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Albert Andaluz, Francesc Carreras, Debora Gil, & Jaume Garcia. (2010). "Una aplicació amigable pel càlcul de indicadors clínics del ventricle esquerre ". Barcelona: Biocat.
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Jaume Garcia, Albert Andaluz, Debora Gil, & Francesc Carreras. (2010). "Decoupled External Forces in a Predictor-Corrector Segmentation Scheme for LV Contours in Tagged MR Images " In 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 4805–4808).
Abstract: Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictorcorrector (Active Contours – Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores.
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Mariano Vazquez, Ruth Aris, Guillaume Hozeaux, R.Aubry, P.Villar, Jaume Garcia, et al. (2011). "A massively parallel computational electrophysiology model of the heart " . International Journal for Numerical Methods in Biomedical Engineering, 27, 1911–1929.
Abstract: This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale.
Keywords: computational electrophysiology; parallelization; finite element methods
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David Roche, Debora Gil, & Jesus Giraldo. (2012). "Assessing agonist efficacy in an uncertain Em world " In A. Christopoulus and M. Bouvier (Ed.), 40th Keystone Symposia on mollecular and celular biology (79). Keystone Symposia.
Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
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Esmitt Ramirez, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2018). "BronchoX: bronchoscopy exploration software for biopsy intervention planning " . Healthcare Technology Letters, 5(5), 177–182.
Abstract: Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.
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Ernest Valveny, & Enric Marti. (2000). "Deformable Template Matching within a Bayesian Framework for Hand-Written Graphic Symbol Recognition " . Graphics Recognition Recent Advances, 1941, 193–208.
Abstract: We describe a method for hand-drawn symbol recognition based on deformable template matching able to handle uncertainty and imprecision inherent to hand-drawing. Symbols are represented as a set of straight lines and their deformations as geometric transformations of these lines. Matching, however, is done over the original binary image to avoid loss of information during line detection. It is defined as an energy minimization problem, using a Bayesian framework which allows to combine fidelity to ideal shape of the symbol and flexibility to modify the symbol in order to get the best fit to the binary input image. Prior to matching, we find the best global transformation of the symbol to start the recognition process, based on the distance between symbol lines and image lines. We have applied this method to the recognition of dimensions and symbols in architectural floor plans and we show its flexibility to recognize distorted symbols.
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Eric Amiel. (2005). "Visualisation de vaisseaux sanguins " (Enric Marti, Ed.). Bachelor's thesis, Université Paul Sabatier Toulouse III, Toulouse.
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