Abstract: ChaLearn is organizing the Automatic Machine Learning (AutoML) contest 2015, which challenges participants to solve classication and regression problems without any human intervention. Participants' code is automatically run on the contest servers to train and test learning machines. However, there is no obligation to submit code; half of the prizes can be won by submitting prediction results only. Datasets of progressively increasing diculty are introduced throughout the six rounds of the challenge. (Participants can
enter the competition in any round.) The rounds alternate phases in which learners are tested on datasets participants have not seen (AutoML), and phases in which participants have limited time to tweak their algorithms on those datasets to improve performance (Tweakathon). This challenge will push the state of the art in fully automatic machine learning on a wide range of real-world problems. The platform will remain available beyond the termination of the challenge: http://codalab.org/AutoML.

Abstract: Changes in cardiac deformation patterns are correlated with cardiac pathologies. Deformation can be extracted from tagging Magnetic Resonance Imaging (tMRI) using Optical Flow (OF) techniques. For applications of OF in a clinical setting it is important to assess to what extent the performance of a particular OF method is stable across dierent clinical acquisition artifacts. This paper presents a statistical validation framework, based on ANOVA, to assess the motion and appearance factors that have the largest in uence on OF accuracy drop.
In order to validate this framework, we created a database of simulated tMRI data including the most common artifacts of MRI and test three dierent OF methods, including HARP.

Abstract: Characterization of carotid plaque composition, more specifically the amount of lipid core, fibrous tissue, and calcified tissue, is an important task for the identification of plaques that are prone to rupture, and thus for early risk estimation of cardiovascular and cerebrovascular events. Due to its low costs and wide availability, carotid ultrasound has the potential to become the modality of choice for plaque characterization in clinical practice. However, its significant image noise, coupled with the small size of the plaques and their complex appearance, makes it difficult for automated techniques to discriminate between the different plaque constituents. In this paper, we propose to address this challenging problem by exploiting the unique capabilities of the emerging deep learning framework. More specifically, and unlike existing works which require a priori definition of specific imaging features or thresholding values, we propose to build a convolutional neural network (CNN) that will automatically extract from the images the information that is optimal for the identification of the different plaque constituents. We used approximately 90 000 patches extracted from a database of images and corresponding expert plaque characterizations to train and to validate the proposed CNN. The results of cross-validation experiments show a correlation of about 0.90 with the clinical assessment for the estimation of lipid core, fibrous cap, and calcified tissue areas, indicating the potential of deep learning for the challenging task of automatic characterization of plaque composition in carotid ultrasound.

Abstract: Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.

Abstract: Class incremental semantic segmentation (CISS) focuses on alleviating catastrophic forgetting to improve discrimination. Previous work mainly exploit regularization (e.g., knowledge distillation) to maintain previous knowledge in the current model. However, distillation alone often yields limited gain to the model since only the representations of old and new models are restricted to be consistent. In this paper, we propose a simple yet effective method to obtain a model with strong memory of old knowledge, named Endpoints Weight Fusion (EWF). In our method, the model containing old knowledge is fused with the model retaining new knowledge in a dynamic fusion manner, strengthening the memory of old classes in ever-changing distributions. In addition, we analyze the relation between our fusion strategy and a popular moving average technique EMA, which reveals why our method is more suitable for class-incremental learning. To facilitate parameter fusion with closer distance in the parameter space, we use distillation to enhance the optimization process. Furthermore, we conduct experiments on two widely used datasets, achieving the state-of-the-art performance.

Abstract: Class-specific text proposal algorithms can efficiently reduce the search space for possible text object locations in an image. In this paper we combine the Text Proposals algorithm with Fully Convolutional Networks to efficiently reduce the number of proposals while maintaining the same recall level and thus gaining a significant speed up. Our experiments demonstrate that such text proposal approaches yield significantly higher recall rates than state-of-the-art text localization techniques, while also producing better-quality localizations. Our results on the ICDAR 2015 Robust Reading Competition (Challenge 4) and the COCO-text datasets show that, when combined with strong word classifiers, this recall margin leads to state-of-the-art results in end-to-end scene text recognition.

Abstract: Clinical studies on atherosclerosis regression/progression performed by intravascular ultrasound analysis would benefit from accurate alignment of sequences of the same patient before and after clinical interventions and at follow-up. In this article, a methodology for automatic alignment of intravascular ultrasound sequences based on the dynamic time warping technique is proposed. The non-rigid alignment is adapted to the specific task by applying it to multidimensional signals describing the morphologic content of the vessel. Moreover, dynamic time warping is embedded into a framework comprising a strategy to address partial overlapping between acquisitions and a term that regularizes non-physiologic temporal compression/expansion of the sequences. Extensive validation is performed on both synthetic and in vivo data. The proposed method reaches alignment errors of approximately 0.43 mm for pairs of sequences acquired during the same intervention phase and 0.77 mm for pairs of sequences acquired at successive intervention stages.