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Author Debora Gil; Oriol Ramos Terrades; Elisa Minchole; Carles Sanchez; Noelia Cubero de Frutos; Marta Diez-Ferrer; Rosa Maria Ortiz; Antoni Rosell edit  url
openurl 
  Title Classification of Confocal Endomicroscopy Patterns for Diagnosis of Lung Cancer Type Conference Article
  Year 2017 Publication 6th Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging Abbreviated Journal  
  Volume 10550 Issue Pages 151-159  
  Keywords  
  Abstract Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.

The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.

We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results.
 
  Address Quebec; Canada; September 2017  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CLIP  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GRM2017 Serial 2957  
Permanent link to this record
 

 
Author Mireia Sole; Joan Blanco; Debora Gil; Gothami Fonseka; Richard Frodsham; Oliver Valero; Francesca Vidal; Zaida Sarrate edit   pdf
openurl 
  Title Is there a pattern of Chromosome territoriality along mice spermatogenesis? Type Conference Article
  Year 2017 Publication 3rd Spanish MeioNet Meeting Abstract Book Abbreviated Journal  
  Volume Issue Pages 55-56  
  Keywords  
  Abstract  
  Address Miraflores de la Sierra; Madrid; June 2017  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference MEIONET  
  Notes IAM; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ Serial 2958  
Permanent link to this record
 

 
Author Mireia Sole; Joan Blanco; Debora Gil; Gothami Fonseka; Richard Frodsham; Oliver Valero; Francesca Vidal; Zaida Sarrate edit  openurl
  Title Unraveling the enigmas of chromosome territoriality during spermatogenesis Type Conference Article
  Year 2017 Publication IX Jornada del Departament de Biologia Cel•lular, Fisiologia i Immunologia Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address UAB; Barcelona; June 2017  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ SBG2017b Serial 2959  
Permanent link to this record
 

 
Author Mireia Sole; Joan Blanco; Debora Gil; Gothami Fonseka; Richard Frodsham; Francesca Vidal; Zaida Sarrate edit   pdf
isbn  openurl
  Title Noves perspectives en l estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals Type Journal
  Year 2017 Publication Biologia de la Reproduccio Abbreviated Journal JBR  
  Volume 15 Issue Pages 73-78  
  Keywords  
  Abstract In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation.
 
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-84-697-3767-5 Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ SBG2017c Serial 2961  
Permanent link to this record
 

 
Author Mireia Sole; Joan Blanco; Debora Gil; Gothami Fonseka; Richard Frodsham; Oliver Valero; Francesca Vidal; Zaida Sarrate edit  openurl
  Title Análisis 3d de la territorialidad cromosómica en células espermatogénicas: explorando la infertilidad desde un nuevo prisma Type Journal
  Year 2017 Publication Revista Asociación para el Estudio de la Biología de la Reproducción Abbreviated Journal ASEBIR  
  Volume 22 Issue 2 Pages 105  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ SBG2017d Serial 3042  
Permanent link to this record
 

 
Author Debora Gil; Rosa Maria Ortiz; Carles Sanchez; Antoni Rosell edit  doi
openurl 
  Title Objective endoscopic measurements of central airway stenosis. A pilot study Type Journal Article
  Year 2018 Publication Respiration Abbreviated Journal RES  
  Volume 95 Issue Pages 63–69  
  Keywords Bronchoscopy; Tracheal stenosis; Airway stenosis; Computer-assisted analysis  
  Abstract Endoscopic estimation of the degree of stenosis in central airway obstruction is subjective and highly variable. Objective: To determine the benefits of using SENSA (System for Endoscopic Stenosis Assessment), an image-based computational software, for obtaining objective stenosis index (SI) measurements among a group of expert bronchoscopists and general pulmonologists. Methods: A total of 7 expert bronchoscopists and 7 general pulmonologists were enrolled to validate SENSA usage. The SI obtained by the physicians and by SENSA were compared with a reference SI to set their precision in SI computation. We used SENSA to efficiently obtain this reference SI in 11 selected cases of benign stenosis. A Web platform with three user-friendly microtasks was designed to gather the data. The users had to visually estimate the SI from videos with and without contours of the normal and the obstructed area provided by SENSA. The users were able to modify the SENSA contours to define the reference SI using morphometric bronchoscopy. Results: Visual SI estimation accuracy was associated with neither bronchoscopic experience (p = 0.71) nor the contours of the normal and the obstructed area provided by the system (p = 0.13). The precision of the SI by SENSA was 97.7% (95% CI: 92.4-103.7), which is significantly better than the precision of the SI by visual estimation (p < 0.001), with an improvement by at least 15%. Conclusion: SENSA provides objective SI measurements with a precision of up to 99.5%, which can be calculated from any bronchoscope using an affordable scalable interface. Providing normal and obstructed contours on bronchoscopic videos does not improve physicians' visual estimation of the SI.  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.075; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ GOS2018 Serial 3043  
Permanent link to this record
 

