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Author Debora Gil; Ruth Aris; Agnes Borras; Esmitt Ramirez; Rafael Sebastian; Mariano Vazquez edit  doi
openurl 
  Title Influence of fiber connectivity in simulations of cardiac biomechanics Type Journal Article
  Year (down) 2019 Publication International Journal of Computer Assisted Radiology and Surgery Abbreviated Journal IJCAR  
  Volume 14 Issue 1 Pages 63–72  
  Keywords Cardiac electromechanical simulations; Diffusion tensor imaging; Fiber connectivity  
  Abstract PURPOSE:
Personalized computational simulations of the heart could open up new improved approaches to diagnosis and surgery assistance systems. While it is fully recognized that myocardial fiber orientation is central for the construction of realistic computational models of cardiac electromechanics, the role of its overall architecture and connectivity remains unclear. Morphological studies show that the distribution of cardiac muscular fibers at the basal ring connects epicardium and endocardium. However, computational models simplify their distribution and disregard the basal loop. This work explores the influence in computational simulations of fiber distribution at different short-axis cuts.

METHODS:
We have used a highly parallelized computational solver to test different fiber models of ventricular muscular connectivity. We have considered two rule-based mathematical models and an own-designed method preserving basal connectivity as observed in experimental data. Simulated cardiac functional scores (rotation, torsion and longitudinal shortening) were compared to experimental healthy ranges using generalized models (rotation) and Mahalanobis distances (shortening, torsion).

RESULTS:
The probability of rotation was significantly lower for ruled-based models [95% CI (0.13, 0.20)] in comparison with experimental data [95% CI (0.23, 0.31)]. The Mahalanobis distance for experimental data was in the edge of the region enclosing 99% of the healthy population.

CONCLUSIONS:
Cardiac electromechanical simulations of the heart with fibers extracted from experimental data produce functional scores closer to healthy ranges than rule-based models disregarding architecture connectivity.
 
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  Notes IAM; 600.096; 601.323; Approved no  
  Call Number Admin @ si @ GAB2019 Serial 3133  
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Author Debora Gil; Rosa Maria Ortiz; Carles Sanchez; Antoni Rosell edit  doi
openurl 
  Title Objective endoscopic measurements of central airway stenosis. A pilot study Type Journal Article
  Year (down) 2018 Publication Respiration Abbreviated Journal RES  
  Volume 95 Issue Pages 63–69  
  Keywords Bronchoscopy; Tracheal stenosis; Airway stenosis; Computer-assisted analysis  
  Abstract Endoscopic estimation of the degree of stenosis in central airway obstruction is subjective and highly variable. Objective: To determine the benefits of using SENSA (System for Endoscopic Stenosis Assessment), an image-based computational software, for obtaining objective stenosis index (SI) measurements among a group of expert bronchoscopists and general pulmonologists. Methods: A total of 7 expert bronchoscopists and 7 general pulmonologists were enrolled to validate SENSA usage. The SI obtained by the physicians and by SENSA were compared with a reference SI to set their precision in SI computation. We used SENSA to efficiently obtain this reference SI in 11 selected cases of benign stenosis. A Web platform with three user-friendly microtasks was designed to gather the data. The users had to visually estimate the SI from videos with and without contours of the normal and the obstructed area provided by SENSA. The users were able to modify the SENSA contours to define the reference SI using morphometric bronchoscopy. Results: Visual SI estimation accuracy was associated with neither bronchoscopic experience (p = 0.71) nor the contours of the normal and the obstructed area provided by the system (p = 0.13). The precision of the SI by SENSA was 97.7% (95% CI: 92.4-103.7), which is significantly better than the precision of the SI by visual estimation (p < 0.001), with an improvement by at least 15%. Conclusion: SENSA provides objective SI measurements with a precision of up to 99.5%, which can be calculated from any bronchoscope using an affordable scalable interface. Providing normal and obstructed contours on bronchoscopic videos does not improve physicians' visual estimation of the SI.  
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  Notes IAM; 600.075; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ GOS2018 Serial 3043  
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Author Esmitt Ramirez; Carles Sanchez; Agnes Borras; Marta Diez Ferrer; Antoni Rosell; Debora Gil edit   pdf
url  openurl
  Title BronchoX: bronchoscopy exploration software for biopsy intervention planning Type Journal Article
  Year (down) 2018 Publication Healthcare Technology Letters Abbreviated Journal HTL  
  Volume 5 Issue 5 Pages 177–182  
  Keywords  
  Abstract Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.075; 601.323; 601.337; 600.145 Approved no  
  Call Number Admin @ si @ RSB2018a Serial 3132  
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Author Esmitt Ramirez; Carles Sanchez; Agnes Borras; Marta Diez Ferrer; Antoni Rosell; Debora Gil edit   pdf
url  openurl
  Title Image-Based Bronchial Anatomy Codification for Biopsy Guiding in Video Bronchoscopy Type Conference Article
  Year (down) 2018 Publication OR 2.0 Context-Aware Operating Theaters, Computer Assisted Robotic Endoscopy, Clinical Image-Based Procedures, and Skin Image Analysis Abbreviated Journal  
  Volume 11041 Issue Pages  
  Keywords Biopsy guiding; Bronchoscopy; Lung biopsy; Intervention guiding; Airway codification  
  Abstract Bronchoscopy examinations allow biopsy of pulmonary nodules with minimum risk for the patient. Even for experienced bronchoscopists, it is difficult to guide the bronchoscope to most distal lesions and obtain an accurate diagnosis. This paper presents an image-based codification of the bronchial anatomy for bronchoscopy biopsy guiding. The 3D anatomy of each patient is codified as a binary tree with nodes representing bronchial levels and edges labeled using their position on images projecting the 3D anatomy from a set of branching points. The paths from the root to leaves provide a codification of navigation routes with spatially consistent labels according to the anatomy observes in video bronchoscopy explorations. We evaluate our labeling approach as a guiding system in terms of the number of bronchial levels correctly codified, also in the number of labels-based instructions correctly supplied, using generalized mixed models and computer-generated data. Results obtained for three independent observers prove the consistency and reproducibility of our guiding system. We trust that our codification based on viewer’s projection might be used as a foundation for the navigation process in Virtual Bronchoscopy systems.  
  Address Granada; September 2018  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference MICCAIW  
  Notes IAM; 600.096; 600.075; 601.323; 600.145 Approved no  
  Call Number Admin @ si @ RSB2018b Serial 3137  
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Author Marta Diez Ferrer; Arturo Morales; Rosa Lopez Lisbona; Noelia Cubero; Cristian Tebe; Susana Padrones; Samantha Aso; Jordi Dorca; Debora Gil; Antoni Rosell edit  url
openurl 
  Title Ultrathin Bronchoscopy with and without Virtual Bronchoscopic Navigation: Influence of Segmentation on Diagnostic Yield Type Journal Article
  Year (down) 2018 Publication Respiration Abbreviated Journal RES  
  Volume 97 Issue 3 Pages 252-258  
  Keywords Lung cancer; Peripheral lung lesion; Diagnosis; Bronchoscopy; Ultrathin bronchoscopy; Virtual bronchoscopic navigation  
  Abstract Background: Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs. Objectives: We aimed to compare the diagnostic yield of VBN-guided and unguided ultrathin bronchoscopy (UTB) and explore clinical and technical factors associated with better results. We developed a diagnostic algorithm for deciding whether to use VBN to reach PPLs or choose an alternative diagnostic approach. Methods: We compared diagnostic yield between VBN-UTB (prospective cases) and unguided UTB (historical controls) and analyzed the VBN-UTB subgroup to identify clinical and technical variables that could predict the success of VBN-UTB. Results: Fifty-five cases and 110 controls were included. The overall diagnostic yield did not differ between the VBN-guided and unguided arms (47 and 40%, respectively; p = 0.354). Although the yield was slightly higher for PPLs ≤20 mm in the VBN-UTB arm, the difference was not significant (p = 0.069). No other clinical characteristics were associated with a higher yield in a subgroup analysis, but an 85% diagnostic yield was observed when segmentation was optimal and the PPL was endobronchial (vs. 30% when segmentation was suboptimal and 20% when segmentation was optimal but the PPL was extrabronchial). Conclusions: VBN-guided UTB is not superior to unguided UTB. A greater impact of VBN-guided over unguided UTB is highly dependent on both segmentation quality and an endobronchial location of the PPL. Segmentation quality should be considered before starting a procedure, when an alternative technique that may improve yield can be chosen, saving time and resources.  
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  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ DML2018 Serial 3134  
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Author Marta Diez Ferrer; Debora Gil; Cristian Tebe; Carles Sanchez edit   pdf
doi  openurl
  Title Positive Airway Pressure to Enhance Computed Tomography Imaging for Airway Segmentation for Virtual Bronchoscopic Navigation Type Journal Article
  Year (down) 2018 Publication Respiration Abbreviated Journal RES  
  Volume 96 Issue 6 Pages 525-534  
  Keywords Multidetector computed tomography; Bronchoscopy; Continuous positive airway pressure; Image enhancement; Virtual bronchoscopic navigation  
  Abstract Abstract
RATIONALE:
Virtual bronchoscopic navigation (VBN) guidance to peripheral pulmonary lesions is often limited by insufficient segmentation of the peripheral airways.

