Abstract: Accurate detection of in-vivo vulnerable plaque in coronary arteries is still an open problem. Recent studies show that it is highly related to tissue structure and composition. Intravascular Ultrasound (IVUS) is a powerful imaging technique that gives a detailed cross-sectional image of the vessel, allowing to explore arteries morphology. IVUS data validation is usually performed by comparing post-mortem (in-vitro) IVUS data and corresponding histological analysis of the tissue. The main drawback of this method is the few number of available case studies and validated data due to the complex procedure of histological analysis of the tissue. On the other hand, IVUS data from in-vivo cases is easy to obtain but it can not be histologically validated. In this work, we propose to enhance the in-vitro training data set by selectively including examples from in-vivo plaques. For this purpose, a Sequential Floating Forward Selection method is reformulated in the context of plaque characterization. The enhanced classifier performance is validated on in-vitro data set, yielding an overall accuracy of 91.59% in discriminating among fibrotic, lipidic and calcified plaques, while reducing the gap between in-vivo and in-vitro data analysis. Experimental results suggest that the obtained classifier could be properly applied on in-vivo plaque characterization and also demonstrate that the common hypothesis of assuming the difference between in-vivo and in-vitro as negligible is incorrect.

Abstract: A standard way to deal with multi-class categorization problems is by the combination of binary classifiers in a pairwise voting procedure. Recently, this classical approach has been formalized in the Error-Correcting Output Codes (ECOC) framework. In the ECOC framework, the one-versus-one coding demonstrates to achieve higher performance than the rest of coding designs. The binary problems that we train in the one-versus-one strategy are significantly smaller than in the rest of designs, and usually easier to be learnt, taking into account the smaller overlapping between classes. However, a high percentage of the positions coded by zero of the coding matrix, which implies a high sparseness degree, does not codify meta-class membership information. In this paper, we show that using the training data we can redefine without re-training, in a problem-dependent way, the one-versus-one coding matrix so that the new coded information helps the system to increase its generalization capability. Moreover, the new re-coding strategy is generalized to be applied over any binary code. The results over several UCI Machine Learning repository data sets and two real multi-class problems show that performance improvements can be obtained re-coding the classical one-versus-one and Sparse random designs compared to different state-of-the-art ECOC configurations.