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Xavier Carrillo, E Fernandez-Nofrerias, Francesco Ciompi, O. Rodriguez-Leor, Petia Radeva, Neus Salvatella, et al. (2011). Changes in Radial Artery Volume Assessed Using Intravascular Ultrasound: A Comparison of Two Vasodilator Regimens in Transradial Coronary Intervention. JOIC - Journal of Invasive Cardiology, 23(10), 401–404.
Abstract: OBJECTIVES:
This study used intravascular ultrasound (IVUS) to evaluate radial artery volume changes after intraarterial administration of nitroglycerin and/or verapamil.
BACKGROUND:
Radial artery spasm, which is associated with radial artery size, is the main limitation of the transradial approach in percutaneous coronary interventions (PCI).
METHODS:
This prospective, randomized study compared the effect of two intra-arterial vasodilator regimens on radial artery volume: 0.2 mg of nitroglycerin plus 2.5 mg of verapamil (Group 1; n = 15) versus 2.5 mg of verapamil alone (Group 2; n = 15). Radial artery lumen volume was assessed using IVUS at two time points: at baseline (5 minutes after sheath insertion) and post-vasodilator (1 minute after drug administration). The luminal volume of the radial artery was computed using ECOC Random Fields (ECOC-RF), a technique used for automatic segmentation of luminal borders in longitudinal cut images from IVUS sequences.
RESULTS:
There was a significant increase in arterial lumen volume in both groups, with an increase from 451 ± 177 mm³ to 508 ± 192 mm³ (p = 0.001) in Group 1 and from 456 ± 188 mm³ to 509 ± 170 mm³ (p = 0.001) in Group 2. There were no significant differences between the groups in terms of absolute volume increase (58 mm³ versus 53 mm³, respectively; p = 0.65) or in relative volume increase (14% versus 20%, respectively; p = 0.69).
CONCLUSIONS:
Administration of nitroglycerin plus verapamil or verapamil alone to the radial artery resulted in similar increases in arterial lumen volume according to ECOC-RF IVUS measurements.
Keywords: radial; vasodilator treatment; percutaneous coronary intervention; IVUS; volumetric IVUS analysis
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Frederic Sampedro, Anna Domenech, Sergio Escalera, & Ignasi Carrio. (2017). Computing quantitative indicators of structural renal damage in pediatric DMSA scans. REMNIM - Revista Española de Medicina Nuclear e Imagen Molecular, 36(2), 72–77.
Abstract: OBJECTIVES:
The proposal and implementation of a computational framework for the quantification of structural renal damage from 99mTc-dimercaptosuccinic acid (DMSA) scans. The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-independent manner.
MATERIALS AND METHODS:
From a set of 16 pediatric DMSA-positive scans and 16 matched controls and using both expert-guided and automatic approaches, a set of image-derived quantitative indicators was computed based on the relative size, intensity and histogram distribution of the lesion. A correlation analysis was conducted in order to investigate the association of these indicators with other clinical data of interest in this scenario, including C-reactive protein (CRP), white cell count, vesicoureteral reflux, fever, relative perfusion, and the presence of renal sequelae in a 6-month follow-up DMSA scan.
RESULTS:
A fully automatic lesion detection and segmentation system was able to successfully classify DMSA-positive from negative scans (AUC=0.92, sensitivity=81% and specificity=94%). The image-computed relative size of the lesion correlated with the presence of fever and CRP levels (p<0.05), and a measurement derived from the distribution histogram of the lesion obtained significant performance results in the detection of permanent renal damage (AUC=0.86, sensitivity=100% and specificity=75%).
CONCLUSIONS:
The proposal and implementation of a computational framework for the quantification of structural renal damage from DMSA scans showed a promising potential to complement visual diagnosis and non-imaging indicators.
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Frederic Sampedro, Anna Domenech, Sergio Escalera, & Ignasi Carrio. (2015). Deriving global quantitative tumor response parameters from 18F-FDG PET-CT scans in patients with non-Hodgkins lymphoma. NMC - Nuclear Medicine Communications, 36(4), 328–333.
