toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
  Records Links
Author David Roche; Debora Gil; Jesus Giraldo edit   pdf
url  openurl
  Title Assessing agonist efficacy in an uncertain Em world Type Conference Article
  Year 2012 Publication 40th Keystone Symposia on mollecular and celular biology Abbreviated Journal  
  Volume Issue Pages 79  
  Keywords  
  Abstract The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
 
  Address Fairmont Banff Springs, Banff, Alberta, Canada  
  Corporate Author Keystone Symposia Thesis  
  Publisher Keystone Symposia Place of Publication Editor (up) A. Christopoulus and M. Bouvier  
  Language english Summary Language english Original Title  
  Series Editor Keystone Symposia Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference KSMCB  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGG2012 Serial 1855  
Permanent link to this record
 

 
Author Jaume Garcia; Debora Gil; A.Bajo; M.J.Ledesma-Carbayo; C.SantaMarta edit   pdf
doi  openurl
  Title Influence of the temporal resolution on the quantification of displacement fields in cardiac magnetic resonance tagged images Type Conference Article
  Year 2008 Publication Proc. Computers in Cardiology Abbreviated Journal  
  Volume 35 Issue Pages 785-788  
  Keywords  
  Abstract It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possible. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up) Alan Murray  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GGB2008 Serial 1508  
Permanent link to this record
 

 
Author Patricia Marquez;Debora Gil;Aura Hernandez-Sabate edit   pdf
doi  isbn
openurl 
  Title A Complete Confidence Framework for Optical Flow Type Conference Article
  Year 2012 Publication 12th European Conference on Computer Vision – Workshops and Demonstrations Abbreviated Journal  
  Volume 7584 Issue 2 Pages 124-133  
  Keywords Optical flow, confidence measures, sparsification plots, error prediction plots  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.  
  Address  
  Corporate Author Thesis  
  Publisher Springer-Verlag Place of Publication Florence, Italy, October 7-13, 2012 Editor (up) Andrea Fusiello, Vittorio Murino ,Rita Cucchiara  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-642-33867-0 Medium  
  Area Expedition Conference ECCVW  
  Notes IAM;ADAS; Approved no  
  Call Number IAM @ iam @ MGH2012b Serial 1991  
Permanent link to this record
 

 
Author Debora Gil; Agnes Borras; Manuel Ballester; Francesc Carreras; Ruth Aris; Manuel Vazquez; Enric Marti; Ferran Poveda edit   pdf
url  doi
isbn  openurl
  Title MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis Type Conference Article
  Year 2011 Publication 14th International Symposium on Applied Sciences in Biomedical and Communication Technologies Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.  
  Address Barcelona; Spain  
  Corporate Author Association for Computing Machinery Thesis  
  Publisher Place of Publication Barcelona, Spain Editor (up) Association for Computing Machinery  
  Language english Summary Language english Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-1-4503-0913-4 Medium  
  Area Expedition Conference ISABEL  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GGB2011 Serial 1691  
Permanent link to this record
 

 
Author Carles Sanchez; Jorge Bernal; Debora Gil; F. Javier Sanchez edit   pdf
doi  isbn
openurl 
  Title On-line lumen centre detection in gastrointestinal and respiratory endoscopy Type Conference Article
  Year 2013 Publication Second International Workshop Clinical Image-Based Procedures Abbreviated Journal  
  Volume 8361 Issue Pages 31-38  
  Keywords Lumen centre detection; Bronchoscopy; Colonoscopy  
  Abstract We present in this paper a novel lumen centre detection for gastrointestinal and respiratory endoscopic images. The proposed method is based on the appearance and geometry of the lumen, which we defined as the darkest image region which centre is a hub of image gradients. Experimental results validated on the first public annotated gastro-respiratory database prove the reliability of the method for a wide range of images (with precision over 95 %).  
  Address Nagoya; Japan; September 2013  
  Corporate Author Thesis  
  Publisher Springer International Publishing Place of Publication Editor (up) Erdt, Marius and Linguraru, Marius George and Oyarzun Laura, Cristina and Shekhar, Raj and Wesarg, Stefan and González Ballester, Miguel Angel and Drechsler, Klaus  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-319-05665-4 Medium  
  Area 800 Expedition Conference CLIP  
  Notes MV; IAM; 600.047; 600.044; 600.060 Approved no  
  Call Number Admin @ si @ SBG2013 Serial 2302  
Permanent link to this record
 

 
Author Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru edit  openurl
  Title Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs Type Conference Article
  Year 2011 Publication Workshop on Computational and Clinical Applications in Abdominal Imaging Abbreviated Journal  
  Volume 7029 Issue Pages 223-230  
  Keywords  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.  
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor (up) In H. Yoshida et al  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ABDI  
  Notes IAM; MV Approved no  
  Call Number VGB2011 Serial 2036  
Permanent link to this record
 

