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Mireia Sole, Joan Blanco, Debora Gil, G. Fonseka, Richard Frodsham, Oliver Valero, et al. (2017). Análisis 3d de la territorialidad cromosómica en células espermatogénicas: explorando la infertilidad desde un nuevo prisma. ASEBIR - Revista Asociación para el Estudio de la Biología de la Reproducción, 105.
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Katerine Diaz, Aura Hernandez-Sabate, & Antonio Lopez. (2016). A reduced feature set for driver head pose estimation. ASOC - Applied Soft Computing, 45, 98–107.
Abstract: Evaluation of driving performance is of utmost importance in order to reduce road accident rate. Since driving ability includes visual-spatial and operational attention, among others, head pose estimation of the driver is a crucial indicator of driving performance. This paper proposes a new automatic method for coarse and fine head's yaw angle estimation of the driver. We rely on a set of geometric features computed from just three representative facial keypoints, namely the center of the eyes and the nose tip. With these geometric features, our method combines two manifold embedding methods and a linear regression one. In addition, the method has a confidence mechanism to decide if the classification of a sample is not reliable. The approach has been tested using the CMU-PIE dataset and our own driver dataset. Despite the very few facial keypoints required, the results are comparable to the state-of-the-art techniques. The low computational cost of the method and its robustness makes feasible to integrate it in massive consume devices as a real time application.
Keywords: Head pose estimation; driving performance evaluation; subspace based methods; linear regression
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Oriol Ramos Terrades, Albert Berenguel, & Debora Gil. (2022). A Flexible Outlier Detector Based on a Topology Given by Graph Communities. BDR - Big Data Research, 29, 100332.
Abstract: Outlier detection is essential for optimal performance of machine learning methods and statistical predictive models. Their detection is especially determinant in small sample size unbalanced problems, since in such settings outliers become highly influential and significantly bias models. This particular experimental settings are usual in medical applications, like diagnosis of rare pathologies, outcome of experimental personalized treatments or pandemic emergencies. In contrast to population-based methods, neighborhood based local approaches compute an outlier score from the neighbors of each sample, are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. A main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters, like the number of neighbors.
This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world and synthetic data sets show that our approach outperforms, both, local and global strategies in multi and single view settings.
Keywords: Classification algorithms; Detection algorithms; Description of feature space local structure; Graph communities; Machine learning algorithms; Outlier detectors
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Laura Igual, Joan Carles Soliva, Antonio Hernandez, Sergio Escalera, Xavier Jimenez, Oscar Vilarroya, et al. (2011). A fully-automatic caudate nucleus segmentation of brain MRI: Application in volumetric analysis of pediatric attention-deficit/hyperactivity disorder. BEO - BioMedical Engineering Online, 10(105), 1–23.
Abstract: Background
Accurate automatic segmentation of the caudate nucleus in magnetic resonance images (MRI) of the brain is of great interest in the analysis of developmental disorders. Segmentation methods based on a single atlas or on multiple atlases have been shown to suitably localize caudate structure. However, the atlas prior information may not represent the structure of interest correctly. It may therefore be useful to introduce a more flexible technique for accurate segmentations.
Method
We present Cau-dateCut: a new fully-automatic method of segmenting the caudate nucleus in MRI. CaudateCut combines an atlas-based segmentation strategy with the Graph Cut energy-minimization framework. We adapt the Graph Cut model to make it suitable for segmenting small, low-contrast structures, such as the caudate nucleus, by defining new energy function data and boundary potentials. In particular, we exploit information concerning the intensity and geometry, and we add supervised energies based on contextual brain structures. Furthermore, we reinforce boundary detection using a new multi-scale edgeness measure.
Results
We apply the novel CaudateCut method to the segmentation of the caudate nucleus to a new set of 39 pediatric attention-deficit/hyperactivity disorder (ADHD) patients and 40 control children, as well as to a public database of 18 subjects. We evaluate the quality of the segmentation using several volumetric and voxel by voxel measures. Our results show improved performance in terms of segmentation compared to state-of-the-art approaches, obtaining a mean overlap of 80.75%. Moreover, we present a quantitative volumetric analysis of caudate abnormalities in pediatric ADHD, the results of which show strong correlation with expert manual analysis.
Conclusion
CaudateCut generates segmentation results that are comparable to gold-standard segmentations and which are reliable in the analysis of differentiating neuroanatomical abnormalities between healthy controls and pediatric ADHD.
Keywords: Brain caudate nucleus; segmentation; MRI; atlas-based strategy; Graph Cut framework
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Marc Oliu, Ciprian Corneanu, Kamal Nasrollahi, Olegs Nikisins, Sergio Escalera, Yunlian Sun, et al. (2016). Improved RGB-D-T based Face Recognition. BIO - IET Biometrics, 5(4), 297–303.
Abstract: Reliable facial recognition systems are of crucial importance in various applications from entertainment to security. Thanks to the deep-learning concepts introduced in the field, a significant improvement in the performance of the unimodal facial recognition systems has been observed in the recent years. At the same time a multimodal facial recognition is a promising approach. This study combines the latest successes in both directions by applying deep learning convolutional neural networks (CNN) to the multimodal RGB, depth, and thermal (RGB-D-T) based facial recognition problem outperforming previously published results. Furthermore, a late fusion of the CNN-based recognition block with various hand-crafted features (local binary patterns, histograms of oriented gradients, Haar-like rectangular features, histograms of Gabor ordinal measures) is introduced, demonstrating even better recognition performance on a benchmark RGB-D-T database. The obtained results in this study show that the classical engineered features and CNN-based features can complement each other for recognition purposes.
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Ajian Liu, Xuan Li, Jun Wan, Yanyan Liang, Sergio Escalera, Hugo Jair Escalante, et al. (2020). Cross-ethnicity Face Anti-spoofing Recognition Challenge: A Review. BIO - IET Biometrics, 10(1), 24–43.
Abstract: Face anti-spoofing is critical to prevent face recognition systems from a security breach. The biometrics community has %possessed achieved impressive progress recently due the excellent performance of deep neural networks and the availability of large datasets. Although ethnic bias has been verified to severely affect the performance of face recognition systems, it still remains an open research problem in face anti-spoofing. Recently, a multi-ethnic face anti-spoofing dataset, CASIA-SURF CeFA, has been released with the goal of measuring the ethnic bias. It is the largest up to date cross-ethnicity face anti-spoofing dataset covering 3 ethnicities, 3 modalities, 1,607 subjects, 2D plus 3D attack types, and the first dataset including explicit ethnic labels among the recently released datasets for face anti-spoofing. We organized the Chalearn Face Anti-spoofing Attack Detection Challenge which consists of single-modal (e.g., RGB) and multi-modal (e.g., RGB, Depth, Infrared (IR)) tracks around this novel resource to boost research aiming to alleviate the ethnic bias. Both tracks have attracted 340 teams in the development stage, and finally 11 and 8 teams have submitted their codes in the single-modal and multi-modal face anti-spoofing recognition challenges, respectively. All the results were verified and re-ran by the organizing team, and the results were used for the final ranking. This paper presents an overview of the challenge, including its design, evaluation protocol and a summary of results. We analyze the top ranked solutions and draw conclusions derived from the competition. In addition we outline future work directions.
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David Roche, Debora Gil, & Jesus Giraldo. (2013). Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models. BJP - British Journal of Pharmacology, 169(6), 1189–202.
Abstract: Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.
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Manisha Das, Deep Gupta, Petia Radeva, & Ashwini M. Bakde. (2021). Optimized CT-MR neurological image fusion framework using biologically inspired spiking neural model in hybrid ℓ1 - ℓ0 layer decomposition domain. BSPC - Biomedical Signal Processing and Control, 68, 102535.
