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Frederic Sampedro, Sergio Escalera, Anna Domenech, & Ignasi Carrio. (2014). A computational framework for cancer response assessment based on oncological PET-CT scans. CBM - Computers in Biology and Medicine, 55, 92–99.
Abstract: In this work we present a comprehensive computational framework to help in the clinical assessment of cancer response from a pair of time consecutive oncological PET-CT scans. In this scenario, the design and implementation of a supervised machine learning system to predict and quantify cancer progression or response conditions by introducing a novel feature set that models the underlying clinical context is described. Performance results in 100 clinical cases (corresponding to 200 whole body PET-CT scans) in comparing expert-based visual analysis and classifier decision making show up to 70% accuracy within a completely automatic pipeline and 90% accuracy when providing the system with expert-guided PET tumor segmentation masks.
Keywords: Computer aided diagnosis; Nuclear medicine; Machine learning; Image processing; Quantitative analysis
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Frederic Sampedro, Sergio Escalera, & Anna Puig. (2014). Iterative Multiclass Multiscale Stacked Sequential Learning: definition and application to medical volume segmentation. PRL - Pattern Recognition Letters, 46, 1–10.
Abstract: In this work we present the iterative multi-class multi-scale stacked sequential learning framework (IMMSSL), a novel learning scheme that is particularly suited for medical volume segmentation applications. This model exploits the inherent voxel contextual information of the structures of interest in order to improve its segmentation performance results. Without any feature set or learning algorithm prior assumption, the proposed scheme directly seeks to learn the contextual properties of a region from the predicted classifications of previous classifiers within an iterative scheme. Performance results regarding segmentation accuracy in three two-class and multi-class medical volume datasets show a significant improvement with respect to state of the art alternatives. Due to its easiness of implementation and its independence of feature space and learning algorithm, the presented machine learning framework could be taken into consideration as a first choice in complex volume segmentation scenarios.
Keywords: Machine learning; Sequential learning; Multi-class problems; Contextual learning; Medical volume segmentation
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Pierluigi Casale, Oriol Pujol, & Petia Radeva. (2014). Approximate polytope ensemble for one-class classification. PR - Pattern Recognition, 47(2), 854–864.
Abstract: In this work, a new one-class classification ensemble strategy called approximate polytope ensemble is presented. The main contribution of the paper is threefold. First, the geometrical concept of convex hull is used to define the boundary of the target class defining the problem. Expansions and contractions of this geometrical structure are introduced in order to avoid over-fitting. Second, the decision whether a point belongs to the convex hull model in high dimensional spaces is approximated by means of random projections and an ensemble decision process. Finally, a tiling strategy is proposed in order to model non-convex structures. Experimental results show that the proposed strategy is significantly better than state of the art one-class classification methods on over 200 datasets.
Keywords: One-class classification; Convex hull; High-dimensionality; Random projections; Ensemble learning
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Mariella Dimiccoli, Jean-Pascal Jacob, & Lionel Moisan. (2016). Particle detection and tracking in fluorescence time-lapse imaging: a contrario approach. MVAP - Journal of Machine Vision and Applications, 27, 511–527.
Abstract: In this work, we propose a probabilistic approach for the detection and the
tracking of particles on biological images. In presence of very noised and poor
quality data, particles and trajectories can be characterized by an a-contrario
model, that estimates the probability of observing the structures of interest
in random data. This approach, first introduced in the modeling of human visual
perception and then successfully applied in many image processing tasks, leads
to algorithms that do not require a previous learning stage, nor a tedious
parameter tuning and are very robust to noise. Comparative evaluations against
a well established baseline show that the proposed approach outperforms the
state of the art.
Keywords: particle detection; particle tracking; a-contrario approach; time-lapse fluorescence imaging
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Santiago Segui, Michal Drozdzal, Ekaterina Zaytseva, Fernando Azpiroz, Petia Radeva, & Jordi Vitria. (2014). Detection of wrinkle frames in endoluminal videos using betweenness centrality measures for images. TITB - IEEE Transactions on Information Technology in Biomedicine, 18(6), 1831–1838.
Abstract: Intestinal contractions are one of the most important events to diagnose motility pathologies of the small intestine. When visualized by wireless capsule endoscopy (WCE), the sequence of frames that represents a contraction is characterized by a clear wrinkle structure in the central frames that corresponds to the folding of the intestinal wall. In this paper we present a new method to robustly detect wrinkle frames in full WCE videos by using a new mid-level image descriptor that is based on a centrality measure proposed for graphs. We present an extended validation, carried out in a very large database, that shows that the proposed method achieves state of the art performance for this task.
Keywords: Wireless Capsule Endoscopy; Small Bowel Motility Dysfunction; Contraction Detection; Structured Prediction; Betweenness Centrality
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