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Author |
Debora Gil; Agnes Borras; Manuel Ballester; Francesc Carreras; Ruth Aris; Manuel Vazquez; Enric Marti; Ferran Poveda |
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Title |
MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis |
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Conference Article |
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Year |
2011 |
Publication |
14th International Symposium on Applied Sciences in Biomedical and Communication Technologies |
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Abstract |
Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization. |
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Address |
Barcelona; Spain |
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Corporate Author |
Association for Computing Machinery |
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Place of Publication |
Barcelona, Spain |
Editor |
Association for Computing Machinery |
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Language |
english |
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english |
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978-1-4503-0913-4 |
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ISABEL |
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Call Number |
IAM @ iam @ GGB2011 |
Serial |
1691 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Assessing agonist efficacy in an uncertain Em world |
Type |
Conference Article |
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Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
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79 |
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Abstract |
The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
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Address |
Fairmont Banff Springs, Banff, Alberta, Canada |
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Corporate Author |
Keystone Symposia |
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Keystone Symposia |
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Editor |
A. Christopoulus and M. Bouvier |
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english |
Summary Language |
english |
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Keystone Symposia |
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KSMCB |
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IAM |
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Call Number |
IAM @ iam @ RGG2012 |
Serial |
1855 |
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