Abstract: The broad access to digital cameras, personal computers and Internet, has lead to the generation of large volumes of data in digital form. If we want an effective usage of this huge amount of data, we need automatic tools to allow the retrieval of relevant information. Image data is a particular type of information that requires specific techniques of description and indexing. The computer vision field that studies these kind of techniques is called Content-Based Image Retrieval (CBIR). Instead of using text-based descriptions, a system of CBIR deals on properties that are inherent in the images themselves. Hence, the feature-based description provides a universal via of image expression in contrast with the more than 6000 languages spoken in the world.
Nowadays, the CBIR is a dynamic focus of research that has derived in important applications for many professional groups. The potential fields of application can be such diverse as: the medical domain, the crime prevention, the protection of the intel- lectual property, the journalism, the graphic design, the web search, the preservation of cultural heritage, etc.
The definition on the role of the user is a key point in the development of a CBIR application. The user is in charge to formulate the queries from which the images are retrieved. We have centered our attention on the image retrieval techniques that use queries based on pictorial information. We have identified a taxonomy composed by four main query paradigms: query-by-selection, query-by-iconic-composition, query- by-sketch and query-by-paint. Each one of these paradigms allows a different degree of user expressivity. From a simple image selection, to a complete painting of the query, the user takes control of the input in the CBIR system.
Along the chapters of this thesis we have analyzed the influence that each query paradigm imposes in the internal operations of a CBIR system. Moreover, we have proposed a set of contributions that we have exemplified in the context of a final application.

Abstract: Bag-of-words model (BOW) is inspired by the text classification problem, where a document is represented by an unsorted set of contained words. Analogously, in the object categorization problem, an image is represented by an unsorted set of discrete visual words (BOVW). In these models, relations among visual words are performed after dictionary construction. However, close object regions can have far descriptions in the feature space, being grouped as different visual words. In this paper, we present a method for considering geometrical information of visual words in the dictionary construction step. Object interest regions are obtained by means of the Harris-Affine detector and then described using the SIFT descriptor. Afterward, a contextual-space and a feature-space are defined, and a merging process is used to fuse feature words based on their proximity in the contextual-space. Moreover, we use the Error Correcting Output Codes framework to learn the new dictionary in order to perform multi-class classification. Results show significant classification improvements when spatial information is taken into account in the dictionary construction step.

Abstract: Dominance is referred to the level of influence a person has in a conversation. Dominance is an important research area in social psychology, but the problem of its automatic estimation is a very recent topic in the contexts of social and wearable computing. In this paper, we focus on dominance detection from visual cues. We estimate the correlation among observers by categorizing the dominant people in a set of face-to-face conversations. Different dominance indicators from gestural communication are defined, manually annotated, and compared to the observers opinion. Moreover, the considered indicators are automatically extracted from video sequences and learnt by using binary classifiers. Results from the three analysis shows a high correlation and allows the categorization of dominant people in public discussion video sequences.

Abstract: Cardiovascular Diseases, specially those affecting the Left Ventricle (LV), are the leading cause of death in developed countries with approximately a 30% of all global deaths. In order to address this public health concern, physicians focus on diagnosis and therapy planning. On one hand, early and accurate detection of Regional Wall Motion Abnormalities (RWMA) significantly contributes to a quick diagnosis and prevents the patient to reach more severe stages. On the other hand, a thouroughly knowledge of the normal gross anatomy of the LV, as well as, the distribution of its muscular fibers is crucial for designing specific interventions and therapies (such as pacemaker implanction). Statistical models obtained from the analysis of different imaging modalities allow the computation of the normal ranges of variation within a given population. Normality models are a valuable tool for the definition of objective criterions quantifying the degree of (anomalous) deviation of the LV function and anatomy for a given subject. The creation of statistical models involve addressing three main issues: extraction of data from images, definition of a common domain for comparison of data across patients and designing appropriate statistical analysis schemes. In this PhD thesis we present generic image processing tools for the creation of statistical models of the LV anatomy and function. On one hand, we use differential geometry concepts to define a computational framework (the Normalized Parametric Domain, NPD) suitable for the comparison and fusion of several clinical scores obtained over the LV. On the other hand, we present a variational approach (the Harmonic Phase Flow, HPF) for the estimation of myocardial motion that provides dense and continuous vector fields without overestimating motion at injured areas. These tools are used for the creation of statistical models. Regarding anatomy, we obtain an atlas jointly modelling, both, LV gross anatomy and fiber architecture. Regarding function, we compute normality patterns of scores characterizing the (global and local) LV function and explore, for the first time, the configuration of local scores better suited for RWMA detection.

Abstract: Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images.

Abstract: Cardiovascular diseases are a leading cause of death in developed countries. Most of them are caused by arterial (specially coronary) diseases, mainly caused by plaque accumulation. Such pathology narrows blood flow (stenosis) and affects artery bio- mechanical elastic properties (atherosclerosis). In the last decades, IntraVascular UltraSound (IVUS) has become a usual imaging technique for the diagnosis and follow up of arterial diseases. IVUS is a catheter-based imaging technique which shows a sequence of cross sections of the artery under study. Inspection of a single image gives information about the percentage of stenosis. Meanwhile, inspection of longitudinal views provides information about artery bio-mechanical properties, which can prevent a fatal outcome of the cardiovascular disease. On one hand, dynamics of arteries (due to heart pumping among others) is a major artifact for exploring tissue bio-mechanical properties. On the other one, manual stenosis measurements require a manual tracing of vessel borders, which is a time-consuming task and might suffer from inter-observer variations. This PhD thesis proposes several image processing tools for exploring vessel dy- namics and structures. We present a physics-based model to extract, analyze and correct vessel in-plane rigid dynamics and to retrieve cardiac phase. Furthermore, we introduce a deterministic-statistical method for automatic vessel borders detection. In particular, we address adventitia layer segmentation. An accurate validation pro- tocol to ensure reliable clinical applicability of the methods is a crucial step in any proposal of an algorithm. In this thesis we take special care in designing a valida- tion protocol for each approach proposed and we contribute to the in vivo dynamics validation with a quantitative and objective score to measure the amount of motion suppressed.