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Author David Roche; Debora Gil; Jesus Giraldo edit   pdf
url  openurl
  Title Assessing agonist efficacy in an uncertain Em world Type Conference Article
  Year 2012 Publication 40th Keystone Symposia on mollecular and celular biology Abbreviated Journal  
  Volume Issue Pages 79  
  Keywords  
  Abstract The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
 
  Address Fairmont Banff Springs, Banff, Alberta, Canada  
  Corporate Author Keystone Symposia Thesis  
  Publisher Keystone Symposia Place of Publication Editor A. Christopoulus and M. Bouvier  
  Language english Summary Language english Original Title  
  Series Editor (down) Keystone Symposia Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference KSMCB  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGG2012 Serial 1855  
Permanent link to this record
 

 
Author Patricia Marquez; Debora Gil ; Aura Hernandez-Sabate edit   pdf
doi  isbn
openurl 
  Title Error Analysis for Lucas-Kanade Based Schemes Type Conference Article
  Year 2012 Publication 9th International Conference on Image Analysis and Recognition Abbreviated Journal  
  Volume 7324 Issue I Pages 184-191  
  Keywords Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance  
  Abstract Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures.  
  Address Aveiro, Portugal  
  Corporate Author Thesis  
  Publisher Springer-Verlag Berlin Heidelberg Place of Publication Editor  
  Language english Summary Language Original Title  
  Series Editor (down) Campilho, Aurélio and Kamel, Mohamed Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-31294-6 Medium  
  Area Expedition Conference ICIAR  
  Notes IAM Approved no  
  Call Number IAM @ iam @ MGH2012a Serial 1899  
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Author Joel Barajas; Jaume Garcia; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
url  isbn
openurl 
  Title Angle Images Using Gabor Filters in Cardiac Tagged MRI Type Conference Article
  Year 2005 Publication Proceeding of the 2005 conference on Artificial Intelligence Research and Development Abbreviated Journal  
  Volume Issue Pages 107-114  
  Keywords Angle Images, Gabor Filters, Harp, Tagged Mri  
  Abstract Tagged Magnetic Resonance Imaging (MRI) is a non-invasive technique used to examine cardiac deformation in vivo. An Angle Image is a representation of a Tagged MRI which recovers the relative position of the tissue respect to the distorted tags. Thus cardiac deformation can be estimated. This paper describes a new approach to generate Angle Images using a bank of Gabor filters in short axis cardiac Tagged MRI. Our method improves the Angle Images obtained by global techniques, like HARP, with a local frequency analysis. We propose to use the phase response of a combination of a Gabor filters bank, and use it to find a more precise deformation of the left ventricle. We demonstrate the accuracy of our method over HARP by several experimental results.  
  Address Amsterdam; The Netherlands  
  Corporate Author Thesis  
  Publisher IOS Press Place of Publication Amsterdam, The Netherlands Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 1-58603-560-6 Medium  
  Area Expedition Conference CAIRD  
  Notes IAM;MILAB Approved no  
  Call Number BCNPCL @ bcnpcl @ BGC2005; IAM @ iam Serial 595  
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Author Jaume Garcia; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
doi  isbn
openurl 
  Title An intuitive validation technique to compare local versus global tagged MRI analysis Type Conference Article
  Year 2005 Publication Computers In Cardiology Abbreviated Journal  
  Volume 32 Issue Pages 29–32  
  Keywords  
  Abstract Myocardium appears as a uniform tissue that seen in convectional Magnetic Resonance Images (MRI) shows just the contractile part of its movement. MR Tagging is a unique imaging technique that prints a grid over the tissue which moves according to the underlying movement of the myocardium revealing the true deformation of the cardiac muscle. Optical flow techniques based on spectral information estimate tissue displacement by analyzing information encoded in the phase maps which can be obtained using, local (Gabor) and global (HARP) methods. In this paper we compare both in synthetic and real Tagged MR sequences. We conclude that local method is slightly more accurate than the global one. On the other hand, global method is more efficient as it is much faster and less parameters have to be taken into account  
  Address Lyon (France)  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 0-7803-9337-6 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GBC2005 Serial 639  
Permanent link to this record
 

 
Author Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux edit   pdf
isbn  openurl
  Title Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function Type Conference Article
  Year 2008 Publication 8th World Congress on Computational Mechanichs (WCCM8) Abbreviated Journal  
  Volume Issue Pages  
  Keywords Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance.  
  Abstract Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.
 
