| |
Records |
Links |
|
Author |
David Roche; Debora Gil; Jesus Giraldo |
|
| |
Title |
Assessing agonist efficacy in an uncertain Em world |
Type |
Conference Article |
| |
Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
79 |
|
| |
Keywords |
|
|
| |
Abstract |
The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
|
| |
Address |
Fairmont Banff Springs, Banff, Alberta, Canada |
|
| |
Corporate Author |
Keystone Symposia |
Thesis |
|
|
| |
Publisher |
Keystone Symposia |
Place of Publication |
|
Editor |
A. Christopoulus and M. Bouvier |
|
| |
Language |
english |
Summary Language |
english |
Original Title |
|
|
| |
Series Editor  |
Keystone Symposia |
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
KSMCB |
|
| |
Notes |
IAM |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ RGG2012 |
Serial |
1855 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Eric Amiel |
|
| |
Title |
Visualisation de vaisseaux sanguins |
Type |
Report |
| |
Year |
2005 |
Publication |
Rapport de Stage |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
|
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
Université Paul Sabatier Toulouse III |
Thesis |
Bachelor's thesis |
|
| |
Publisher |
Université Paul Sabatier Toulouse III |
Place of Publication |
Toulouse |
Editor |
Enric Marti |
|
| |
Language |
French |
Summary Language |
French |
Original Title |
|
|
| |
Series Editor |
IUP Systèmes Intelligents |
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ Ami2005 |
Serial |
1690 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Patricia Marquez; Debora Gil ; Aura Hernandez-Sabate |
|
| |
Title |
Error Analysis for Lucas-Kanade Based Schemes |
Type |
Conference Article |
| |
Year |
2012 |
Publication |
9th International Conference on Image Analysis and Recognition |
Abbreviated Journal |
|
|
| |
Volume |
7324 |
Issue |
I |
Pages |
184-191 |
|
| |
Keywords |
Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance |
|
| |
Abstract |
Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures. |
|
| |
Address |
Aveiro, Portugal |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer-Verlag Berlin Heidelberg |
Place of Publication |
|
Editor |
|
|
| |
Language |
english |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
Campilho, Aurélio and Kamel, Mohamed |
Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
LNCS |
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0302-9743 |
ISBN |
978-3-642-31294-6 |
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
ICIAR |
|
| |
Notes |
IAM |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ MGH2012a |
Serial |
1899 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Petia Radeva; Enric Marti |
|
| |
Title |
Facial Features Segmentation by Model-Based Snakes. |
Type |
Miscellaneous |
| |
Year |
1995 |
Publication |
Trobada de Joves Investigadors, IIIA. |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
|
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
Bellaterra (Barcelona), Spain |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
MILAB; IAM |
Approved |
no |
|
| |
Call Number |
BCNPCL @ bcnpcl @ RaM1995a |
Serial |
130 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Jaume Garcia |
|
| |
Title |
Propagacio de fronts per a la segmentacio en imatges IVUS |
Type |
Report |
| |
Year |
2002 |
Publication |
Technical Report |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
65 |
Pages |
|
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
CVC (UAB) |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ Gar2002 |
Serial |
328 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Albert Andaluz |
|
| |
Title |
LV Contour Segmentation in TMR images using Semantic Description of Tissue and Prior Knowledge Correction |
Type |
Report |
| |
Year |
2009 |
Publication |
CVC Technical Report |
Abbreviated Journal |
|
|
| |
Volume |
142 |
Issue |
|
Pages |
|
|
| |
Keywords |
Active Contour Models; Snakes; Active Shape Models; Deformable Templates; Left Ventricle Segmentation; Generalized Orthogonal Procrustes Analysis; Harmonic Phase Flow; Principal Component Analysis; Tagged Magnetic Resonance |
|
| |
Abstract |
The Diagnosis of Left Ventricle (LV) pathologies is related to regional wall motion analysis. Health indicator scores such as the rotation and the torsion are useful for the diagnose of the Left Ventricle (LV) function. However, this requires proper identification of LV segments. On one hand, manual segmentation is robust, but it is slow and requires medical expertise. On the other hand, the tag pattern in Tagged Magnetic Resonance (TMR) sequences is a problem for the automatic segmentation of the LV boundaries. Consequently, we propose a method based in the classical formulation of parametric Snakes, combined with Active Shape models. Our semantic definition of the LV is tagged tissue that experiences motion in the systolic cycle. This defines two energy potentials for the Snake convergence. Additionally, the mean shape corrects excessive deviation from the anatomical shape. We have validated our approach in 15 healthy volunteers and two short axis cuts. In this way, we have compared the automatic segmentations to manual shapes outlined by medical experts. Also, we have explored the accuracy of clinical scores computed using automatic contours. The results show minor divergence in the approximation and the manual segmentations as well as robust computation of clinical scores in all cases. From this we conclude that the proposed method is a promising support tool for clinical analysis. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
