Abstract: It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.

Abstract: Image segmentations aims to partition an image into a set of non-overlapped regions, called segments. Despite the simplicity of the definition, image segmentation raises as a very complex problem in all its stages. The definition of segment is still unclear. When asking to a human to perform a segmentation, this person segments at different levels of abstraction. Some segments might be a single, well-defined texture whereas some others correspond with an object in the scene which might including multiple textures and colors. For this reason, segmentation is divided in bottom-up segmentation and top-down segmentation. Bottom up-segmentation is problem independent, that is, focused on general properties of the images such as textures or illumination. Top-down segmentation is a problem-dependent approach which looks for specific entities in the scene, such as known objects. This work is focused on bottom-up segmentation. Beginning from the analysis of the lacks of current methods, we propose an approach called RAD. Our approach overcomes the main shortcomings of those methods which use the physics of the light to perform the segmentation. RAD is a topological approach which describes a single-material reflectance. Afterwards, we cope with one of the main problems in image segmentation: non supervised adaptability to image content. To yield a non-supervised method, we use a model of saliency yet presented in this thesis. It computes the saliency of the chromatic transitions of an image by means of a statistical analysis of the images derivatives. This method of saliency is used to build our final approach of segmentation: spRAD. This method is a non-supervised segmentation approach. Our saliency approach has been validated with a psychophysical experiment as well as computationally, overcoming a state-of-the-art saliency method. spRAD also outperforms state-of-the-art segmentation techniques as results obtained with a widely-used segmentation dataset show

Abstract: Wireless endoscopy is a very recent and at the same time unique technique allowing to visualize and study the occurrence of con- tractions and to analyze the intestine motility. Feature extraction is es- sential for getting efficient patterns to detect contractions in wireless video endoscopy of small intestine. We propose a novel method based on anisotropic image filtering and efficient statistical classification of con- traction features. In particular, we apply the image gradient tensor for mining informative skeletons from the original image and a sequence of descriptors for capturing the characteristic pattern of contractions. Fea- tures extracted from the endoluminal images were evaluated in terms of their discriminatory ability in correct classifying images as either belong- ing to contractions or not. Classification was performed by means of a support vector machine classifier with a radial basis function kernel. Our classification rates gave sensitivity of the order of 90.84% and specificity of the order of 94.43% respectively. These preliminary results highlight the high efficiency of the selected descriptors and support the feasibility of the proposed method in assisting the automatic detection and analysis of contractions.

Abstract: In this thesis we tackle the problem of automatic characterization of human coronary vessel in Intravascular Ultrasound (IVUS) image modality. The basis for the whole characterization process is machine learning applied to multi-class problems. In all the presented approaches, the Error-Correcting Output Codes (ECOC) framework is used as central element for the design of multi-class classifiers.
Two main topics are tackled in this thesis. First, the automatic detection of the vessel borders is presented. For this purpose, a novel context-aware classifier for multi-class classification of the vessel morphology is presented, namely ECOC-DRF. Based on ECOC-DRF, the lumen border and the media-adventitia border in IVUS are robustly detected by means of a novel holistic approach, achieving an error comparable with inter-observer variability and with state of the art methods.
The two vessel borders define the atheroma area of the vessel. In this area, tissue characterization is required. For this purpose, we present a framework for automatic plaque characterization by processing both texture in IVUS images and spectral information in raw Radio Frequency data. Furthermore, a novel method for fusing in-vivo and in-vitro IVUS data for plaque characterization is presented, namely pSFFS. The method demonstrates to effectively fuse data generating a classifier that improves the tissue characterization in both in-vitro and in-vivo datasets.
A novel method for automatic video summarization in IVUS sequences is also presented. The method aims to detect the key frames of the sequence, i.e., the frames representative of morphological changes. This novel method represents the basis for video summarization in IVUS as well as the markers for the partition of the vessel into morphological and clinically interesting events.
Finally, multi-class learning based on ECOC is applied to lung tissue characterization in Computed Tomography. The novel proposed approach, based on supervised and unsupervised learning, achieves accurate tissue classification on a large and heterogeneous dataset.