OBJECTIVES:
To test the effect of applying positive airway pressure (PAP) during CT acquisition to improve segmentation, particularly at end-expiration.

METHODS:
CT acquisitions in inspiration and expiration with 4 PAP protocols were recorded prospectively and compared to baseline inspiratory acquisitions in 20 patients. The 4 protocols explored differences between devices (flow vs. turbine), exposures (within seconds vs. 15-min) and pressure levels (10 vs. 14 cmH2O). Segmentation quality was evaluated with the number of airways and number of endpoints reached. A generalized mixed-effects model explored the estimated effect of each protocol.

MEASUREMENTS AND MAIN RESULTS:
Patient characteristics and lung function did not significantly differ between protocols. Compared to baseline inspiratory acquisitions, expiratory acquisitions after 15 min of 14 cmH2O PAP segmented 1.63-fold more airways (95% CI 1.07-2.48; p = 0.018) and reached 1.34-fold more endpoints (95% CI 1.08-1.66; p = 0.004). Inspiratory acquisitions performed immediately under 10 cmH2O PAP reached 1.20-fold (95% CI 1.09-1.33; p < 0.001) more endpoints; after 15 min the increase was 1.14-fold (95% CI 1.05-1.24; p < 0.001).

CONCLUSIONS:
CT acquisitions with PAP segment more airways and reach more endpoints than baseline inspiratory acquisitions. The improvement is particularly evident at end-expiration after 15 min of 14 cmH2O PAP. Further studies must confirm that the improvement increases diagnostic yield when using VBN to evaluate peripheral pulmonary lesions.
 