Abstract: OBJECTIVES:
The aim of the study was to address the need for quantifying the global cancer time evolution magnitude from a pair of time-consecutive positron emission tomography-computed tomography (PET-CT) scans. In particular, we focus on the computation of indicators using image-processing techniques that seek to model non-Hodgkin's lymphoma (NHL) progression or response severity.
MATERIALS AND METHODS:
A total of 89 pairs of time-consecutive PET-CT scans from NHL patients were stored in a nuclear medicine station for subsequent analysis. These were classified by a consensus of nuclear medicine physicians into progressions, partial responses, mixed responses, complete responses, and relapses. The cases of each group were ordered by magnitude following visual analysis. Thereafter, a set of quantitative indicators designed to model the cancer evolution magnitude within each group were computed using semiautomatic and automatic image-processing techniques. Performance evaluation of the proposed indicators was measured by a correlation analysis with the expert-based visual analysis.
RESULTS:
The set of proposed indicators achieved Pearson's correlation results in each group with respect to the expert-based visual analysis: 80.2% in progressions, 77.1% in partial response, 68.3% in mixed response, 88.5% in complete response, and 100% in relapse. In the progression and mixed response groups, the proposed indicators outperformed the common indicators used in clinical practice [changes in metabolic tumor volume, mean, maximum, peak standardized uptake value (SUV mean, SUV max, SUV peak), and total lesion glycolysis] by more than 40%.
CONCLUSION:
Computing global indicators of NHL response using PET-CT imaging techniques offers a strong correlation with the associated expert-based visual analysis, motivating the future incorporation of such quantitative and highly observer-independent indicators in oncological decision making or treatment response evaluation scenarios.
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Gerard Canal, Sergio Escalera, & Cecilio Angulo. (2016). A Real-time Human-Robot Interaction system based on gestures for assistive scenarios. CVIU - Computer Vision and Image Understanding, 149, 65–77.
Abstract: Natural and intuitive human interaction with robotic systems is a key point to develop robots assisting people in an easy and effective way. In this paper, a Human Robot Interaction (HRI) system able to recognize gestures usually employed in human non-verbal communication is introduced, and an in-depth study of its usability is performed. The system deals with dynamic gestures such as waving or nodding which are recognized using a Dynamic Time Warping approach based on gesture specific features computed from depth maps. A static gesture consisting in pointing at an object is also recognized. The pointed location is then estimated in order to detect candidate objects the user may refer to. When the pointed object is unclear for the robot, a disambiguation procedure by means of either a verbal or gestural dialogue is performed. This skill would lead to the robot picking an object in behalf of the user, which could present difficulties to do it by itself. The overall system — which is composed by a NAO and Wifibot robots, a KinectTM v2 sensor and two laptops — is firstly evaluated in a structured lab setup. Then, a broad set of user tests has been completed, which allows to assess correct performance in terms of recognition rates, easiness of use and response times.
Keywords: Gesture recognition; Human Robot Interaction; Dynamic Time Warping; Pointing location estimation
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Sergio Escalera, Alicia Fornes, O. Pujol, Petia Radeva, Gemma Sanchez, & Josep Llados. (2009). Blurred Shape Model for Binary and Grey-level Symbol Recognition. PRL - Pattern Recognition Letters, 30(15), 1424–1433.
Abstract: Many symbol recognition problems require the use of robust descriptors in order to obtain rich information of the data. However, the research of a good descriptor is still an open issue due to the high variability of symbols appearance. Rotation, partial occlusions, elastic deformations, intra-class and inter-class variations, or high variability among symbols due to different writing styles, are just a few problems. In this paper, we introduce a symbol shape description to deal with the changes in appearance that these types of symbols suffer. The shape of the symbol is aligned based on principal components to make the recognition invariant to rotation and reflection. Then, we present the Blurred Shape Model descriptor (BSM), where new features encode the probability of appearance of each pixel that outlines the symbols shape. Moreover, we include the new descriptor in a system to deal with multi-class symbol categorization problems. Adaboost is used to train the binary classifiers, learning the BSM features that better split symbol classes. Then, the binary problems are embedded in an Error-Correcting Output Codes framework (ECOC) to deal with the multi-class case. The methodology is evaluated on different synthetic and real data sets. State-of-the-art descriptors and classifiers are compared, showing the robustness and better performance of the present scheme to classify symbols with high variability of appearance.
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