Abstract: It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1

Abstract: Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice.

Abstract: In this thesis we tackle the problem of automatic characterization of human coronary vessel in Intravascular Ultrasound (IVUS) image modality. The basis for the whole characterization process is machine learning applied to multi-class problems. In all the presented approaches, the Error-Correcting Output Codes (ECOC) framework is used as central element for the design of multi-class classifiers.
Two main topics are tackled in this thesis. First, the automatic detection of the vessel borders is presented. For this purpose, a novel context-aware classifier for multi-class classification of the vessel morphology is presented, namely ECOC-DRF. Based on ECOC-DRF, the lumen border and the media-adventitia border in IVUS are robustly detected by means of a novel holistic approach, achieving an error comparable with inter-observer variability and with state of the art methods.
The two vessel borders define the atheroma area of the vessel. In this area, tissue characterization is required. For this purpose, we present a framework for automatic plaque characterization by processing both texture in IVUS images and spectral information in raw Radio Frequency data. Furthermore, a novel method for fusing in-vivo and in-vitro IVUS data for plaque characterization is presented, namely pSFFS. The method demonstrates to effectively fuse data generating a classifier that improves the tissue characterization in both in-vitro and in-vivo datasets.
A novel method for automatic video summarization in IVUS sequences is also presented. The method aims to detect the key frames of the sequence, i.e., the frames representative of morphological changes. This novel method represents the basis for video summarization in IVUS as well as the markers for the partition of the vessel into morphological and clinically interesting events.
Finally, multi-class learning based on ECOC is applied to lung tissue characterization in Computed Tomography. The novel proposed approach, based on supervised and unsupervised learning, achieves accurate tissue classification on a large and heterogeneous dataset.

Abstract: In this paper we evaluate the use of Relative Location Features (RLF) on a historical document segmentation task, and compare the quality of the results obtained on structured and unstructured documents using RLF and not using them. We prove that using these features improve the final segmentation on documents with a strong structure, while their application on unstructured documents does not show significant improvement. Although this paper is not focused on segmenting unstructured documents, results obtained on a benchmark dataset are equal or even overcome previous results of similar works.

Abstract: There are many works in color that assume illumination change can be modeled by multiplying sensor responses by individual scaling factors. The early research in this area is sometimes grouped under the heading “von Kries adaptation”: the scaling factors are applied to the cone responses. In more recent studies, both in psychophysics and in computational analysis, it has been proposed that scaling factors should be applied to linear combinations of the cones that have narrower support: they should be applied to the so-called “sharp sensors.” In this paper, we generalize the computational approach to spectral sharpening in three important ways. First, we introduce spherical sampling as a tool that allows us to enumerate in a principled way all linear combinations of the cones. This allows us to, second, find the optimal sharp sensors that minimize a variety of error measures including CIE Delta E (previous work on spectral sharpening minimized RMS) and color ratio stability. Lastly, we extend the spherical sampling paradigm to the multispectral case. Here the objective is to model the interaction of light and surface in terms of color signal spectra. Spherical sampling is shown to improve on the state of the art.

Abstract: Smiling is an indispensable element of nonverbal social interaction. Besides, automatic distinction between spontaneous and posed expressions is important for visual analysis of social signals. Therefore, in this paper, we propose a method to distinguish between spontaneous and posed enjoyment smiles by using the dynamics of eyelid, cheek, and lip corner movements. The discriminative power of these movements, and the effect of different fusion levels are investigated on multiple databases. Our results improve the state-of-the-art. We also introduce the largest spontaneous/posed enjoyment smile database collected to date, and report new empirical and conceptual findings on smile dynamics. The collected database consists of 1240 samples of 400 subjects. Moreover, it has the unique property of having an age range from 8 to 76 years. Large scale experiments on the new database indicate that eyelid dynamics are highly relevant for smile classification, and there are age-related differences in smile dynamics.