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Author David Roche; Debora Gil; Jesus Giraldo edit   pdf
url  openurl
  Title (up) Assessing agonist efficacy in an uncertain Em world Type Conference Article
  Year 2012 Publication 40th Keystone Symposia on mollecular and celular biology Abbreviated Journal  
  Volume Issue Pages 79  
  Keywords  
  Abstract The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
 
  Address Fairmont Banff Springs, Banff, Alberta, Canada  
  Corporate Author Keystone Symposia Thesis  
  Publisher Keystone Symposia Place of Publication Editor A. Christopoulus and M. Bouvier  
  Language english Summary Language english Original Title  
  Series Editor Keystone Symposia Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference KSMCB  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGG2012 Serial 1855  
Permanent link to this record
 

 
Author Debora Gil; Petia Radeva; Jordi Saludes; Josefina Mauri edit   pdf
url  openurl
  Title (up) Automatic Segmentation of Artery Wall in Coronary IVUS Images: A Probabilistic Approach Type Conference Article
  Year 2000 Publication International Conference on Pattern Recognition Abbreviated Journal  
  Volume 4 Issue Pages 352-355  
  Keywords  
  Abstract Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GRS2000a Serial 1537  
Permanent link to this record
 

 
Author Debora Gil; Petia Radeva; Jordi Saludes; Josefina Mauri edit   pdf
openurl 
  Title (up) Automatic Segmentation of Artery Wall in Coronary IVUS Images: a Probabilistic Approach Type Conference Article
  Year 2000 Publication Proceedings of CIC’2000 Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Cambridge, Massachussets Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CIC  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GRS2000 Serial 1538  
Permanent link to this record
 

 
Author Josefina Mauri; Eduard Fernandez-Nofrerias; J. Comin; B. Garcia del Blanco; E. Iraculis; J.A. Gomez-Hospital; P. Valdovinos; F. Jara; A. Cequier; E. Esplugas; Oriol Pujol; Cristina Cañero; Debora Gil; Petia Radeva; Ricardo Toledo edit  openurl
  Title (up) Avaluació del Conjunt Stent/Artèria mitjançant ecografia intracoronària: lentorn informàtic Type Conference Article
  Year 2000 Publication Congrés de la Societat Catalana de Cardiologia. Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;RV;MILAB;ADAS;HuPBA Approved no  
  Call Number IAM @ iam @ MNC2000 Serial 1622  
Permanent link to this record
 

 
Author Carles Sanchez; Miguel Viñas; Coen Antens; Agnes Borras; Debora Gil edit   pdf
url  doi
openurl 
  Title (up) Back to Front Architecture for Diagnosis as a Service Type Conference Article
  Year 2018 Publication 20th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing Abbreviated Journal  
  Volume Issue Pages 343-346  
  Keywords  
  Abstract Software as a Service (SaaS) is a cloud computing model in which a provider hosts applications in a server that customers use via internet. Since SaaS does not require to install applications on customers' own computers, it allows the use by multiple users of highly specialized software without extra expenses for hardware acquisition or licensing. A SaaS tailored for clinical needs not only would alleviate licensing costs, but also would facilitate easy access to new methods for diagnosis assistance. This paper presents a SaaS client-server architecture for Diagnosis as a Service (DaaS). The server is based on docker technology in order to allow execution of softwares implemented in different languages with the highest portability and scalability. The client is a content management system allowing the design of websites with multimedia content and interactive visualization of results allowing user editing. We explain a usage case that uses our DaaS as crowdsourcing platform in a multicentric pilot study carried out to evaluate the clinical benefits of a software for assessment of central airway obstruction.  
  Address Timisoara; Rumania; September 2018  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference SYNASC  
  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ SVA2018 Serial 3360  
Permanent link to this record
 

