Abstract: Intestinal motility assessment with video capsule endoscopy arises as a novel and challenging clinical fieldwork. This technique is based on the analysis of the patterns of intestinal contractions obtained by labelling all the motility events present in a video provided by a capsule with a wireless micro-camera, which is ingested by the patient. However, the visual analysis of these video sequences presents several im- portant drawbacks, mainly related to both the large amount of time needed for the visualization process, and the low prevalence of intestinal contractions in video.
In this work we propose a machine learning system to automatically detect the intestinal contractions in video capsule endoscopy, driving a very useful but not fea- sible clinical routine into a feasible clinical procedure. Our proposal is divided into two different parts: The first part tackles the problem of the automatic detection of phasic contractions in capsule endoscopy videos. Phasic contractions are dynamic events spanning about 4-5 seconds, which show visual patterns with a high variability. Our proposal is based on a sequential design which involves the analysis of textural, color and blob features with powerful classifiers such as SVM. This approach appears to cope with two basic aims: the reduction of the imbalance rate of the data set, and the modular construction of the system, which adds the capability of including domain knowledge as new stages in the cascade. The second part of the current work tackles the problem of the automatic detection of tonic contractions. Tonic contrac- tions manifest in capsule endoscopy as a sustained pattern of the folds and wrinkles of the intestine, which may be prolonged for an undetermined span of time. Our proposal is based on the analysis of the wrinkle patterns, presenting a comparative study of diverse features and classification methods, and providing a set of appro- priate descriptors for their characterization. We provide a detailed analysis of the performance achieved by our system both in a qualitative and a quantitative way.

Abstract: Wireless Capsule Endoscopy (WCE) is a technique for inner-visualization of the entire small intestine and, thus, offers an interesting perspective on intestinal motility. The two major drawbacks of this technique are: 1) huge amount of data acquired by WCE makes the motility analysis tedious and 2) since the capsule is the first tool that offers complete inner-visualization of the small intestine,the exact importance of the observed events is still an open issue. Therefore, in this thesis, a novel computer-aided system for intestinal motility analysis is presented. The goal of the system is to provide an easily-comprehensible visual description of motility-related intestinal events to a physician. In order to do so, several tools based either on computer vision concepts or on machine learning techniques are presented. A method for transforming 3D video signal to a holistic image of intestinal motility, called motility bar, is proposed. The method calculates the optimal mapping from video into image from the intestinal motility point of view.
To characterize intestinal motility, methods for automatic extraction of motility information from WCE are presented. Two of them are based on the motility bar and two of them are based on frame-per-frame analysis. In particular, four algorithms dealing with the problems of intestinal contraction detection, lumen size estimation, intestinal content characterization and wrinkle frame detection are proposed and validated. The results of the algorithms are converted into sequential features using an online statistical test. This test is designed to work with multivariate data streams. To this end, we propose a novel formulation of concentration inequality that is introduced into a robust adaptive windowing algorithm for multivariate data streams. The algorithm is used to obtain robust representation of segments with constant intestinal motility activity. The obtained sequential features are shown to be discriminative in the problem of abnormal motility characterization.
Finally, we tackle the problem of efficient labeling. To this end, we incorporate active learning concepts to the problems present in WCE data and propose two approaches. The first one is based the concepts of sequential learning and the second one adapts the partition-based active learning to an error-free labeling scheme. All these steps are sufficient to provide an extensive visual description of intestinal motility that can be used by an expert as decision support system.

Abstract: In this thesis we tackle the problem of automatic characterization of human coronary vessel in Intravascular Ultrasound (IVUS) image modality. The basis for the whole characterization process is machine learning applied to multi-class problems. In all the presented approaches, the Error-Correcting Output Codes (ECOC) framework is used as central element for the design of multi-class classifiers.
Two main topics are tackled in this thesis. First, the automatic detection of the vessel borders is presented. For this purpose, a novel context-aware classifier for multi-class classification of the vessel morphology is presented, namely ECOC-DRF. Based on ECOC-DRF, the lumen border and the media-adventitia border in IVUS are robustly detected by means of a novel holistic approach, achieving an error comparable with inter-observer variability and with state of the art methods.
The two vessel borders define the atheroma area of the vessel. In this area, tissue characterization is required. For this purpose, we present a framework for automatic plaque characterization by processing both texture in IVUS images and spectral information in raw Radio Frequency data. Furthermore, a novel method for fusing in-vivo and in-vitro IVUS data for plaque characterization is presented, namely pSFFS. The method demonstrates to effectively fuse data generating a classifier that improves the tissue characterization in both in-vitro and in-vivo datasets.
A novel method for automatic video summarization in IVUS sequences is also presented. The method aims to detect the key frames of the sequence, i.e., the frames representative of morphological changes. This novel method represents the basis for video summarization in IVUS as well as the markers for the partition of the vessel into morphological and clinically interesting events.
Finally, multi-class learning based on ECOC is applied to lung tissue characterization in Computed Tomography. The novel proposed approach, based on supervised and unsupervised learning, achieves accurate tissue classification on a large and heterogeneous dataset.

Abstract: Sequential learning is that discipline of machine learning that deals with dependent data. In this paper, we use the Multi-scale Stacked Sequential Learning approach (MSSL) to solve the task of pixel-wise classification based on contextual information. The main contribution of this work is a shifting technique applied during the testing phase that makes possible, thanks to template images, to classify objects at different sizes. The results show that the proposed method robustly classifies such objects capturing their spatial relationships.

Abstract: We describe an equivalence of categories between the category of mixed Hodge structures and a category of equivariant vector bundles on a toric model of the complex projective plane which verify some semistability condition. We then apply this correspondence to define an invariant which generalizes the notion of R-split mixed Hodge structure and give calculations for the first group of cohomology of possibly non smooth or non-complete curves of genus 0 and 1. Finally, we describe some extension groups of mixed Hodge structures in terms of equivariant extensions of coherent sheaves. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim