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Author Pau Cano; Alvaro Caravaca; Debora Gil; Eva Musulen edit   pdf
url  openurl
  Title Diagnosis of Helicobacter pylori using AutoEncoders for the Detection of Anomalous Staining Patterns in Immunohistochemistry Images Type Miscellaneous
  Year (down) 2023 Publication Arxiv Abbreviated Journal  
  Volume Issue Pages 107241  
  Keywords  
  Abstract This work addresses the detection of Helicobacter pylori a bacterium classified since 1994 as class 1 carcinogen to humans. By its highest specificity and sensitivity, the preferred diagnosis technique is the analysis of histological images with immunohistochemical staining, a process in which certain stained antibodies bind to antigens of the biological element of interest. This analysis is a time demanding task, which is currently done by an expert pathologist that visually inspects the digitized samples.
We propose to use autoencoders to learn latent patterns of healthy tissue and detect H. pylori as an anomaly in image staining. Unlike existing classification approaches, an autoencoder is able to learn patterns in an unsupervised manner (without the need of image annotations) with high performance. In particular, our model has an overall 91% of accuracy with 86\% sensitivity, 96% specificity and 0.97 AUC in the detection of H. pylori.
 
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  Notes IAM Approved no  
  Call Number Admin @ si @ CCG2023 Serial 3855  
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Author Juan Borrego-Carazo; Carles Sanchez; David Castells; Jordi Carrabina; Debora Gil edit   pdf
doi  openurl
  Title BronchoPose: an analysis of data and model configuration for vision-based bronchoscopy pose estimation Type Journal Article
  Year (down) 2023 Publication Computer Methods and Programs in Biomedicine Abbreviated Journal CMPB  
  Volume 228 Issue Pages 107241  
  Keywords Videobronchoscopy guiding; Deep learning; Architecture optimization; Datasets; Standardized evaluation framework; Pose estimation  
  Abstract Vision-based bronchoscopy (VB) models require the registration of the virtual lung model with the frames from the video bronchoscopy to provide effective guidance during the biopsy. The registration can be achieved by either tracking the position and orientation of the bronchoscopy camera or by calibrating its deviation from the pose (position and orientation) simulated in the virtual lung model. Recent advances in neural networks and temporal image processing have provided new opportunities for guided bronchoscopy. However, such progress has been hindered by the lack of comparative experimental conditions.
In the present paper, we share a novel synthetic dataset allowing for a fair comparison of methods. Moreover, this paper investigates several neural network architectures for the learning of temporal information at different levels of subject personalization. In order to improve orientation measurement, we also present a standardized comparison framework and a novel metric for camera orientation learning. Results on the dataset show that the proposed metric and architectures, as well as the standardized conditions, provide notable improvements to current state-of-the-art camera pose estimation in video bronchoscopy.
 