 
Author Rosa Maria Ortiz; Debora Gil; Elisa Minchole; Marta Diez-Ferrer; Noelia Cubero de Frutos edit  openurl
  Title Classification of Confolcal Endomicroscopy Patterns for Diagnosis of Lung Cancer Type Conference Article
  Year 2017 Publication 18th World Conference on Lung Cancer Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.

The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.

We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results.
 
  Address Yokohama; Japan; October 2017  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference IASLC WCLC  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ OGM2017 Serial 3044  
Permanent link to this record
 

 
Author Debora Gil; Aura Hernandez-Sabate; David Castells; Jordi Carrabina edit   pdf
openurl 
  Title CYBERH: Cyber-Physical Systems in Health for Personalized Assistance Type Conference Article
  Year 2017 Publication International Symposium on Symbolic and Numeric Algorithms for Scientific Computing Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Assistance systems for e-Health applications have some specific requirements that demand of new methods for data gathering, analysis and modeling able to deal with SmallData:
1) systems should dynamically collect data from, both, the environment and the user to issue personalized recommendations; 2) data analysis should be able to tackle a limited number of samples prone to include non-informative data and possibly evolving in time due to changes in patient condition; 3) algorithms should run in real time with possibly limited computational resources and fluctuant internet access.
Electronic medical devices (and CyberPhysical devices in general) can enhance the process of data gathering and analysis in several ways: (i) acquiring simultaneously multiple sensors data instead of single magnitudes (ii) filtering data; (iii) providing real-time implementations condition by isolating tasks in individual processors of multiprocessors Systems-on-chip (MPSoC) platforms and (iv) combining information through sensor fusion
techniques.
Our approach focus on both aspects of the complementary role of CyberPhysical devices and analysis of SmallData in the process of personalized models building for e-Health applications. In particular, we will address the design of Cyber-Physical Systems in Health for Personalized Assistance (CyberHealth) in two specific application cases: 1) A Smart Assisted Driving System (SADs) for dynamical assessment of the driving capabilities of Mild Cognitive Impaired (MCI) people; 2) An Intelligent Operating Room (iOR) for improving the yield of bronchoscopic interventions for in-vivo lung cancer diagnosis.
 
  Address Timisoara; Rumania; September 2017  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference SYNASC  
  Notes IAM; 600.085; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GHC2017 Serial 3045  
Permanent link to this record
 

 
Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso; Vanesa Vicens; Cubero Noelia; Rosa Lopez Lisbona; Carles Sanchez; Agnes Borras; Antoni Rosell edit  url
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type Journal Article
  Year 2016 Publication Chest Journal Abbreviated Journal CHEST  
  Volume 150 Issue 4 Pages 1003A  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.075 Approved no  
  Call Number Admin @ si @ DGC2016 Serial 3099  
Permanent link to this record
 

 
Author Esmitt Ramirez; Carles Sanchez; Agnes Borras; Marta Diez-Ferrer; Antoni Rosell; Debora Gil edit   pdf
url  openurl
  Title BronchoX: bronchoscopy exploration software for biopsy intervention planning Type Journal Article
  Year 2018 Publication Healthcare Technology Letters Abbreviated Journal HTL  
  Volume 5 Issue 5 Pages 177–182  
  Keywords  
  Abstract Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.  
  Address  
  Corporate Author rank (SJR) Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.075; 601.323; 601.337; 600.145 Approved no  
  Call Number Admin @ si @ RSB2018a Serial 3132  
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