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Author David Roche; Debora Gil; Jesus Giraldo edit   pdf
url  openurl
  Title Assessing agonist efficacy in an uncertain Em world Type Conference Article
  Year 2012 Publication 40th Keystone Symposia on mollecular and celular biology Abbreviated Journal  
  Volume Issue Pages 79  
  Keywords  
  Abstract The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
 
  Address Fairmont Banff Springs, Banff, Alberta, Canada  
  Corporate Author (down) Keystone Symposia Thesis  
  Publisher Keystone Symposia Place of Publication Editor A. Christopoulus and M. Bouvier  
  Language english Summary Language english Original Title  
  Series Editor Keystone Symposia Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference KSMCB  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGG2012 Serial 1855  
Permanent link to this record
 

 
Author Jaume Garcia; Albert Andaluz; Debora Gil; Francesc Carreras edit   pdf
url  doi
isbn  openurl
  Title Decoupled External Forces in a Predictor-Corrector Segmentation Scheme for LV Contours in Tagged MR Images Type Conference Article
  Year 2010 Publication 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Abbreviated Journal  
  Volume Issue Pages 4805-4808  
  Keywords  
  Abstract Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictorcorrector (Active Contours – Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores.  
  Address Buenos Aires (Argentina)  
  Corporate Author (down) IEEE EMB Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1557-170X ISBN 978-1-4244-4123-5 Medium  
  Area Expedition Conference EMBC  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GAG2010 Serial 1514  
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Author Debora Gil; Agnes Borras; Manuel Ballester; Francesc Carreras; Ruth Aris; Manuel Vazquez; Enric Marti; Ferran Poveda edit   pdf
url  doi
isbn  openurl
  Title MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis Type Conference Article
  Year 2011 Publication 14th International Symposium on Applied Sciences in Biomedical and Communication Technologies Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.  
  Address Barcelona; Spain  
  Corporate Author (down) Association for Computing Machinery Thesis  
  Publisher Place of Publication Barcelona, Spain Editor Association for Computing Machinery  
  Language english Summary Language english Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-1-4503-0913-4 Medium  
  Area Expedition Conference ISABEL  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GGB2011 Serial 1691  
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Author David Roche; Debora Gil; Jesus Giraldo edit   pdf
url  isbn
openurl 
  Title An inference model for analyzing termination conditions of Evolutionary Algorithms Type Conference Article
  Year 2011 Publication 14th Congrès Català en Intel·ligencia Artificial Abbreviated Journal  
  Volume Issue Pages 216-225  
  Keywords Evolutionary Computation Convergence, Termination Conditions, Statistical Inference  
  Abstract In real-world problems, it is mandatory to design a termination condition for Evolutionary Algorithms (EAs) ensuring stabilization close to the unknown optimum. Distribution-based quantities are good candidates as far as suitable parameters are used. A main limitation for application to real-world problems is that such parameters strongly depend on the topology of the objective function, as well as, the EA paradigm used.
We claim that the termination problem would be fully solved if we had a model measuring to what extent a distribution-based quantity asymptotically behaves like the solution accuracy. We present a regression-prediction model that relates any two given quantities and reports if they can be statistically swapped as termination conditions. Our framework is applied to two issues. First, exploring if the parameters involved in the computation of distribution-based quantities influence their asymptotic behavior. Second, to what extent existing distribution-based quantities can be asymptotically exchanged for the accuracy of the EA solution.
 
  Address Lleida, Catalonia (Spain)  
  Corporate Author (down) Associació Catalana Intel·ligència Artificial Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-1-60750-841-0 Medium  
  Area Expedition Conference CCIA  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGG2011a Serial 1677  
Permanent link to this record
 

 
Author Joel Barajas; Jaume Garcia; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
url  isbn
openurl 
  Title Angle Images Using Gabor Filters in Cardiac Tagged MRI Type Conference Article
  Year 2005 Publication Proceeding of the 2005 conference on Artificial Intelligence Research and Development Abbreviated Journal  
  Volume Issue Pages 107-114  
  Keywords Angle Images, Gabor Filters, Harp, Tagged Mri  
  Abstract Tagged Magnetic Resonance Imaging (MRI) is a non-invasive technique used to examine cardiac deformation in vivo. An Angle Image is a representation of a Tagged MRI which recovers the relative position of the tissue respect to the distorted tags. Thus cardiac deformation can be estimated. This paper describes a new approach to generate Angle Images using a bank of Gabor filters in short axis cardiac Tagged MRI. Our method improves the Angle Images obtained by global techniques, like HARP, with a local frequency analysis. We propose to use the phase response of a combination of a Gabor filters bank, and use it to find a more precise deformation of the left ventricle. We demonstrate the accuracy of our method over HARP by several experimental results.  
  Address Amsterdam; The Netherlands  
  Corporate Author (down) Thesis  
  Publisher IOS Press Place of Publication Amsterdam, The Netherlands Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 1-58603-560-6 Medium  
  Area Expedition Conference CAIRD  
  Notes IAM;MILAB Approved no  
  Call Number BCNPCL @ bcnpcl @ BGC2005; IAM @ iam Serial 595  
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Author Jaume Garcia; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
doi  isbn
openurl 
  Title An intuitive validation technique to compare local versus global tagged MRI analysis Type Conference Article
  Year 2005 Publication Computers In Cardiology Abbreviated Journal  
  Volume 32 Issue Pages 29–32  
  Keywords  
  Abstract Myocardium appears as a uniform tissue that seen in convectional Magnetic Resonance Images (MRI) shows just the contractile part of its movement. MR Tagging is a unique imaging technique that prints a grid over the tissue which moves according to the underlying movement of the myocardium revealing the true deformation of the cardiac muscle. Optical flow techniques based on spectral information estimate tissue displacement by analyzing information encoded in the phase maps which can be obtained using, local (Gabor) and global (HARP) methods. In this paper we compare both in synthetic and real Tagged MR sequences. We conclude that local method is slightly more accurate than the global one. On the other hand, global method is more efficient as it is much faster and less parameters have to be taken into account  
  Address Lyon (France)  
  Corporate Author (down) Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 0-7803-9337-6 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GBC2005 Serial 639  
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Author Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux edit   pdf
isbn  openurl
  Title Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function Type Conference Article
  Year 2008 Publication 8th World Congress on Computational Mechanichs (WCCM8) Abbreviated Journal  
  Volume Issue Pages  
  Keywords Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance.  
  Abstract Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.
 
  Address Venice; Italy  
  Corporate Author (down) Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 9788496736559 Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ GGV2008b Serial 993  
Permanent link to this record
 

 
Author C. Santa-Marta; Jaume Garcia; A. Bajo; J.J. Vaquero; M. Ledesma-Carbayo; Debora Gil edit  openurl
  Title Influence of the Temporal Resolution on the Quantification of Displacement Fields in Cardiac Magnetic Resonance Tagged Images Type Conference Article
  Year 2008 Publication XXVI Congreso Anual de la Sociedad Española de Ingenieria Biomedica Abbreviated Journal  
  Volume Issue Pages 352–353  
  Keywords  
  Abstract It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%.  
  Address Valladolid  
  Corporate Author (down) Thesis  
  Publisher Place of Publication Editor Roberto hornero, Saniel Abasolo  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CASEIB  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ SGB2008 Serial 1033  
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Author Joel Barajas; Jaume Garcia; Karla Lizbeth Caballero; Francesc Carreras; Sandra Pujades; Petia Radeva edit   pdf
isbn  openurl
  Title Correction of Misalignment Artifacts Among 2-D Cardiac MR Images in 3-D Space Type Conference Article
  Year 2006 Publication 1st International Wokshop on Computer Vision for Intravascular and Intracardiac Imaging (CVII’06) Abbreviated Journal  
  Volume 3217 Issue Pages 114-121  
  Keywords  
  Abstract Cardiac Magnetic Resonance images offer the opportunity to study the heart in detail. One of the main issues in its modelling is to create an accurate 3-D reconstruction of the left ventricle from 2-D views. A first step to achieve this goal is the correct registration among the different image planes due to patient movements. In this article, we present an accurate method to correct displacement artifacts using the Normalized Mutual Information. Here, the image views are treated as planes in order to diminish the approximation error caused by the association of a certain thickness, and moved simultaneously to avoid any kind of bias in the alignment process. This method has been validated using real and syntectic plane displacements, yielding promising results.  
  Address  
  Corporate Author (down) Thesis  
  Publisher Place of Publication Copenhagen (Denmark) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-540-22977-3 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ BGC2006 Serial 1485  
Permanent link to this record
 

 
Author Cristina Cañero; Petia Radeva; Oriol Pujol; Ricardo Toledo; Debora Gil; J. Saludes; Juan J. Villanueva; B. Garcia del Blanco; J. Mauri; E. Fernandez-Nofrerias; J.A. Gomez-Hospital; E. Iraculis; J. Comin; C. Quiles; F. Jara; A. Cequier; E. Esplugas edit   pdf
openurl 
  Title Optimal Stent Implantation: Three-dimensional Evaluation of the Mutual Position of Stent and Vessel via Intracoronary Ecography Type Conference Article
  Year 1999 Publication Proceedings of International Conference on Computer in Cardiology (CIC´99) Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract We present a new automatic technique to visualize and quantify the mutual position between the stent and the vessel wall by considering their three-dimensional reconstruction. Two deformable generalized cylinders adapt to the image features in all IVUS planes corresponding to the vessel wall and the stent in order to reconstruct the boundaries of the stent and the vessel in space. The image features that characterize the stent and the vessel wall are determined in terms of edge and ridge image detectors taking into account the gray level of the image pixels. We show that the 30 reconstruction by deformable cylinders is accurate and robust due to the spatial data coherence in the considered volumetric IVUS image. The main clinic utility of the stent and vessel reconstruction by deformable’ cylinders consists of its possibility to visualize and to assess the optimal stent introduction.  
  Address  
  Corporate Author (down) Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes MILAB; RV; IAM; ADAS; HuPBA Approved no  
  Call Number IAM @ iam @ CRP1999a Serial 1491  
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