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Francesco Ciompi, Simone Balocco, Juan Rigla, Xavier Carrillo, Josefina Mauri, & Petia Radeva. (2016). Computer-Aided Detection of Intra-Coronary Stent in Intravascular Ultrasound Sequences. MP - Medical Physics, 43(10).
Abstract: Purpose: An intraluminal coronary stent is a metal mesh tube deployed in a stenotic artery during Percutaneous Coronary Intervention (PCI), in order to prevent acute vessel occlusion. The identi cation of struts location and the de nition of the stent shape are relevant for PCI planning 15 and for patient follow-up. We present a fully-automatic framework for Computer-Aided Detection
(CAD) of intra-coronary stents in Intravascular Ultrasound (IVUS) image sequences. The CAD system is able to detect stent struts and estimate the stent shape.
Methods: The proposed CAD uses machine learning to provide a comprehensive interpretation of the local structure of the vessel by means of semantic classi cation. The output of the classi cation 20 stage is then used to detect struts and to estimate the stent shape. The proposed approach is validated using a multi-centric data-set of 1,015 images from 107 IVUS sequences containing both metallic and bio-absorbable stents.
Results: The method was able to detect structs in both metallic stents with an overall F-measure of 77.7% and a mean distance of 0.15 mm from manually annotated struts, and in bio-absorbable 25 stents with an overall F-measure of 77.4% and a mean distance of 0.09 mm from manually annotated struts.
Conclusions: The results are close to the inter-observer variability and suggest that the system has the potential of being used as method for aiding percutaneous interventions.
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Mariella Dimiccoli. (2016). Fundamentals of cone regression. Journal of Statistics Surveys, 53–99.
Abstract: Cone regression is a particular case of quadratic programming that minimizes a weighted sum of squared residuals under a set of linear inequality constraints. Several important statistical problems such as isotonic, concave regression or ANOVA under partial orderings, just to name a few, can be considered as particular instances of the cone regression problem. Given its relevance in Statistics, this paper aims to address the fundamentals of cone regression from a theoretical and practical point of view. Several formulations of the cone regression problem are considered and, focusing on the particular case of concave regression as an example, several algorithms are analyzed and compared both qualitatively and quantitatively through numerical simulations. Several improvements to enhance numerical stability and bound the computational cost are proposed. For each analyzed algorithm, the pseudo-code and its corresponding code in Matlab are provided. The results from this study demonstrate that the choice of the optimization approach strongly impacts the numerical performances. It is also shown that methods are not currently available to solve efficiently cone regression problems with large dimension (more than many thousands of points). We suggest further research to fill this gap by exploiting and adapting classical multi-scale strategy to compute an approximate solution.
Keywords: cone regression; linear complementarity problems; proximal operators.
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Jean-Pascal Jacob, Mariella Dimiccoli, & L. Moisan. (2017). Active skeleton for bacteria modelling. CMBBE - Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization, 5(4), 274–286.
Abstract: The investigation of spatio-temporal dynamics of bacterial cells and their molecular components requires automated image analysis tools to track cell shape properties and molecular component locations inside the cells. In the study of bacteria aging, the molecular components of interest are protein aggregates accumulated near bacteria boundaries. This particular location makes very ambiguous the correspondence between aggregates and cells, since computing accurately bacteria boundaries in phase-contrast time-lapse imaging is a challenging task. This paper proposes an active skeleton formulation for bacteria modelling which provides several advantages: an easy computation of shape properties (perimeter, length, thickness and orientation), an improved boundary accuracy in noisy images and a natural bacteria-centred coordinate system that permits the intrinsic location of molecular components inside the cell. Starting from an initial skeleton estimate, the medial axis of the bacterium is obtained by minimising an energy function which incorporates bacteria shape constraints. Experimental results on biological images and comparative evaluation of the performances validate the proposed approach for modelling cigar-shaped bacteria like Escherichia coli. The Image-J plugin of the proposed method can be found online at http://fluobactracker.inrialpes.fr.
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Mariella Dimiccoli, Benoît Girard, Alain Berthoz, & Daniel Bennequin. (2013). Striola Magica: a functional explanation of otolith organs. JCN - Journal of Computational Neuroscience, 35(2), 125–154.
Abstract: Otolith end organs of vertebrates sense linear accelerations of the head and gravitation. The hair cells on their epithelia are responsible for transduction. In mammals, the striola, parallel to the line where hair cells reverse their polarization, is a narrow region centered on a curve with curvature and torsion. It has been shown that the striolar region is functionally different from the rest, being involved in a phasic vestibular pathway. We propose a mathematical and computational model that explains the necessity of this amazing geometry for the striola to be able to carry out its function. Our hypothesis, related to the biophysics of the hair cells and to the physiology of their afferent neurons, is that striolar afferents collect information from several type I hair cells to detect the jerk in a large domain of acceleration directions. This predicts a mean number of two calyces for afferent neurons, as measured in rodents. The domain of acceleration directions sensed by our striolar model is compatible with the experimental results obtained on monkeys considering all afferents. Therefore, the main result of our study is that phasic and tonic vestibular afferents cover the same geometrical fields, but at different dynamical and frequency domains.
Keywords: Otolith organs ;Striola; Vestibular pathway
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Maria Salamo, Inmaculada Rodriguez, Maite Lopez, Anna Puig, Simone Balocco, & Mariona Taule. (2016). Recurso docente para la atención de la diversidad en el aula mediante la predicción de notas. ReVision.
Abstract: Desde la implantación del Espacio Europeo de Educación Superior (EEES) en los diferentes grados, se ha puesto de manifiesto la necesidad de utilizar diversos mecanismos que permitan tratar la diversidad en el aula, evaluando automáticamente y proporcionando una retroalimentación rápida tanto al alumnado como al profesorado sobre la evolución de los alumnos en una asignatura. En este artículo se presenta la evaluación de la exactitud en las predicciones de GRADEFORESEER, un recurso docente para la predicción de notas basado en técnicas de aprendizaje automático que permite evaluar la evolución del alumnado y estimar su nota final al terminar el curso. Este recurso se ha complementado con una interfaz de usuario para el profesorado que puede ser usada en diferentes plataformas software (sistemas operativos) y en cualquier asignatura de un grado en la que se utilice evaluación continuada. Además de la descripción del recurso, este artículo presenta los resultados obtenidos al aplicar el sistema de predicción en cuatro asignaturas de disciplinas distintas: Programación I (PI), Diseño de Software (DSW) del grado de Ingeniería Informática, Tecnologías de la Información y la Comunicación (TIC) del grado de Lingüística y la asignatura Fundamentos de Tecnología (FDT) del grado de Información y Documentación, todas ellas impartidas en la Universidad de Barcelona.
La capacidad predictiva se ha evaluado de forma binaria (aprueba o no) y según un criterio de rango (suspenso, aprobado, notable o sobresaliente), obteniendo mejores predicciones en los resultados evaluados de forma binaria.
Keywords: Aprendizaje automatico; Sistema de prediccion de notas; Herramienta docente
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