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number Admin @ si @ BSC2023 Serial 3702  
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Author Guillermo Torres; Debora Gil; Antoni Rosell; S. Mena; Carles Sanchez edit  openurl
  Title Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules – Intermediate Results of the RadioLung Project Type Journal Article
  Year (down) 2023 Publication International Journal of Computer Assisted Radiology and Surgery Abbreviated Journal IJCARS  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number Admin @ si @ TGM2023 Serial 3830  
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Author Guillermo Torres; Jan Rodríguez Dueñas; Sonia Baeza; Antoni Rosell; Carles Sanchez; Debora Gil edit   pdf
url  openurl
  Title Prediction of Malignancy in Lung Cancer using several strategies for the fusion of Multi-Channel Pyradiomics Images Type Conference Article
  Year (down) 2023 Publication 7th Workshop on Digital Image Processing for Medical and Automotive Industry in the framework of SYNASC 2023 Abbreviated Journal  
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  Abstract This study shows the generation process and the subsequent study of the representation space obtained by extracting GLCM texture features from computer-aided tomography (CT) scans of pulmonary nodules (PN). For this, data from 92 patients from the Germans Trias i Pujol University Hospital were used. The workflow focuses on feature extraction using Pyradiomics and the VGG16 Convolutional Neural Network (CNN). The aim of the study is to assess whether the data obtained have a positive impact on the diagnosis of lung cancer (LC). To design a machine learning (ML) model training method that allows generalization, we train SVM and neural network (NN) models, evaluating diagnosis performance using metrics defined at slice and nodule level.  
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  ISSN ISBN Medium  
  Area Expedition Conference DIPMAI  
  Notes IAM Approved no  
  Call Number Admin @ si @ TRB2023 Serial 3926  
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Author Guillermo Torres; Debora Gil; Antoni Rosell; S. Mena; Carles Sanchez edit  openurl
  Title Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules Type Conference Article
  Year (down) 2023 Publication 37th International Congress and Exhibition is organized by Computer Assisted Radiology and Surgery Abbreviated Journal  
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  Address Munich; Germany; June 2023  
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  ISSN ISBN Medium  
  Area Expedition Conference CARS  
  Notes IAM Approved no  
  Call Number Admin @ si @ TGR2023a Serial 3950  
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Author Sonia Baeza; Debora Gil; Carles Sanchez; Guillermo Torres; Ignasi Garcia Olive; Ignasi Guasch; Samuel Garcia Reina; Felipe Andreo; Jose Luis Mate; Jose Luis Vercher; Antonio Rosell edit  openurl
  Title Biopsia virtual radiomica para el diagnóstico histológico de nódulos pulmonares – Resultados intermedios del proyecto Radiolung Type Conference Article
  Year (down) 2023 Publication SEPAR Abbreviated Journal  
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  Address Granada; Spain; June 2023  
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  ISSN ISBN Medium  
  Area Expedition Conference SEPAR  
  Notes IAM Approved no  
  Call Number Admin @ si @ BGS2023 Serial 3951  
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Author Debora Gil; Guillermo Torres; Carles Sanchez edit  openurl
  Title Transforming radiomic features into radiological words Type Conference Article
  Year (down) 2023 Publication IEEE International Symposium on Biomedical Imaging Abbreviated Journal  
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  Abstract Pòster  
  Address Cartagena de Indias; Colombia; April 2023  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number Admin @ si @ GTS2023 Serial 3952  
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Author Pau Cano; Debora Gil; Eva Musulen edit  openurl
  Title Towards automatic detection of helicobacter pylori in histological samples of gastric tissue Type Conference Article
  Year (down) 2023 Publication IEEE International Symposium on Biomedical Imaging Abbreviated Journal  
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  Address Cartagena de Indias; Colombia; April 2023  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number Admin @ si @ CGM2023 Serial 3953  
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Author Guillermo Torres; Debora Gil; Antonio Rosell; Sonia Baeza; Carles Sanchez edit  openurl
  Title A radiomic biopsy for virtual histology of pulmonary nodules Type Conference Article
  Year (down) 2023 Publication IEEE International Symposium on Biomedical Imaging Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Pòster  
  Address Cartagena de Indias; Colombia; April 2023  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number Admin @ si @ TGR2023b Serial 3954  
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Author Miquel Angel Piera; Jose Luis Muñoz; Debora Gil; Gonzalo Martin; Jordi Manzano edit  doi
openurl 
  Title A Socio-Technical Simulation Model for the Design of the Future Single Pilot Cockpit: An Opportunity to Improve Pilot Performance Type Journal Article
  Year (down) 2022 Publication IEEE Access Abbreviated Journal ACCESS  
  Volume 10 Issue Pages 22330-22343  
  Keywords Human factors ; Performance evaluation ; Simulation; Sociotechnical systems ; System performance  
  Abstract The future deployment of single pilot operations must be supported by new cockpit computer services. Such services require an adaptive context-aware integration of technical functionalities with the concurrent tasks that a pilot must deal with. Advanced artificial intelligence supporting services and improved communication capabilities are the key enabling technologies that will render future cockpits more integrated with the present digitalized air traffic management system. However, an issue in the integration of such technologies is the lack of socio-technical analysis in the design of these teaming mechanisms. A key factor in determining how and when a service support should be provided is the dynamic evolution of pilot workload. This paper investigates how the socio-technical model-based systems engineering approach paves the way for the design of a digital assistant framework by formalizing this workload. The model was validated in an Airbus A-320 cockpit simulator, and the results confirmed the degraded pilot behavioral model and the performance impact according to different contextual flight deck information. This study contributes to practical knowledge for designing human-machine task-sharing systems.  
  Address Feb 2022  
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  Notes IAM; Approved no  
  Call Number Admin @ si @ PMG2022 Serial 3697  
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Author Guillermo Torres; Sonia Baeza; Carles Sanchez; Ignasi Guasch; Antoni Rosell; Debora Gil edit  doi
openurl 
  Title An Intelligent Radiomic Approach for Lung Cancer Screening Type Journal Article
  Year (down) 2022 Publication Applied Sciences Abbreviated Journal APPLSCI  
  Volume 12 Issue 3 Pages 1568  
  Keywords Lung cancer; Early diagnosis; Screening; Neural networks; Image embedding; Architecture optimization  
  Abstract The efficiency of lung cancer screening for reducing mortality is hindered by the high rate of false positives. Artificial intelligence applied to radiomics could help to early discard benign cases from the analysis of CT scans. The available amount of data and the fact that benign cases are a minority, constitutes a main challenge for the successful use of state of the art methods (like deep learning), which can be biased, over-fitted and lack of clinical reproducibility. We present an hybrid approach combining the potential of radiomic features to characterize nodules in CT scans and the generalization of the feed forward networks. In order to obtain maximal reproducibility with minimal training data, we propose an embedding of nodules based on the statistical significance of radiomic features for malignancy detection. This representation space of lesions is the input to a feed
forward network, which architecture and hyperparameters are optimized using own-defined metrics of the diagnostic power of the whole system. Results of the best model on an independent set of patients achieve 100% of sensitivity and 83% of specificity (AUC = 0.94) for malignancy detection.
 
