Abstract: The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.

Abstract: Color names are required in real-world applications such as image retrieval and image annotation. Traditionally, they are learned from a collection of labelled color chips. These color chips are labelled with color names within a well-defined experimental setup by human test subjects. However naming colors in real-world images differs significantly from this experimental setting. In this paper, we investigate how color names learned from color chips compare to color names learned from real-world images. To avoid hand labelling real-world images with color names we use Google Image to collect a data set. Due to limitations of Google Image this data set contains a substantial quantity of wrongly labelled data. We propose several variants of the PLSA model to learn color names from this noisy data. Experimental results show that color names learned from real-world images significantly outperform color names learned from labelled color chips for both image retrieval and image annotation.

Abstract: Accurate detection of in-vivo vulnerable plaque in coronary arteries is still an open problem. Recent studies show that it is highly related to tissue structure and composition. Intravascular Ultrasound (IVUS) is a powerful imaging technique that gives a detailed cross-sectional image of the vessel, allowing to explore arteries morphology. IVUS data validation is usually performed by comparing post-mortem (in-vitro) IVUS data and corresponding histological analysis of the tissue. The main drawback of this method is the few number of available case studies and validated data due to the complex procedure of histological analysis of the tissue. On the other hand, IVUS data from in-vivo cases is easy to obtain but it can not be histologically validated. In this work, we propose to enhance the in-vitro training data set by selectively including examples from in-vivo plaques. For this purpose, a Sequential Floating Forward Selection method is reformulated in the context of plaque characterization. The enhanced classifier performance is validated on in-vitro data set, yielding an overall accuracy of 91.59% in discriminating among fibrotic, lipidic and calcified plaques, while reducing the gap between in-vivo and in-vitro data analysis. Experimental results suggest that the obtained classifier could be properly applied on in-vivo plaque characterization and also demonstrate that the common hypothesis of assuming the difference between in-vivo and in-vitro as negligible is incorrect.

Abstract: Advanced driver assistance systems (ADASs), and particularly pedestrian protection systems (PPSs), have become an active research area aimed at improving traffic safety. The major challenge of PPSs is the development of reliable on-board pedestrian detection systems. Due to the varying appearance of pedestrians (e.g., different clothes, changing size, aspect ratio, and dynamic shape) and the unstructured environment, it is very difficult to cope with the demanded robustness of this kind of system. Two problems arising in this research area are the lack of public benchmarks and the difficulty in reproducing many of the proposed methods, which makes it difficult to compare the approaches. As a result, surveying the literature by enumerating the proposals one-after-another is not the most useful way to provide a comparative point of view. Accordingly, we present a more convenient strategy to survey the different approaches. We divide the problem of detecting pedestrians from images into different processing steps, each with attached responsibilities. Then, the different proposed methods are analyzed and classified with respect to each processing stage, favoring a comparative viewpoint. Finally, discussion of the important topics is presented, putting special emphasis on the future needs and challenges.

Abstract: In this work, we address the problem of aligning two video sequences. Such alignment refers to synchronization, i.e., the establishment of temporal correspondence between frames of the first and second video, followed by spatial registration of all the temporally corresponding frames. Video synchronization and alignment have been attempted before, but most often in the relatively simple cases of fixed or rigidly attached cameras and simultaneous acquisition. In addition, restrictive assumptions have been applied, including linear time correspondence or the knowledge of the complete trajectories of corresponding scene points; to some extent, these assumptions limit the practical applicability of any solutions developed. We intend to solve the more general problem of aligning video sequences recorded by independently moving cameras that follow similar trajectories, based only on the fusion of image intensity and GPS information. The novelty of our approach is to pose the synchronization as a MAP inference problem on a Bayesian network including the observations from these two sensor types, which have been proved complementary. Alignment results are presented in the context of videos recorded from vehicles driving along the same track at different times, for different road types. In addition, we explore two applications of the proposed video alignment method, both based on change detection between aligned videos. One is the detection of vehicles, which could be of use in ADAS. The other is online difference spotting videos of surveillance rounds.

Abstract: The median graph has been shown to be a good choice to obtain a represen- tative of a set of graphs. However, its computation is a complex problem. Recently, graph embedding into vector spaces has been proposed to obtain approximations of the median graph. The problem with such an approach is how to go from a point in the vector space back to a graph in the graph space. The main contribution of this paper is the generalization of this previ- ous method, proposing a generic recursive procedure that permits to recover the graph corresponding to a point in the vector space, introducing only the amount of approximation inherent to the use of graph matching algorithms. In order to evaluate the proposed method, we compare it with the set me- dian and with the other state-of-the-art embedding-based methods for the median graph computation. The experiments are carried out using four dif- ferent databases (one semi-artificial and three containing real-world data). Results show that with the proposed approach we can obtain better medi- ans, in terms of the sum of distances to the training graphs, than with the previous existing methods.

Abstract: IF JCR 1.455 2010 25/99
In volume visualization, the definition of the regions of interest is inherently an iterative trial-and-error process finding out the best parameters to classify and render the final image. Generally, the user requires a lot of expertise to analyze and edit these parameters through multi-dimensional transfer functions. In this paper, we present a framework of intelligent methods to label on-demand multiple regions of interest. These methods can be split into a two-level GPU-based labelling algorithm that computes in time of rendering a set of labelled structures using the Machine Learning Error-Correcting Output Codes (ECOC) framework. In a pre-processing step, ECOC trains a set of Adaboost binary classifiers from a reduced pre-labelled data set. Then, at the testing stage, each classifier is independently applied on the features of a set of unlabelled samples and combined to perform multi-class labelling. We also propose an alternative representation of these classifiers that allows to highly parallelize the testing stage. To exploit that parallelism we implemented the testing stage in GPU-OpenCL. The empirical results on different data sets for several volume structures shows high computational performance and classification accuracy.