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Author |
Frederic Sampedro; Anna Domenech; Sergio Escalera; Ignasi Carrio |
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Title |
Deriving global quantitative tumor response parameters from 18F-FDG PET-CT scans in patients with non-Hodgkins lymphoma |
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Journal Article |
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Year |
2015 |
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Nuclear Medicine Communications |
Abbreviated Journal |
NMC |
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36 |
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4 |
Pages |
328-333 |
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Abstract |
OBJECTIVES:
The aim of the study was to address the need for quantifying the global cancer time evolution magnitude from a pair of time-consecutive positron emission tomography-computed tomography (PET-CT) scans. In particular, we focus on the computation of indicators using image-processing techniques that seek to model non-Hodgkin's lymphoma (NHL) progression or response severity.
MATERIALS AND METHODS:
A total of 89 pairs of time-consecutive PET-CT scans from NHL patients were stored in a nuclear medicine station for subsequent analysis. These were classified by a consensus of nuclear medicine physicians into progressions, partial responses, mixed responses, complete responses, and relapses. The cases of each group were ordered by magnitude following visual analysis. Thereafter, a set of quantitative indicators designed to model the cancer evolution magnitude within each group were computed using semiautomatic and automatic image-processing techniques. Performance evaluation of the proposed indicators was measured by a correlation analysis with the expert-based visual analysis.
RESULTS:
The set of proposed indicators achieved Pearson's correlation results in each group with respect to the expert-based visual analysis: 80.2% in progressions, 77.1% in partial response, 68.3% in mixed response, 88.5% in complete response, and 100% in relapse. In the progression and mixed response groups, the proposed indicators outperformed the common indicators used in clinical practice [changes in metabolic tumor volume, mean, maximum, peak standardized uptake value (SUV mean, SUV max, SUV peak), and total lesion glycolysis] by more than 40%.
CONCLUSION:
Computing global indicators of NHL response using PET-CT imaging techniques offers a strong correlation with the associated expert-based visual analysis, motivating the future incorporation of such quantitative and highly observer-independent indicators in oncological decision making or treatment response evaluation scenarios. |
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HuPBA;MILAB |
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Admin @ si @ SDE2015 |
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2605 |
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Andres Traumann; Gholamreza Anbarjafari; Sergio Escalera |
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Title |
Accurate 3D Measurement Using Optical Depth Information |
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Journal Article |
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Year |
2015 |
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Electronic Letters |
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EL |
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51 |
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18 |
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1420-1422 |
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A novel three-dimensional measurement technique is proposed. The methodology consists in mapping from the screen coordinates reported by the optical camera to the real world, and integrating distance gradients from the beginning to the end point, while also minimising the error through fitting pixel locations to a smooth curve. The results demonstrate accuracy of less than half a centimetre using Microsoft Kinect II. |
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HuPBA;MILAB |
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Admin @ si @ TAE2015 |
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2647 |
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Xavier Perez Sala; Fernando De la Torre; Laura Igual; Sergio Escalera; Cecilio Angulo |
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Title |
Subspace Procrustes Analysis |
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Journal Article |
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2017 |
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International Journal of Computer Vision |
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IJCV |
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121 |
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3 |
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327–343 |
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Procrustes Analysis (PA) has been a popular technique to align and build 2-D statistical models of shapes. Given a set of 2-D shapes PA is applied to remove rigid transformations. Then, a non-rigid 2-D model is computed by modeling (e.g., PCA) the residual. Although PA has been widely used, it has several limitations for modeling 2-D shapes: occluded landmarks and missing data can result in local minima solutions, and there is no guarantee that the 2-D shapes provide a uniform sampling of the 3-D space of rotations for the object. To address previous issues, this paper proposes Subspace PA (SPA). Given several
instances of a 3-D object, SPA computes the mean and a 2-D subspace that can simultaneously model all rigid and non-rigid deformations of the 3-D object. We propose a discrete (DSPA) and continuous (CSPA) formulation for SPA, assuming that 3-D samples of an object are provided. DSPA extends the traditional PA, and produces unbiased 2-D models by uniformly sampling different views of the 3-D object. CSPA provides a continuous approach to uniformly sample the space of 3-D rotations, being more efficient in space and time. Experiments using SPA to learn 2-D models of bodies from motion capture data illustrate the benefits of our approach. |
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MILAB; HuPBA; no proj |
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no |
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Admin @ si @ PTI2017 |
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2841 |
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Frederic Sampedro; Anna Domenech; Sergio Escalera; Ignasi Carrio |
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Title |
Computing quantitative indicators of structural renal damage in pediatric DMSA scans |
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Journal Article |
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Year |
2017 |
Publication |
Revista Española de Medicina Nuclear e Imagen Molecular |
Abbreviated Journal |
REMNIM |
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36 |
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2 |
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72-77 |
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OBJECTIVES:
The proposal and implementation of a computational framework for the quantification of structural renal damage from 99mTc-dimercaptosuccinic acid (DMSA) scans. The aim of this work is to propose, implement, and validate a computational framework for the quantification of structural renal damage from DMSA scans and in an observer-independent manner.
MATERIALS AND METHODS:
From a set of 16 pediatric DMSA-positive scans and 16 matched controls and using both expert-guided and automatic approaches, a set of image-derived quantitative indicators was computed based on the relative size, intensity and histogram distribution of the lesion. A correlation analysis was conducted in order to investigate the association of these indicators with other clinical data of interest in this scenario, including C-reactive protein (CRP), white cell count, vesicoureteral reflux, fever, relative perfusion, and the presence of renal sequelae in a 6-month follow-up DMSA scan.
RESULTS:
A fully automatic lesion detection and segmentation system was able to successfully classify DMSA-positive from negative scans (AUC=0.92, sensitivity=81% and specificity=94%). The image-computed relative size of the lesion correlated with the presence of fever and CRP levels (p<0.05), and a measurement derived from the distribution histogram of the lesion obtained significant performance results in the detection of permanent renal damage (AUC=0.86, sensitivity=100% and specificity=75%).
CONCLUSIONS:
The proposal and implementation of a computational framework for the quantification of structural renal damage from DMSA scans showed a promising potential to complement visual diagnosis and non-imaging indicators. |
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HuPBA;MILAB; no menciona |
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Admin @ si @ SDE2017 |
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2842 |
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Author |
Mikkel Thogersen; Sergio Escalera; Jordi Gonzalez; Thomas B. Moeslund |
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Title |
Segmentation of RGB-D Indoor scenes by Stacking Random Forests and Conditional Random Fields |
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Journal Article |
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2016 |
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Pattern Recognition Letters |
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PRL |
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80 |
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208–215 |
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This paper proposes a technique for RGB-D scene segmentation using Multi-class
Multi-scale Stacked Sequential Learning (MMSSL) paradigm. Following recent trends in state-of-the-art, a base classifier uses an initial SLIC segmentation to obtain superpixels which provide a diminution of data while retaining object boundaries. A series of color and depth features are extracted from the superpixels, and are used in a Conditional Random Field (CRF) to predict superpixel labels. Furthermore, a Random Forest (RF) classifier using random offset features is also used as an input to the CRF, acting as an initial prediction. As a stacked classifier, another Random Forest is used acting on a spatial multi-scale decomposition of the CRF confidence map to correct the erroneous labels assigned by the previous classifier. The model is tested on the popular NYU-v2 dataset.
The approach shows that simple multi-modal features with the power of the MMSSL
paradigm can achieve better performance than state of the art results on the same dataset. |
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HuPBA; ISE;MILAB; 600.098; 600.119 |
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Admin @ si @ TEG2016 |
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2843 |
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