 
Author Oriol Rodriguez-Leon; Debora Gil; Eduard Fernandez-Nofrerias; H.Tizon; S.Montserrat; Vicente del Valle;Josefina Mauri edit  openurl
  Title (up) Caracterització de la Perfusió Miocàrdica mitjançant anàlisi estadístic de l espectre en l angiografia de contrast Type Conference Article
  Year 2007 Publication XIX Congrés de la Societat Catalana de Cardiologia de Barcelona Abbreviated Journal  
  Volume Issue Pages 130  
  Keywords  
  Abstract La valoració de la integritat de la microcirculació coronària aporta informació pronòstica en pacients amb infart agut de miocardi en els que es realitza angioplastia primària. Aquesta valoració és subjectiva i presenta una important variabilitat si no es duta a terme per personal experimentat. Presentem una eina d’anàlisi d’imatge que permet fer una valoració de la microcirculació coronària a partir de seqüències d’angiografia. Hem analitzat les variacions locals en el nivell de gris de la imatge durant la seqüència angiogràfica. Hem identificat els principals fenòmens observats (respiració, batec cardíac, tinció arterial, tinció miocàrdica i soroll radiològic) mitjançant un anàlisi estadístic de l’espectre de Fourier de l’evolució al llarg del temps de la mitja local. Aquest mateix anàlisis permet determinat la influència de cadascun d’ells en la extracció del patró de tinció i selecciona la respiració com el fenomen que més distorsiona el patró de tinció original. Els descriptors proposats s’obtenen fora del rang espectral respiratori. Hem testat la seva capacitat per a detectar els tres fenòmens principals (tinció miocàrdica (MS), tinció arterial (AS) i soroll (NS)) independentment de la respiració. La capacitat de discriminació dels descriptors ha estat valorada mitjançant un mètode de crossvalidation en 30 seqüències d’angiografia. Els descriptors emprats permeten caracteritzar la tinció miocàrdica amb una alta eficiència i fiabilitat. A més no hi ha diferències significatives en l’anàlisi de les seqüències obtingudes amb el pacient respirant amb normalitat o en apnea  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Barcelona (Spain) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGF2007 Serial 1639  
Permanent link to this record
 

 
Author Jaume Garcia; Debora Gil; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
openurl 
  Title (up) Characterization of ventricular torsion in healthy subjects using Gabor filters and a variational framework Type Conference Article
  Year 2006 Publication Proc. Computers in Cardiology Abbreviated Journal  
  Volume Issue Pages 877-880  
  Keywords  
  Abstract In this work, we present a fully automated method for tissue deformation estimation in tagged magnetic resonance images (TMRI). Gabor filter banks, tuned independently for each left ventricle level, provide optimally filtered complex images which phase remains constant along the cardiac cycle. This fact can be thought as the brightness constancy condition required by classical optical flow (OF) methods. Pairs of these filtered sequences, together with a variational formulation are used in a second step to obtain dense continuous deformation maps that we call Harmonic Phase Flow. This method has been used to determine reference values of ventricular torsion (VT) in a set of 8 healthy volunteers. The results encourage the use of VT as a useful parameter for ventricular function assessment in clinical routine.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GGB2006a Serial 1509  
Permanent link to this record
 

 
Author Mireia Sole; J. Blanco; Debora Gil; Oliver Valero; Gothami Fonseka; M. Lawrie; Francesca Vidal; Zaida Sarrate edit   pdf
openurl 
  Title (up) Chromosome Territories in Mice Spermatogenesis: A new three-dimensional methodology of study Type Conference Article
  Year 2017 Publication 11th European CytoGenesis Conference Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address Florencia; Italia; July 2017  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ECA  
  Notes IAM; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ SBG2017a Serial 2936  
Permanent link to this record
 

 
Author Debora Gil; Oriol Ramos Terrades; Elisa Minchole; Carles Sanchez; Noelia Cubero de Frutos; Marta Diez-Ferrer; Rosa Maria Ortiz; Antoni Rosell edit   pdf
url  openurl
  Title (up) Classification of Confocal Endomicroscopy Patterns for Diagnosis of Lung Cancer Type Conference Article
  Year 2017 Publication 6th Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging Abbreviated Journal  
  Volume 10550 Issue Pages 151-159  
  Keywords  
  Abstract Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.

The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.

We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results.
 
  Address Quebec; Canada; September 2017  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CLIP  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GRM2017 Serial 2957  
Permanent link to this record
 

 
Author Rosa Maria Ortiz; Debora Gil; Elisa Minchole; Marta Diez-Ferrer; Noelia Cubero de Frutos edit   pdf
openurl 
  Title (up) Classification of Confolcal Endomicroscopy Patterns for Diagnosis of Lung Cancer Type Conference Article
  Year 2017 Publication 18th World Conference on Lung Cancer Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.

The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.

We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results.
 
  Address Yokohama; Japan; October 2017  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference IASLC WCLC  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ OGM2017 Serial 3044  
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