Abstract: Medical image fusion plays an important role in the clinical diagnosis of several critical neurological diseases by merging complementary information available in multimodal images. In this paper, a novel CT-MR neurological image fusion framework is proposed using an optimized biologically inspired feedforward neural model in two-scale hybrid ℓ1 − ℓ0 decomposition domain using gray wolf optimization to preserve the structural as well as texture information present in source CT and MR images. Initially, the source images are subjected to two-scale ℓ1 − ℓ0 decomposition with optimized parameters, giving a scale-1 detail layer, a scale-2 detail layer and a scale-2 base layer. Two detail layers at scale-1 and 2 are fused using an optimized biologically inspired neural model and weighted average scheme based on local energy and modified spatial frequency to maximize the preservation of edges and local textures, respectively, while the scale-2 base layer gets fused using choose max rule to preserve the background information. To optimize the hyper-parameters of hybrid ℓ1 − ℓ0 decomposition and biologically inspired neural model, a fitness function is evaluated based on spatial frequency and edge index of the resultant fused image obtained by adding all the fused components. The fusion performance is analyzed by conducting extensive experiments on different CT-MR neurological images. Experimental results indicate that the proposed method provides better-fused images and outperforms the other state-of-the-art fusion methods in both visual and quantitative assessments.
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Frederic Sampedro, Sergio Escalera, Anna Domenech, & Ignasi Carrio. (2014). A computational framework for cancer response assessment based on oncological PET-CT scans. CBM - Computers in Biology and Medicine, 55, 92–99.
Abstract: In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks.
Keywords: Computer aided diagnosis; Nuclear medicine; Machine learning; Image processing; Quantitative analysis
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Michal Drozdzal, Santiago Segui, Petia Radeva, Carolina Malagelada, Fernando Azpiroz, & Jordi Vitria. (2015). Motility bar: a new tool for motility analysis of endoluminal videos. CBM - Computers in Biology and Medicine, 65, 320–330.
Abstract: Wireless Capsule Endoscopy (WCE) provides a new perspective of the small intestine, since it enables, for the first time, visualization of the entire organ. However, the long visual video analysis time, due to the large number of data in a single WCE study, was an important factor impeding the widespread use of the capsule as a tool for intestinal abnormalities detection. Therefore, the introduction of WCE triggered a new field for the application of computational methods, and in particular, of computer vision. In this paper, we follow the computational approach and come up with a new perspective on the small intestine motility problem. Our approach consists of three steps: first, we review a tool for the visualization of the motility information contained in WCE video; second, we propose algorithms for the characterization of two motility building-blocks: contraction detector and lumen size estimation; finally, we introduce an approach to detect segments of stable motility behavior. Our claims are supported by an evaluation performed with 10 WCE videos, suggesting that our methods ably capture the intestinal motility information.
Keywords: Small intestine; Motility; WCE; Computer vision; Image classification
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Santiago Segui, Michal Drozdzal, Guillem Pascual, Petia Radeva, Carolina Malagelada, Fernando Azpiroz, et al. (2016). Generic Feature Learning for Wireless Capsule Endoscopy Analysis. CBM - Computers in Biology and Medicine, 79, 163–172.
Abstract: The interpretation and analysis of wireless capsule endoscopy (WCE) recordings is a complex task which requires sophisticated computer aided decision (CAD) systems to help physicians with video screening and, finally, with the diagnosis. Most CAD systems used in capsule endoscopy share a common system design, but use very different image and video representations. As a result, each time a new clinical application of WCE appears, a new CAD system has to be designed from the scratch. This makes the design of new CAD systems very time consuming. Therefore, in this paper we introduce a system for small intestine motility characterization, based on Deep Convolutional Neural Networks, which circumvents the laborious step of designing specific features for individual motility events. Experimental results show the superiority of the learned features over alternative classifiers constructed using state-of-the-art handcrafted features. In particular, it reaches a mean classification accuracy of 96% for six intestinal motility events, outperforming the other classifiers by a large margin (a 14% relative performance increase).
Keywords: Wireless capsule endoscopy; Deep learning; Feature learning; Motility analysis
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Sumit K. Banchhor, Narendra D. Londhe, Tadashi Araki, Luca Saba, Petia Radeva, Narendra N. Khanna, et al. (2018). Calcium detection, its quantification, and grayscale morphology-based risk stratification using machine learning in multimodality big data coronary and carotid scans: A review. CBM - Computers in Biology and Medicine, 101, 184–198.