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  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ DGT2018 Serial 3135  
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Author Carles Sanchez; Antonio Esteban Lansaque; Agnes Borras; Marta Diez-Ferrer; Antoni Rosell; Debora Gil edit   pdf
openurl 
  Title Towards a Videobronchoscopy Localization System from Airway Centre Tracking Type Conference Article
  Year (down) 2017 Publication 12th International Conference on Computer Vision Theory and Applications Abbreviated Journal  
  Volume Issue Pages 352-359  
  Keywords Video-bronchoscopy; Lung cancer diagnosis; Airway lumen detection; Region tracking; Guided bronchoscopy navigation  
  Abstract Bronchoscopists use fluoroscopy to guide flexible bronchoscopy to the lesion to be biopsied without any kind of incision. Being fluoroscopy an imaging technique based on X-rays, the risk of developmental problems and cancer is increased in those subjects exposed to its application, so minimizing radiation is crucial. Alternative guiding systems such as electromagnetic navigation require specific equipment, increase the cost of the clinical procedure and still require fluoroscopy. In this paper we propose an image based guiding system based on the extraction of airway centres from intra-operative videos. Such anatomical landmarks are matched to the airway centreline extracted from a pre-planned CT to indicate the best path to the nodule. We present a
feasibility study of our navigation system using simulated bronchoscopic videos and a multi-expert validation of landmarks extraction in 3 intra-operative ultrathin explorations.
 
  Address Porto; Portugal; February 2017  
  Corporate Author Thesis  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference VISAPP  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ SEB2017 Serial 2943  
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Author Debora Gil; Aura Hernandez-Sabate; David Castells; Jordi Carrabina edit   pdf
openurl 
  Title CYBERH: Cyber-Physical Systems in Health for Personalized Assistance Type Conference Article
  Year (down) 2017 Publication International Symposium on Symbolic and Numeric Algorithms for Scientific Computing Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Assistance systems for e-Health applications have some specific requirements that demand of new methods for data gathering, analysis and modeling able to deal with SmallData:
1) systems should dynamically collect data from, both, the environment and the user to issue personalized recommendations; 2) data analysis should be able to tackle a limited number of samples prone to include non-informative data and possibly evolving in time due to changes in patient condition; 3) algorithms should run in real time with possibly limited computational resources and fluctuant internet access.
Electronic medical devices (and CyberPhysical devices in general) can enhance the process of data gathering and analysis in several ways: (i) acquiring simultaneously multiple sensors data instead of single magnitudes (ii) filtering data; (iii) providing real-time implementations condition by isolating tasks in individual processors of multiprocessors Systems-on-chip (MPSoC) platforms and (iv) combining information through sensor fusion
techniques.
Our approach focus on both aspects of the complementary role of CyberPhysical devices and analysis of SmallData in the process of personalized models building for e-Health applications. In particular, we will address the design of Cyber-Physical Systems in Health for Personalized Assistance (CyberHealth) in two specific application cases: 1) A Smart Assisted Driving System (SADs) for dynamical assessment of the driving capabilities of Mild Cognitive Impaired (MCI) people; 2) An Intelligent Operating Room (iOR) for improving the yield of bronchoscopic interventions for in-vivo lung cancer diagnosis.
 
  Address Timisoara; Rumania; September 2017  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference SYNASC  
  Notes IAM; 600.085; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GHC2017 Serial 3045  
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Author Debora Gil; Oriol Ramos Terrades; Elisa Minchole; Carles Sanchez; Noelia Cubero de Frutos; Marta Diez-Ferrer; Rosa Maria Ortiz; Antoni Rosell edit  url
openurl 
  Title Classification of Confocal Endomicroscopy Patterns for Diagnosis of Lung Cancer Type Conference Article
  Year (down) 2017 Publication 6th Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging Abbreviated Journal  
  Volume 10550 Issue Pages 151-159  
  Keywords  
  Abstract Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.

The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.

We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results.
 
  Address Quebec; Canada; September 2017  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CLIP  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GRM2017 Serial 2957  
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Author Debora Gil; Sergio Vera; Agnes Borras; Albert Andaluz; Miguel A. Gonzalez Ballester edit   pdf
doi  openurl
  Title Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities Type Journal Article
  Year (down) 2017 Publication Medical Image Analysis Abbreviated Journal MIA  
  Volume 35 Issue Pages 390-402  
  Keywords Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points  
  Abstract Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier B.V. Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.060; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GVB2017 Serial 2775  
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