reading text in images has attracted interest from computer vision researchers for
many years. Our technology focuses on the extraction of structured text – such as serial
numbers, machine readings, product codes, etc. – so that it is able to center its attention just on the relevant textual elements. It is conceived to work in an end-to-end fashion, bypassing any explicit text segmentation stage. In this paper we present two different industrial use cases where we have applied our automatic structured text reading technology. In the first one, we demonstrate an outstanding performance when reading license plates compared to the current state of the art. In the second one, we present results on our solution for reading utility meters. The technology is commercialized by a recently created spin-off company, and both solutions are at different stages of integration with final clients.
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Fadi Dornaika, & Angel Sappa. (2007). SFM for Planar Scenes: a Direct and Robust Approach. In book chapter: Informatics in Control, Automation and Robotics II, Ed. J. Filipe, J. Ferrier, J. Cetto and M. Carvalho, pp. 129–136. (best papers ICINCO 2005).
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David Roche, Debora Gil, & Jesus Giraldo. (2013). Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models. BJP - British Journal of Pharmacology, 169(6), 1189–202.
Abstract: Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.
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Jaume Amores, N. Sebe, & Petia Radeva. (2007). Class-Specific Binaryy Correlograms for Object Recognition. In British Machine Vision Conference.
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