  Address Jan 2022  
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  Notes IAM; 600.139; 600.145 Approved no  
  Call Number Admin @ si @ TBS2022 Serial 3699  
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Author Oriol Ramos Terrades; Albert Berenguel; Debora Gil edit   pdf
doi  openurl
  Title A Flexible Outlier Detector Based on a Topology Given by Graph Communities Type Journal Article
  Year (down) 2022 Publication Big Data Research Abbreviated Journal BDR  
  Volume 29 Issue Pages 100332  
  Keywords Classification algorithms; Detection algorithms; Description of feature space local structure; Graph communities; Machine learning algorithms; Outlier detectors  
  Abstract Outlier detection is essential for optimal performance of machine learning methods and statistical predictive models. Their detection is especially determinant in small sample size unbalanced problems, since in such settings outliers become highly influential and significantly bias models. This particular experimental settings are usual in medical applications, like diagnosis of rare pathologies, outcome of experimental personalized treatments or pandemic emergencies. In contrast to population-based methods, neighborhood based local approaches compute an outlier score from the neighbors of each sample, are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. A main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters, like the number of neighbors.
This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world and synthetic data sets show that our approach outperforms, both, local and global strategies in multi and single view settings.
 
  Address August 28, 2022  
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  Notes DAG; IAM; 600.140; 600.121; 600.139; 600.145; 600.159 Approved no  
  Call Number Admin @ si @ RBG2022a Serial 3718  
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Author Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; B. Cardenas; G. Fonseka; E. Anton; Alvaro Pascual; Richard Frodsham; Zaida Sarrate edit  doi
openurl 
  Title Time to match; when do homologous chromosomes become closer? Type Journal Article
  Year (down) 2022 Publication Chromosoma Abbreviated Journal CHRO  
  Volume Issue Pages  
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  Abstract In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions.  
  Address August, 2022  
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  Area Expedition Conference  
  Notes IAM; 601.139; 600.145; 600.096 Approved no  
  Call Number Admin @ si @ SBG2022 Serial 3719  
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Author Aura Hernandez-Sabate; Jose Elias Yauri; Pau Folch; Miquel Angel Piera; Debora Gil edit  doi
openurl 
  Title Recognition of the Mental Workloads of Pilots in the Cockpit Using EEG Signals Type Journal Article
  Year (down) 2022 Publication Applied Sciences Abbreviated Journal APPLSCI  
  Volume 12 Issue 5 Pages 2298  
  Keywords Cognitive states; Mental workload; EEG analysis; Neural networks; Multimodal data fusion  
  Abstract The commercial flightdeck is a naturally multi-tasking work environment, one in which interruptions are frequent come in various forms, contributing in many cases to aviation incident reports. Automatic characterization of pilots’ workloads is essential to preventing these kind of incidents. In addition, minimizing the physiological sensor network as much as possible remains both a challenge and a requirement. Electroencephalogram (EEG) signals have shown high correlations with specific cognitive and mental states, such as workload. However, there is not enough evidence in the literature to validate how well models generalize in cases of new subjects performing tasks with workloads similar to the ones included during the model’s training. In this paper, we propose a convolutional neural network to classify EEG features across different mental workloads in a continuous performance task test that partly measures working memory and working memory capacity. Our model is valid at the general population level and it is able to transfer task learning to pilot mental workload recognition in a simulated operational environment.  
  Address February 2022  
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  Notes IAM; ADAS; 600.139; 600.145; 600.118 Approved no  
  Call Number Admin @ si @ HYF2022 Serial 3720  
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Author Debora Gil; Aura Hernandez-Sabate; Julien Enconniere; Saryani Asmayawati; Pau Folch; Juan Borrego-Carazo; Miquel Angel Piera edit  doi
openurl 
  Title E-Pilots: A System to Predict Hard Landing During the Approach Phase of Commercial Flights Type Journal Article
  Year (down) 2022 Publication IEEE Access Abbreviated Journal ACCESS  
  Volume 10 Issue Pages 7489-7503  
  Keywords  
  Abstract More than half of all commercial aircraft operation accidents could have been prevented by executing a go-around. Making timely decision to execute a go-around manoeuvre can potentially reduce overall aviation industry accident rate. In this paper, we describe a cockpit-deployable machine learning system to support flight crew go-around decision-making based on the prediction of a hard landing event.
This work presents a hybrid approach for hard landing prediction that uses features modelling temporal dependencies of aircraft variables as inputs to a neural network. Based on a large dataset of 58177 commercial flights, the results show that our approach has 85% of average sensitivity with 74% of average specificity at the go-around point. It follows that our approach is a cockpit-deployable recommendation system that outperforms existing approaches.
 
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  Area Expedition Conference  
  Notes IAM; 600.139; 600.118; 600.145 Approved no  
  Call Number Admin @ si @ GHE2022 Serial 3721  
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