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Francesco Ciompi, Oriol Pujol, Carlo Gatta, Marina Alberti, Simone Balocco, Xavier Carrillo, et al. (2012). HoliMab: A Holistic Approach for Media-Adventitia Border Detection in Intravascular Ultrasound. MIA - Medical Image Analysis, 16(6), 1085–1100.
Abstract: We present a fully automatic methodology for the detection of the Media-Adventitia border (MAb) in human coronary artery in Intravascular Ultrasound (IVUS) images. A robust border detection is achieved by means of a holistic interpretation of the detection problem where the target object, i.e. the media layer, is considered as part of the whole vessel in the image and all the relationships between tissues are learnt. A fairly general framework exploiting multi-class tissue characterization as well as contextual information on the morphology and the appearance of the tissues is presented. The methodology is (i) validated through an exhaustive comparison with both Inter-observer variability on two challenging databases and (ii) compared with state-of-the-art methods for the detection of the MAb in IVUS. The obtained averaged values for the mean radial distance and the percentage of area difference are 0.211 mm and 10.1%, respectively. The applicability of the proposed methodology to clinical practice is also discussed.
Keywords: Media–Adventitia border detection; Intravascular ultrasound; Multi-Scale Stacked Sequential Learning; Error-correcting output codes; Holistic segmentation
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Oriol Pujol, & David Masip. (2009). Geometry-Based Ensembles: Toward a Structural Characterization of the Classification Boundary. TPAMI - IEEE Transactions on Pattern Analysis and Machine Intelligence, 31(6), 1140–1146.
Abstract: This article introduces a novel binary discriminative learning technique based on the approximation of the non-linear decision boundary by a piece-wise linear smooth additive model. The decision border is geometrically defined by means of the characterizing boundary points – points that belong to the optimal boundary under a certain notion of robustness. Based on these points, a set of locally robust linear classifiers is defined and assembled by means of a Tikhonov regularized optimization procedure in an additive model to create a final lambda-smooth decision rule. As a result, a very simple and robust classifier with a strong geometrical meaning and non-linear behavior is obtained. The simplicity of the method allows its extension to cope with some of nowadays machine learning challenges, such as online learning, large scale learning or parallelization, with linear computational complexity. We validate our approach on the UCI database. Finally, we apply our technique in online and large scale scenarios, and in six real life computer vision and pattern recognition problems: gender recognition, intravascular ultrasound tissue classification, speed traffic sign detection, Chagas' disease severity detection, clef classification and action recognition using a 3D accelerometer data. The results are promising and this paper opens a line of research that deserves further attention
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Jose Seabra, Francesco Ciompi, Oriol Pujol, Josepa Mauri, Petia Radeva, & Joao Sanchez. (2011). Rayleigh Mixture Model for Plaque Characterization in Intravascular Ultrasound. TBME - IEEE Transactions on Biomedical Engineering, 58(5), 1314–1324.
Abstract: Vulnerable plaques are the major cause of carotid and coronary vascular problems, such as heart attack or stroke. A correct modeling of plaque echomorphology and composition can help the identification of such lesions. The Rayleigh distribution is widely used to describe (nearly) homogeneous areas in ultrasound images. Since plaques may contain tissues with heterogeneous regions, more complex distributions depending on multiple parameters are usually needed, such as Rice, K or Nakagami distributions. In such cases, the problem formulation becomes more complex, and the optimization procedure to estimate the plaque echomorphology is more difficult. Here, we propose to model the tissue echomorphology by means of a mixture of Rayleigh distributions, known as the Rayleigh mixture model (RMM). The problem formulation is still simple, but its ability to describe complex textural patterns is very powerful. In this paper, we present a method for the automatic estimation of the RMM mixture parameters by means of the expectation maximization algorithm, which aims at characterizing tissue echomorphology in ultrasound (US). The performance of the proposed model is evaluated with a database of in vitro intravascular US cases. We show that the mixture coefficients and Rayleigh parameters explicitly derived from the mixture model are able to accurately describe different plaque types and to significantly improve the characterization performance of an already existing methodology.
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Miguel Reyes, Albert Clapes, Jose Ramirez, Juan R Revilla, & Sergio Escalera. (2013). Automatic Digital Biometry Analysis based on Depth Maps. COMPUTIND - Computers in Industry, 64(9), 1316–1325.
Abstract: World Health Organization estimates that 80% of the world population is affected by back-related disorders during his life. Current practices to analyze musculo-skeletal disorders (MSDs) are expensive, subjective, and invasive. In this work, we propose a tool for static body posture analysis and dynamic range of movement estimation of the skeleton joints based on 3D anthropometric information from multi-modal data. Given a set of keypoints, RGB and depth data are aligned, depth surface is reconstructed, keypoints are matched, and accurate measurements about posture and spinal curvature are computed. Given a set of joints, range of movement measurements is also obtained. Moreover, gesture recognition based on joint movements is performed to look for the correctness in the development of physical exercises. The system shows high precision and reliable measurements, being useful for posture reeducation purposes to prevent MSDs, as well as tracking the posture evolution of patients in rehabilitation treatments.
Keywords: Multi-modal data fusion; Depth maps; Posture analysis; Anthropometric data; Musculo-skeletal disorders; Gesture analysis
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Antonio Hernandez, Carlo Gatta, Sergio Escalera, Laura Igual, Victoria Martin-Yuste, Manel Sabate, et al. (2012). Accurate coronary centerline extraction, caliber estimation and catheter detection in angiographies. TITB - IEEE Transactions on Information Technology in Biomedicine, 16(6), 1332–1340.
Abstract: Segmentation of coronary arteries in X-Ray angiography is a fundamental tool to evaluate arterial diseases and choose proper coronary treatment. The accurate segmentation of coronary arteries has become an important topic for the registration of different modalities which allows physicians rapid access to different medical imaging information from Computed Tomography (CT) scans or Magnetic Resonance Imaging (MRI). In this paper, we propose an accurate fully automatic algorithm based on Graph-cuts for vessel centerline extraction, caliber estimation, and catheter detection. Vesselness, geodesic paths, and a new multi-scale edgeness map are combined to customize the Graph-cuts approach to the segmentation of tubular structures, by means of a global optimization of the Graph-cuts energy function. Moreover, a novel supervised learning methodology that integrates local and contextual information is proposed for automatic catheter detection. We evaluate the method performance on three datasets coming from different imaging systems. The method performs as good as the expert observer w.r.t. centerline detection and caliber estimation. Moreover, the method discriminates between arteries and catheter with an accuracy of 96.5%, sensitivity of 72%, and precision of 97.4%.
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