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Frederic Sampedro, Anna Domenech, & Sergio Escalera. (2014). Obtaining quantitative global tumoral state indicators based on whole-body PET/CT scans: A breast cancer case study. NMC - Nuclear Medicine Communications, 35(4), 362–371.
Abstract: Objectives: In this work we address the need for the computation of quantitative global tumoral state indicators from oncological whole-body PET/computed tomography scans. The combination of such indicators with other oncological information such as tumor markers or biopsy results would prove useful in oncological decision-making scenarios.
Materials and methods: From an ordering of 100 breast cancer patients on the basis of oncological state through visual analysis by a consensus of nuclear medicine specialists, a set of numerical indicators computed from image analysis of the PET/computed tomography scan is presented, which attempts to summarize a patient’s oncological state in a quantitative manner taking into consideration the total tumor volume, aggressiveness, and spread.
Results: Results obtained by comparative analysis of the proposed indicators with respect to the experts’ evaluation show up to 87% Pearson’s correlation coefficient when providing expert-guided PET metabolic tumor volume segmentation and 64% correlation when using completely automatic image analysis techniques.
Conclusion: Global quantitative tumor information obtained by whole-body PET/CT image analysis can prove useful in clinical nuclear medicine settings and oncological decision-making scenarios. The completely automatic computation of such indicators would improve its impact as time efficiency and specialist independence would be achieved.
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C. Butakoff, Simone Balocco, F.M. Sukno, C. Hoogendoorn, C. Tobon-Gomez, G. Avegliano, et al. (2016). Left-ventricular Epi- and Endocardium Extraction from 3D Ultrasound Images Using an Automatically Constructed 3D ASM. CMBBE - Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization, 4(5), 265–280.
Abstract: In this paper, we propose an automatic method for constructing an active shape model (ASM) to segment the complete cardiac left ventricle in 3D ultrasound (3DUS) images, which avoids costly manual landmarking. The automatic construction of the ASM has already been addressed in the literature; however, the direct application of these methods to 3DUS is hampered by a high level of noise and artefacts. Therefore, we propose to construct the ASM by fusing the multidetector computed tomography data, to learn the shape, with the artificially generated 3DUS, in order to learn the neighbourhood of the boundaries. Our artificial images were generated by two approaches: a faster one that does not take into account the geometry of the transducer, and a more comprehensive one, implemented in Field II toolbox. The segmentation accuracy of our ASM was evaluated on 20 patients with left-ventricular asynchrony, demonstrating plausibility of the approach.
Keywords: ASM; cardiac segmentation; statistical model; shape model; 3D ultrasound; cardiac segmentation
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Carlo Gatta, & Francesco Ciompi. (2014). Stacked Sequential Scale-Space Taylor Context. TPAMI - IEEE Transactions on Pattern Analysis and Machine Intelligence, 36(8), 1694–1700.
Abstract: We analyze sequential image labeling methods that sample the posterior label field in order to gather contextual information. We propose an effective method that extracts local Taylor coefficients from the posterior at different scales. Results show that our proposal outperforms state-of-the-art methods on MSRC-21, CAMVID, eTRIMS8 and KAIST2 data sets.
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Pedro Martins, Paulo Carvalho, & Carlo Gatta. (2014). Context-aware features and robust image representations. JVCIR - Journal of Visual Communication and Image Representation, 25(2), 339–348.
Abstract: Local image features are often used to efficiently represent image content. The limited number of types of features that a local feature extractor responds to might be insufficient to provide a robust image representation. To overcome this limitation, we propose a context-aware feature extraction formulated under an information theoretic framework. The algorithm does not respond to a specific type of features; the idea is to retrieve complementary features which are relevant within the image context. We empirically validate the method by investigating the repeatability, the completeness, and the complementarity of context-aware features on standard benchmarks. In a comparison with strictly local features, we show that our context-aware features produce more robust image representations. Furthermore, we study the complementarity between strictly local features and context-aware ones to produce an even more robust representation.
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Simeon Petkov, Xavier Carrillo, Petia Radeva, & Carlo Gatta. (2014). Diaphragm border detection in coronary X-ray angiographies: New method and applications. CMIG - Computerized Medical Imaging and Graphics, 38(4), 296–305.
Abstract: X-ray angiography is widely used in cardiac disease diagnosis during or prior to intravascular interventions. The diaphragm motion and the heart beating induce gray-level changes, which are one of the main obstacles in quantitative analysis of myocardial perfusion. In this paper we focus on detecting the diaphragm border in both single images or whole X-ray angiography sequences. We show that the proposed method outperforms state of the art approaches. We extend a previous publicly available data set, adding new ground truth data. We also compose another set of more challenging images, thus having two separate data sets of increasing difficulty. Finally, we show three applications of our method: (1) a strategy to reduce false positives in vessel enhanced images; (2) a digital diaphragm removal algorithm; (3) an improvement in Myocardial Blush Grade semi-automatic estimation.
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