  Address Venice; Italy  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 9788496736559 Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ GGV2008b Serial 993  
Permanent link to this record
 

 
Author C. Santa-Marta; Jaume Garcia; A. Bajo; J.J. Vaquero; M. Ledesma-Carbayo; Debora Gil edit  openurl
  Title Influence of the Temporal Resolution on the Quantification of Displacement Fields in Cardiac Magnetic Resonance Tagged Images Type Conference Article
  Year 2008 Publication XXVI Congreso Anual de la Sociedad Española de Ingenieria Biomedica Abbreviated Journal  
  Volume Issue Pages 352–353  
  Keywords  
  Abstract It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.  
  Address Valladolid  
  Corporate Author Thesis  
  Publisher Place of Publication Editor Roberto hornero, Saniel Abasolo  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CASEIB  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ SGB2008 Serial 1033  
Permanent link to this record
 

 
Author Joel Barajas; Jaume Garcia; Karla Lizbeth Caballero; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
isbn  openurl
  Title Correction of Misalignment Artifacts Among 2-D Cardiac MR Images in 3-D Space Type Conference Article
  Year 2006 Publication 1st International Wokshop on Computer Vision for Intravascular and Intracardiac Imaging (CVII’06) Abbreviated Journal  
  Volume 3217 Issue Pages 114-121  
  Keywords  
  Abstract Cardiac Magnetic Resonance images offer the opportunity to study the heart in detail. One of the main issues in its modelling is to create an accurate 3-D reconstruction of the left ventricle from 2-D views. A first step to achieve this goal is the correct registration among the different image planes due to patient movements. In this article, we present an accurate method to correct displacement artifacts using the Normalized Mutual Information. Here, the image views are treated as planes in order to diminish the approximation error caused by the association of a certain thickness, and moved simultaneously to avoid any kind of bias in the alignment process. This method has been validated using real and syntectic plane displacements, yielding promising results.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Copenhagen (Denmark) Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-540-22977-3 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ BGC2006 Serial 1485  
Permanent link to this record
 

 
Author Cristina Cañero; Petia Radeva; Oriol Pujol; Ricardo Toledo; Debora Gil; J. Saludes; Juan J. Villanueva; B. Garcia del Blanco; J. Mauri; E. Fernandez-Nofrerias; J.A. Gomez-Hospital; E. Iraculis; J. Comin; C. Quiles; F. Jara; A. Cequier; E. Esplugas edit   pdf
openurl 
  Title Optimal Stent Implantation: Three-dimensional Evaluation of the Mutual Position of Stent and Vessel via Intracoronary Ecography Type Conference Article
  Year 1999 Publication Proceedings of International Conference on Computer in Cardiology (CIC´99) Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract We present a new automatic technique to visualize and quantify the mutual position between the stent and the vessel wall by considering their three-dimensional reconstruction. Two deformable generalized cylinders adapt to the image features in all IVUS planes corresponding to the vessel wall and the stent in order to reconstruct the boundaries of the stent and the vessel in space. The image features that characterize the stent and the vessel wall are determined in terms of edge and ridge image detectors taking into account the gray level of the image pixels. We show that the 30 reconstruction by deformable cylinders is accurate and robust due to the spatial data coherence in the considered volumetric IVUS image. The main clinic utility of the stent and vessel reconstruction by deformable’ cylinders consists of its possibility to visualize and to assess the optimal stent introduction.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes MILAB; RV; IAM; ADAS; HuPBA Approved no  
  Call Number IAM @ iam @ CRP1999a Serial 1491  
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Author Cristina Cañero; Petia Radeva; Oriol Pujol; Ricardo Toledo; Debora Gil; J. Saludes; Juan J. Villanueva; B. Garcia del Blanco; Josefina Mauri; Eduard Fernandez-Nofrerias; J.A. Gomez-Hospital; E. Iraculis; J. Comin; C. Quiles; F. Jara; A. Cequier; E.Esplugas edit   pdf
openurl 
  Title Three-dimensional reconstruction and quantification of the coronary tree using intravascular ultrasound images Type Conference Article
  Year 1999 Publication Proceedings of International Conference on Computer in Cardiology (CIC´99) Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract In this paper we propose a new Computer Vision technique to reconstruct the vascular wall in space using a deformable model-based technique and compounding methods, based in biplane angiography and intravascular ultrasound data jicsion. It is also proposed a generalpurpose three-dimensional guided interpolation method. The three dimensional centerline of the vessel is reconstructed from geometrically corrected biplane angiographies using automatic segmentation methods and snakes. The IVUS image planes are located in the threedimensional space and correctly oriented. A led interpolation method based in B-SurJaces and snakes isused to fill the gaps among image planes  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CINC99  
  Notes MILAB;RV;IAM;ADAS;HuPBA Approved no  
  Call Number IAM @ iam @ CRP1999b Serial 1492  
Permanent link to this record
 

 
Author Enric Marti; Jordi Regincos; Jaime Lopez-Krahe; Juan J.Villanueva edit  openurl
  Title A system for interpretation of hand line drawings as three-dimensional scene for CAD input Type Conference Article
  Year 1991 Publication Proceedings of the First International Conference on Document Analysis and Recognition Abbreviated Journal  
  Volume Issue Pages 472-480  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (down) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;ISE Approved no  
  Call Number IAM @ iam @ Mar1991 Serial 1494  
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