Master's thesis |
|
| |
Publisher |
|
Place of Publication |
Bellaterra 08193, Barcelona, Spain |
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM; |
Approved |
no |
|
| |
Call Number |
IAM @ iam @ And2009 |
Serial |
1667 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Oriol Rodriguez-Leon; Josefina Mauri; Eduard Fernandez-Nofrerias; M.Gomez; Antonio Tovar; L.Cano; C.Diego; Carme Julia; Vicente del Valle; Debora Gil; Petia Radeva |
|
| |
Title |
Ecografia Intracoronaria: Segmentacio Automatica de area de la llum |
Type |
Journal |
| |
Year |
2002 |
Publication |
Revista Societat Catalana de Cardiologia |
Abbreviated Journal |
|
|
| |
Volume |
4 |
Issue |
4 |
Pages |
42 |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
Barcelona |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
XIVe Congres de la Societat Catalana de Cardiologia |
|
| |
Notes |
MILAB;IAM |
Approved |
no |
|
| |
Call Number |
BCNPCL @ bcnpcl @ RMF2002 |
Serial |
435 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Debora Gil; Petia Radeva |
|
| |
Title |
A Regularized Curvature Flow Designed for a Selective Shape Restoration |
Type |
Journal Article |
| |
Year |
2004 |
Publication |
IEEE Transactions on Image Processing |
Abbreviated Journal |
|
|
| |
Volume |
13 |
Issue |
|
Pages |
1444–1458 |
|
| |
Keywords |
Geometric flows, nonlinear filtering, shape recovery. |
|
| |
Abstract |
Among all filtering techniques, those based exclu- sively on image level sets (geometric flows) have proven to be the less sensitive to the nature of noise and the most contrast preserving. A common feature to existent curvature flows is that they penalize high curvature, regardless of the curve regularity. This constitutes a major drawback since curvature extreme values are standard descriptors of the contour geometry. We argue that an operator designed with shape recovery purposes should include a term penalizing irregularity in the curvature rather than its magnitude. To this purpose, we present a novel geometric flow that includes a function that measures the degree of local irregularity present in the curve. A main advantage is that it achieves non-trivial steady states representing a smooth model of level curves in a noisy image. Performance of our approach is compared to classical filtering techniques in terms of quality in the restored image/shape and asymptotic behavior. We empirically prove that our approach is the technique that achieves the best compromise between image quality and evolution stabilization. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
IAM;MILAB |
Approved |
no |
|
| |
Call Number |
BCNPCL @ bcnpcl @ GiR2004b |
Serial |
491 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Oriol Rodriguez-Leon; Josefina Mauri;Eduard Fernandez-Nofrerias; Antonio Tovar; Vicente del Valle; Aura Hernandez-Sabate; Debora Gil; Petia Radeva |
|
| |
Title |
Utilizacion de la estructura de los campos vectoriales para la deteccion de la Adventicia en imagenes de Ecografia Intracoronaria |
Type |
Journal |
| |
Year |
2004 |
Publication |
Revista Española de Cardiología |
Abbreviated Journal |
REC |
|
| |
Volume |
57 |
Issue |
2 |
Pages |
100 |
|
| |
Keywords |
|
|
| |
Abstract |
|
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
SEC |
|
| |
Notes |
MILAB;IAM |
Approved |
no |
|
| |
Call Number |
BCNPCL @ bcnpcl @ RMF2004 |
Serial |
566 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Joel Barajas; Jaume Garcia; Francesc Carreras; Sandra Pujades; Petia Radeva |
|
| |
Title |
Angle Images Using Gabor Filters in Cardiac Tagged MRI |
Type |
Conference Article |
| |
Year |
2005 |
Publication |
Proceeding of the 2005 conference on Artificial Intelligence Research and Development |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
107-114 |
|
| |
Keywords |
Angle Images, Gabor Filters, Harp, Tagged Mri |
|
| |
Abstract |
Tagged Magnetic Resonance Imaging (MRI) is a non-invasive technique used to examine cardiac deformation in vivo. An Angle Image is a representation of a Tagged MRI which recovers the relative position of the tissue respect to the distorted tags. Thus cardiac deformation can be estimated. This paper describes a new approach to generate Angle Images using a bank of Gabor filters in short axis cardiac Tagged MRI. Our method improves the Angle Images obtained by global techniques, like HARP, with a local frequency analysis. We propose to use the phase response of a combination of a Gabor filters bank, and use it to find a more precise deformation of the left ventricle. We demonstrate the accuracy of our method over HARP by several experimental results. |
|
| |
Address |
Amsterdam; The Netherlands |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
IOS Press |
Place of Publication |
Amsterdam, The Netherlands |
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
1-58603-560-6 |
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
CAIRD |
|
| |
Notes |
IAM;MILAB |
Approved |
no |
|
| |
Call Number |
BCNPCL @ bcnpcl @ BGC2005; IAM @ iam |
Serial |
595 |
|
| Permanent link to this record |