 
Author Debora Gil; Jaume Garcia; Ruth Aris; Guillaume Houzeaux; Manuel Vazquez edit   pdf
openurl 
  Title A Riemmanian approach to cardiac fiber architecture modelling Type Conference Article
  Year 2009 Publication 1st International Conference on Mathematical & Computational Biomedical Engineering Abbreviated Journal  
  Volume Issue Pages 59-62  
  Keywords cardiac fiber architecture; diffusion tensor magnetic resonance imaging; differential (Rie- mannian) geometry.  
  Abstract There is general consensus that myocardial fiber architecture should be modelled in order to fully understand the electromechanical properties of the Left Ventricle (LV). Diffusion Tensor magnetic resonance Imaging (DTI) is the reference image modality for rapid measurement of fiber orientations by means of the tensor principal eigenvectors. In this work, we present a mathematical framework for across subject comparison of the local geometry of the LV anatomy including the fiber architecture from the statistical analysis of DTI studies. We use concepts of differential geometry for defining a parametric domain suitable for statistical analysis of a low number of samples. We use Riemannian metrics to define a consistent computation of DTI principal eigenvector modes of variation. Our framework has been applied to build an atlas of the LV fiber architecture from 7 DTI normal canine hearts.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Swansea (UK) Editor (up) Nithiarasu, R.L.R.V.L.  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CMBE  
  Notes IAM Approved no  
  Call Number IAM @ iam @ FGA2009 Serial 1520  
Permanent link to this record
 

 
Author Aura Hernandez-Sabate; Debora Gil; David Roche; Monica M. S. Matsumoto; Sergio S. Furuie edit   pdf
url  openurl
  Title Inferring the Performance of Medical Imaging Algorithms Type Conference Article
  Year 2011 Publication 14th International Conference on Computer Analysis of Images and Patterns Abbreviated Journal  
  Volume 6854 Issue Pages 520-528  
  Keywords Validation, Statistical Inference, Medical Imaging Algorithms.  
  Abstract Evaluation of the performance and limitations of medical imaging algorithms is essential to estimate their impact in social, economic or clinical aspects. However, validation of medical imaging techniques is a challenging task due to the variety of imaging and clinical problems involved, as well as, the difficulties for systematically extracting a reliable solely ground truth. Although specific validation protocols are reported in any medical imaging paper, there are still two major concerns: definition of standardized methodologies transversal to all problems and generalization of conclusions to the whole clinical data set.
We claim that both issues would be fully solved if we had a statistical model relating ground truth and the output of computational imaging techniques. Such a statistical model could conclude to what extent the algorithm behaves like the ground truth from the analysis of a sampling of the validation data set. We present a statistical inference framework reporting the agreement and describing the relationship of two quantities. We show its transversality by applying it to validation of two different tasks: contour segmentation and landmark correspondence.
 
  Address Sevilla  
  Corporate Author Thesis  
  Publisher Springer-Verlag Berlin Heidelberg Place of Publication Berlin Editor (up) Pedro Real; Daniel Diaz-Pernil; Helena Molina-Abril; Ainhoa Berciano; Walter Kropatsch  
  Language Summary Language Original Title  
  Series Editor Series Title L Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CAIP  
  Notes IAM; ADAS Approved no  
  Call Number IAM @ iam @ HGR2011 Serial 1676  
Permanent link to this record
 

 
Author Josep Llados; Horst Bunke; Enric Marti edit  openurl
  Title Using cyclic string matching to find rotational and reflectional symmetric shapes Type Conference Article
  Year 1996 Publication Dagstuhl Seminar on Modelling and Planning for Sensor–based Intelligent Robot Systems Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher World Scientific Place of Publication Saarbrucken (Germany). Editor (up) R.C. Bolles, H.B.H.N.  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes DAG;IAM Approved no  
  Call Number IAM @ iam @ LBM1996 Serial 1564  
Permanent link to this record
 

 
Author C. Santa-Marta; Jaume Garcia; A. Bajo; J.J. Vaquero; M. Ledesma-Carbayo; Debora Gil edit  openurl
  Title Influence of the Temporal Resolution on the Quantification of Displacement Fields in Cardiac Magnetic Resonance Tagged Images Type Conference Article
  Year 2008 Publication XXVI Congreso Anual de la Sociedad Española de Ingenieria Biomedica Abbreviated Journal  
  Volume Issue Pages 352–353  
  Keywords  
  Abstract It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.  
  Address Valladolid  
  Corporate Author Thesis  
  Publisher Place of Publication Editor (up) Roberto hornero, Saniel Abasolo  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CASEIB  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ SGB2008 Serial 1033  
Permanent link to this record
Select All    Deselect All
 |   | 
Details

Save Citations:
Export Records: