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Author Debora Gil; Ruth Aris; Agnes Borras; Esmitt Ramirez; Rafael Sebastian; Mariano Vazquez edit  doi
openurl 
  Title Influence of fiber connectivity in simulations of cardiac biomechanics Type Journal Article
  Year (down) 2019 Publication International Journal of Computer Assisted Radiology and Surgery Abbreviated Journal IJCAR  
  Volume 14 Issue 1 Pages 63–72  
  Keywords Cardiac electromechanical simulations; Diffusion tensor imaging; Fiber connectivity  
  Abstract PURPOSE:
Personalized computational simulations of the heart could open up new improved approaches to diagnosis and surgery assistance systems. While it is fully recognized that myocardial fiber orientation is central for the construction of realistic computational models of cardiac electromechanics, the role of its overall architecture and connectivity remains unclear. Morphological studies show that the distribution of cardiac muscular fibers at the basal ring connects epicardium and endocardium. However, computational models simplify their distribution and disregard the basal loop. This work explores the influence in computational simulations of fiber distribution at different short-axis cuts.

METHODS:
We have used a highly parallelized computational solver to test different fiber models of ventricular muscular connectivity. We have considered two rule-based mathematical models and an own-designed method preserving basal connectivity as observed in experimental data. Simulated cardiac functional scores (rotation, torsion and longitudinal shortening) were compared to experimental healthy ranges using generalized models (rotation) and Mahalanobis distances (shortening, torsion).

RESULTS:
The probability of rotation was significantly lower for ruled-based models [95% CI (0.13, 0.20)] in comparison with experimental data [95% CI (0.23, 0.31)]. The Mahalanobis distance for experimental data was in the edge of the region enclosing 99% of the healthy population.

CONCLUSIONS:
Cardiac electromechanical simulations of the heart with fibers extracted from experimental data produce functional scores closer to healthy ranges than rule-based models disregarding architecture connectivity.
 
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  Notes IAM; 600.096; 601.323; Approved no  
  Call Number Admin @ si @ GAB2019 Serial 3133  
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Author Debora Gil; Rosa Maria Ortiz; Carles Sanchez; Antoni Rosell edit  doi
openurl 
  Title Objective endoscopic measurements of central airway stenosis. A pilot study Type Journal Article
  Year (down) 2018 Publication Respiration Abbreviated Journal RES  
  Volume 95 Issue Pages 63–69  
  Keywords Bronchoscopy; Tracheal stenosis; Airway stenosis; Computer-assisted analysis  
  Abstract Endoscopic estimation of the degree of stenosis in central airway obstruction is subjective and highly variable. Objective: To determine the benefits of using SENSA (System for Endoscopic Stenosis Assessment), an image-based computational software, for obtaining objective stenosis index (SI) measurements among a group of expert bronchoscopists and general pulmonologists. Methods: A total of 7 expert bronchoscopists and 7 general pulmonologists were enrolled to validate SENSA usage. The SI obtained by the physicians and by SENSA were compared with a reference SI to set their precision in SI computation. We used SENSA to efficiently obtain this reference SI in 11 selected cases of benign stenosis. A Web platform with three user-friendly microtasks was designed to gather the data. The users had to visually estimate the SI from videos with and without contours of the normal and the obstructed area provided by SENSA. The users were able to modify the SENSA contours to define the reference SI using morphometric bronchoscopy. Results: Visual SI estimation accuracy was associated with neither bronchoscopic experience (p = 0.71) nor the contours of the normal and the obstructed area provided by the system (p = 0.13). The precision of the SI by SENSA was 97.7% (95% CI: 92.4-103.7), which is significantly better than the precision of the SI by visual estimation (p < 0.001), with an improvement by at least 15%. Conclusion: SENSA provides objective SI measurements with a precision of up to 99.5%, which can be calculated from any bronchoscope using an affordable scalable interface. Providing normal and obstructed contours on bronchoscopic videos does not improve physicians' visual estimation of the SI.  
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  Notes IAM; 600.075; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ GOS2018 Serial 3043  
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Author Esmitt Ramirez; Carles Sanchez; Agnes Borras; Marta Diez Ferrer; Antoni Rosell; Debora Gil edit   pdf
url  openurl
  Title BronchoX: bronchoscopy exploration software for biopsy intervention planning Type Journal Article
  Year (down) 2018 Publication Healthcare Technology Letters Abbreviated Journal HTL  
  Volume 5 Issue 5 Pages 177–182  
  Keywords  
  Abstract Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.  
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  Area Expedition Conference  
  Notes IAM; 600.096; 600.075; 601.323; 601.337; 600.145 Approved no  
  Call Number Admin @ si @ RSB2018a Serial 3132  
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Author Marta Diez Ferrer; Arturo Morales; Rosa Lopez Lisbona; Noelia Cubero; Cristian Tebe; Susana Padrones; Samantha Aso; Jordi Dorca; Debora Gil; Antoni Rosell edit  url
openurl 
  Title Ultrathin Bronchoscopy with and without Virtual Bronchoscopic Navigation: Influence of Segmentation on Diagnostic Yield Type Journal Article
  Year (down) 2018 Publication Respiration Abbreviated Journal RES  
  Volume 97 Issue 3 Pages 252-258  
  Keywords Lung cancer; Peripheral lung lesion; Diagnosis; Bronchoscopy; Ultrathin bronchoscopy; Virtual bronchoscopic navigation  
  Abstract Background: Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs. Objectives: We aimed to compare the diagnostic yield of VBN-guided and unguided ultrathin bronchoscopy (UTB) and explore clinical and technical factors associated with better results. We developed a diagnostic algorithm for deciding whether to use VBN to reach PPLs or choose an alternative diagnostic approach. Methods: We compared diagnostic yield between VBN-UTB (prospective cases) and unguided UTB (historical controls) and analyzed the VBN-UTB subgroup to identify clinical and technical variables that could predict the success of VBN-UTB. Results: Fifty-five cases and 110 controls were included. The overall diagnostic yield did not differ between the VBN-guided and unguided arms (47 and 40%, respectively; p = 0.354). Although the yield was slightly higher for PPLs ≤20 mm in the VBN-UTB arm, the difference was not significant (p = 0.069). No other clinical characteristics were associated with a higher yield in a subgroup analysis, but an 85% diagnostic yield was observed when segmentation was optimal and the PPL was endobronchial (vs. 30% when segmentation was suboptimal and 20% when segmentation was optimal but the PPL was extrabronchial). Conclusions: VBN-guided UTB is not superior to unguided UTB. A greater impact of VBN-guided over unguided UTB is highly dependent on both segmentation quality and an endobronchial location of the PPL. Segmentation quality should be considered before starting a procedure, when an alternative technique that may improve yield can be chosen, saving time and resources.  
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  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ DML2018 Serial 3134  
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Author Marta Diez Ferrer; Debora Gil; Cristian Tebe; Carles Sanchez edit   pdf
doi  openurl
  Title Positive Airway Pressure to Enhance Computed Tomography Imaging for Airway Segmentation for Virtual Bronchoscopic Navigation Type Journal Article
  Year (down) 2018 Publication Respiration Abbreviated Journal RES  
  Volume 96 Issue 6 Pages 525-534  
  Keywords Multidetector computed tomography; Bronchoscopy; Continuous positive airway pressure; Image enhancement; Virtual bronchoscopic navigation  
  Abstract Abstract
RATIONALE:
Virtual bronchoscopic navigation (VBN) guidance to peripheral pulmonary lesions is often limited by insufficient segmentation of the peripheral airways.

OBJECTIVES:
To test the effect of applying positive airway pressure (PAP) during CT acquisition to improve segmentation, particularly at end-expiration.

METHODS:
CT acquisitions in inspiration and expiration with 4 PAP protocols were recorded prospectively and compared to baseline inspiratory acquisitions in 20 patients. The 4 protocols explored differences between devices (flow vs. turbine), exposures (within seconds vs. 15-min) and pressure levels (10 vs. 14 cmH2O). Segmentation quality was evaluated with the number of airways and number of endpoints reached. A generalized mixed-effects model explored the estimated effect of each protocol.

MEASUREMENTS AND MAIN RESULTS:
Patient characteristics and lung function did not significantly differ between protocols. Compared to baseline inspiratory acquisitions, expiratory acquisitions after 15 min of 14 cmH2O PAP segmented 1.63-fold more airways (95% CI 1.07-2.48; p = 0.018) and reached 1.34-fold more endpoints (95% CI 1.08-1.66; p = 0.004). Inspiratory acquisitions performed immediately under 10 cmH2O PAP reached 1.20-fold (95% CI 1.09-1.33; p < 0.001) more endpoints; after 15 min the increase was 1.14-fold (95% CI 1.05-1.24; p < 0.001).

CONCLUSIONS:
CT acquisitions with PAP segment more airways and reach more endpoints than baseline inspiratory acquisitions. The improvement is particularly evident at end-expiration after 15 min of 14 cmH2O PAP. Further studies must confirm that the improvement increases diagnostic yield when using VBN to evaluate peripheral pulmonary lesions.
 
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  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ DGT2018 Serial 3135  
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Author Debora Gil; Sergio Vera; Agnes Borras; Albert Andaluz; Miguel A. Gonzalez Ballester edit   pdf
doi  openurl
  Title Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities Type Journal Article
  Year (down) 2017 Publication Medical Image Analysis Abbreviated Journal MIA  
  Volume 35 Issue Pages 390-402  
  Keywords Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points  
  Abstract Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies.  
  Address  
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  Publisher Elsevier B.V. Place of Publication Editor  
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  Notes IAM; 600.060; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GVB2017 Serial 2775  
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Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso edit  url
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type Journal Article
  Year (down) 2017 Publication Journal of Thoracic Oncology Abbreviated Journal JTO  
  Volume 12 Issue 1S Pages S596-S597  
  Keywords Thorax CT; diagnosis; Peripheral Pulmonary Nodule  
  Abstract A main weakness of virtual bronchoscopic navigation (VBN) is unsuccessful segmentation of distal branches approaching peripheral pulmonary nodules (PPN). CT scan acquisition protocol is pivotal for segmentation covering the utmost periphery. We hypothesize that application of continuous positive airway pressure (CPAP) during CT acquisition could improve visualization and segmentation of peripheral bronchi. The purpose of the present pilot study is to compare quality of segmentations under 4 CT acquisition modes: inspiration (INSP), expiration (EXP) and both with CPAP (INSP-CPAP and EXP-CPAP).  
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  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ DGC2017a Serial 2883  
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Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso; Vanesa Vicens; Noelia Cubero de Frutos; Rosa Lopez Lisbona; Carles Sanchez; Agnes Borras; Antoni Rosell edit  doi
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type Journal Article
  Year (down) 2017 Publication European Respiratory Journal Abbreviated Journal ERJ  
  Volume 48 Issue 60 Pages PA776  
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  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ DGC2017b Serial 2944  
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Author Mireia Sole; Joan Blanco; Debora Gil; Gothami Fonseka; Richard Frodsham; Francesca Vidal; Zaida Sarrate edit   pdf
isbn  openurl
  Title Noves perspectives en l’estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals Type Journal
  Year (down) 2017 Publication Biologia de la Reproduccio Abbreviated Journal JBR  
  Volume 15 Issue Pages 73-78  
  Keywords  
  Abstract In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation.
 
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-84-697-3767-5 Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ SBG2017c Serial 2961  
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Author Mireia Sole; Joan Blanco; Debora Gil; Gothami Fonseka; Richard Frodsham; Oliver Valero; Francesca Vidal; Zaida Sarrate edit  openurl
  Title Análisis 3d de la territorialidad cromosómica en células espermatogénicas: explorando la infertilidad desde un nuevo prisma Type Journal
  Year (down) 2017 Publication Revista Asociación para el Estudio de la Biología de la Reproducción Abbreviated Journal ASEBIR  
  Volume 22 Issue 2 Pages 105  
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  Notes IAM; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ SBG2017d Serial 3042  
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