Abstract: Purpose of review
Atherosclerosis is the leading cause of cardiovascular disease (CVD) and stroke. Typically, atherosclerotic calcium is found during the mature stage of the atherosclerosis disease. It is therefore often a challenge to identify and quantify the calcium. This is due to the presence of multiple components of plaque buildup in the arterial walls. The American College of Cardiology/American Heart Association guidelines point to the importance of calcium in the coronary and carotid arteries and further recommend its quantification for the prevention of heart disease. It is therefore essential to stratify the CVD risk of the patient into low- and high-risk bins.
Recent finding
Calcium formation in the artery walls is multifocal in nature with sizes at the micrometer level. Thus, its detection requires high-resolution imaging. Clinical experience has shown that even though optical coherence tomography offers better resolution, intravascular ultrasound still remains an important imaging modality for coronary wall imaging. For a computer-based analysis system to be complete, it must be scientifically and clinically validated. This study presents a state-of-the-art review (condensation of 152 publications after examining 200 articles) covering the methods for calcium detection and its quantification for coronary and carotid arteries, the pros and cons of these methods, and the risk stratification strategies. The review also presents different kinds of statistical models and gold standard solutions for the evaluation of software systems useful for calcium detection and quantification. Finally, the review concludes with a possible vision for designing the next-generation system for better clinical outcomes.
Keywords: Heart disease; Stroke; Atherosclerosis; Intravascular; Coronary; Carotid; Calcium; Morphology; Risk stratification
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Giuseppe Pezzano, Oliver Diaz, Vicent Ribas Ripoll, & Petia Radeva. (2021). CoLe-CNN+: Context learning – Convolutional neural network for COVID-19-Ground-Glass-Opacities detection and segmentation. CBM - Computers in Biology and Medicine, 136, 104689.
Abstract: The most common tool for population-wide COVID-19 identification is the Reverse Transcription-Polymerase Chain Reaction test that detects the presence of the virus in the throat (or sputum) in swab samples. This test has a sensitivity between 59% and 71%. However, this test does not provide precise information regarding the extension of the pulmonary infection. Moreover, it has been proven that through the reading of a computed tomography (CT) scan, a clinician can provide a more complete perspective of the severity of the disease. Therefore, we propose a comprehensive system for fully-automated COVID-19 detection and lesion segmentation from CT scans, powered by deep learning strategies to support decision-making process for the diagnosis of COVID-19.
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Henry Velesaca, Patricia Suarez, Raul Mira, & Angel Sappa. (2021). Computer Vision based Food Grain Classification: a Comprehensive Survey. CEA - Computers and Electronics in Agriculture, 187, 106287.
Abstract: This manuscript presents a comprehensive survey on recent computer vision based food grain classification techniques. It includes state-of-the-art approaches intended for different grain varieties. The approaches proposed in the literature are analyzed according to the processing stages considered in the classification pipeline, making it easier to identify common techniques and comparisons. Additionally, the type of images considered by each approach (i.e., images from the: visible, infrared, multispectral, hyperspectral bands) together with the strategy used to generate ground truth data (i.e., real and synthetic images) are reviewed. Finally, conclusions highlighting future needs and challenges are presented.
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Eduardo Aguilar, Bhalaji Nagarajan, Beatriz Remeseiro, & Petia Radeva. (2022). Bayesian deep learning for semantic segmentation of food images. CEE - Computers and Electrical Engineering, 103, 108380.
Abstract: Deep learning has provided promising results in various applications; however, algorithms tend to be overconfident in their predictions, even though they may be entirely wrong. Particularly for critical applications, the model should provide answers only when it is very sure of them. This article presents a Bayesian version of two different state-of-the-art semantic segmentation methods to perform multi-class segmentation of foods and estimate the uncertainty about the given predictions. The proposed methods were evaluated on three public pixel-annotated food datasets. As a result, we can conclude that Bayesian methods improve the performance achieved by the baseline architectures and, in addition, provide information to improve decision-making. Furthermore, based on the extracted uncertainty map, we proposed three measures to rank the images according to the degree of noisy annotations they contained. Note that the top 135 images ranked by one of these measures include more than half of the worst-labeled food images.
Keywords: Deep learning; Uncertainty quantification; Bayesian inference; Image segmentation; Food analysis
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