Abstract: Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.

Abstract: 5Y Impact Factor: 1.14 / 3rd (Computer Science, Artificial Intelligence)
We introduce a model of attentional eye guidance based on the rationale that the deployment of gaze is to be considered in the context of a general action-perception loop relying on two strictly intertwined processes: sensory processing, depending on current gaze position, identifies sources of information that are most valuable under the given task; motor processing links such information with the oculomotor act by sampling the next gaze position and thus performing the gaze shift. In such a framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the payoff of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects. The different levels of the action-perception loop are represented in probabilistic form and eventually give rise to a stochastic process that generates the gaze sequence. This way the model also accounts for statistical properties of gaze shifts such as individual scan path variability. Results of the simulations are compared either with experimental data derived from publicly available datasets and from our own experiments.

Abstract: Human Pose Recovery has been studied in the field of Computer Vision for the last 40 years. Several approaches have been reported, and significant improvements have been obtained in both data representation and model design. However, the problem of Human Pose Recovery in uncontrolled environments is far from being solved. In this paper, we define a general taxonomy to group model based approaches for Human Pose Recovery, which is composed of five main modules: appearance, viewpoint, spatial relations, temporal consistence, and behavior. Subsequently, a methodological comparison is performed following the proposed taxonomy, evaluating current SoA approaches in the aforementioned five group categories. As a result of this comparison, we discuss the main advantages and drawbacks of the reviewed literature.

Abstract: Detecting the free road surface ahead of a moving vehicle is an important research topic in different areas of computer vision, such as autonomous driving or car collision warning.
Current vision-based road detection methods are usually based solely on low-level features. Furthermore, they generally assume structured roads, road homogeneity, and uniform lighting conditions, constraining their applicability in real-world scenarios. In this paper, road priors and contextual information are introduced for road detection. First, we propose an algorithm to estimate road priors online using geographical information, providing relevant initial information about the road location. Then, contextual cues, including horizon lines, vanishing points, lane markings, 3-D scene layout, and road geometry, are used in addition to low-level cues derived from the appearance of roads. Finally, a generative model is used to combine these cues and priors, leading to a road detection method that is, to a large degree, robust to varying imaging conditions, road types, and scenarios.

Abstract: In this study, the authors propose the spatial codification of label predictions within the multi-scale stacked sequential learning (MSSL) framework, a successful learning scheme to deal with non-independent identically distributed data entries. After providing a motivation for this objective, they describe its theoretical framework based on the introduction of the blurred shape model as a smart descriptor to codify the spatial distribution of the predicted labels and define the new extended feature set for the second stacked classifier. They then particularise this scheme to be applied in volume segmentation applications. Finally, they test the implementation of the proposed framework in two medical volume segmentation datasets, obtaining significant performance improvements (with a 95% of confidence) in comparison to standard Adaboost classifier and classical MSSL approaches.

Abstract: Change detection is the most important task for video surveillance analytics such as foreground and anomaly detection. Current foreground detectors learn models from annotated images since the goal is to generate a robust foreground model able to detect changes in all possible scenarios. Unfortunately, manual labelling is very expensive. Most advanced supervised learning techniques based on generic object detection datasets currently exhibit very poor performance when applied to surveillance datasets because of the unconstrained nature of such environments in terms of types and appearances of objects. In this paper, we take advantage of change detection for training multiple foreground detectors in an unsupervised manner. We use statistical learning techniques which exploit the use of latent parameters for selecting the best foreground model parameters for a given scenario. In essence, the main novelty of our proposed approach is to combine the where (motion segmentation) and what (learning procedure) in change detection in an unsupervised way for improving the specificity and generalization power of foreground detectors at the same time. We propose a framework based on latent support vector machines that, given a noisy initialization based on motion cues, learns the correct position, aspect ratio, and appearance of all moving objects in a particular scene. Specificity is achieved by learning the particular change detections of a given scenario, and generalization is guaranteed since our method can be applied to any possible scene and foreground object, as demonstrated in the experimental results outperforming the state-of-the-art.

Abstract: Arterial pulse wave velocity (PWV), an independent predictor of cardiovascular disease, physiologically increases with age; however, growing evidence suggests metabolic syndrome (MetS) accelerates this increase. Magnetic resonance imaging (MRI) enables reliable noninvasive assessment of arterial stiffness by measuring arterial PWV in specific vascular segments. We investigated the association between the presence of MetS and its components with carotid PWV (cPWV) in asymptomatic subjects without diabetes. We assessed cPWV by MRI in 61 individuals (mean age, 55.3 ± 14.1 years; median age, 55 years): 30 with MetS and 31 controls with similar age, sex, body mass index, and LDL-cholesterol levels. The study population was dichotomized by the median age. To remove the physiological association between PWV and age, unpaired t tests and multiple regression analyses were performed using the residuals of the regression between PWV and age. cPWV was higher in middle-aged subjects with MetS than in those without (p = 0.001), but no differences were found in elder subjects (p = 0.313). cPWV was associated with diastolic blood pressure (r = 0.276, p = 0.033) and waist circumference (r = 0.268, p = 0.038). The presence of MetS was associated with increased cPWV regardless of age, sex, blood pressure, and waist (p = 0.007). The MetS components contributing independently to an increased cPWV were hypertension (p = 0.018) and hypertriglyceridemia (p = 0.002). The presence of MetS is associated with an increased cPWV in middle-aged subjects. In particular, hypertension and hypertriglyceridemia may contribute to early progression of carotid stiffness.