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Author |
Jaume Garcia |
![download PDF file pdf](http://refbase.cvc.uab.es/img/file_PDF.gif)
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Title |
Statistical Models of the Architecture and Function of the Left Ventricle |
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Book Whole |
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Year |
2009 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Cardiovascular Diseases, specially those affecting the Left Ventricle (LV), are the leading cause of death in developed countries with approximately a 30% of all global deaths. In order to address this public health concern, physicians focus on diagnosis and therapy planning. On one hand, early and accurate detection of Regional Wall Motion Abnormalities (RWMA) significantly contributes to a quick diagnosis and prevents the patient to reach more severe stages. On the other hand, a thouroughly knowledge of the normal gross anatomy of the LV, as well as, the distribution of its muscular fibers is crucial for designing specific interventions and therapies (such as pacemaker implanction). Statistical models obtained from the analysis of different imaging modalities allow the computation of the normal ranges of variation within a given population. Normality models are a valuable tool for the definition of objective criterions quantifying the degree of (anomalous) deviation of the LV function and anatomy for a given subject. The creation of statistical models involve addressing three main issues: extraction of data from images, definition of a common domain for comparison of data across patients and designing appropriate statistical analysis schemes. In this PhD thesis we present generic image processing tools for the creation of statistical models of the LV anatomy and function. On one hand, we use differential geometry concepts to define a computational framework (the Normalized Parametric Domain, NPD) suitable for the comparison and fusion of several clinical scores obtained over the LV. On the other hand, we present a variational approach (the Harmonic Phase Flow, HPF) for the estimation of myocardial motion that provides dense and continuous vector fields without overestimating motion at injured areas. These tools are used for the creation of statistical models. Regarding anatomy, we obtain an atlas jointly modelling, both, LV gross anatomy and fiber architecture. Regarding function, we compute normality patterns of scores characterizing the (global and local) LV function and explore, for the first time, the configuration of local scores better suited for RWMA detection. |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
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Editor |
Debora Gil |
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IAM @ iam @ Gar2009a |
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1499 |
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Author |
Debora Gil |
![download PDF file pdf](http://refbase.cvc.uab.es/img/file_PDF.gif)
![find record details (via OpenURL) openurl](http://refbase.cvc.uab.es/img/xref.gif)
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Title |
Geometric Differential Operators for Shape Modelling |
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Book Whole |
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2004 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Medical imaging feeds research in many computer vision and image processing fields: image filtering, segmentation, shape recovery, registration, retrieval and pattern matching. Because of their low contrast changes and large variety of artifacts and noise, medical imaging processing techniques relying on an analysis of the geometry of image level sets rather than on intensity values result in more robust treatment. From the starting point of treatment of intravascular images, this PhD thesis ad- dresses the design of differential image operators based on geometric principles for a robust shape modelling and restoration. Among all fields applying shape recovery, we approach filtering and segmentation of image objects. For a successful use in real images, the segmentation process should go through three stages: noise removing, shape modelling and shape recovery. This PhD addresses all three topics, but for the sake of algorithms as automated as possible, techniques for image processing will be designed to satisfy three main principles: a) convergence of the iterative schemes to non-trivial states avoiding image degeneration to a constant image and representing smooth models of the originals; b) smooth asymptotic behav- ior ensuring stabilization of the iterative process; c) fixed parameter values ensuring equal (domain free) performance of the algorithms whatever initial images/shapes. Our geometric approach to the generic equations that model the different processes approached enables defining techniques satisfying all the former requirements. First, we introduce a new curvature-based geometric flow for image filtering achieving a good compromise between noise removing and resemblance to original images. Sec- ond, we describe a new family of diffusion operators that restrict their scope to image level curves and serve to restore smooth closed models from unconnected sets of points. Finally, we design a regularization of snake (distance) maps that ensures its smooth convergence towards any closed shape. Experiments show that performance of the techniques proposed overpasses that of state-of-the-art algorithms. |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
Barcelona (Spain) |
Editor |
Jordi Saludes i Closa;Petia Radeva |
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84-933652-0-3 |
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IAM; |
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IAM @ iam @ GIL2004 |
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1517 |
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Author |
Aura Hernandez-Sabate |
![download PDF file pdf](http://refbase.cvc.uab.es/img/file_PDF.gif)
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Title |
Exploring Arterial Dynamics and Structures in IntraVascular Ultrasound Sequences |
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Book Whole |
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2009 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
Abbreviated Journal |
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Cardiovascular diseases are a leading cause of death in developed countries. Most of them are caused by arterial (specially coronary) diseases, mainly caused by plaque accumulation. Such pathology narrows blood flow (stenosis) and affects artery bio- mechanical elastic properties (atherosclerosis). In the last decades, IntraVascular UltraSound (IVUS) has become a usual imaging technique for the diagnosis and follow up of arterial diseases. IVUS is a catheter-based imaging technique which shows a sequence of cross sections of the artery under study. Inspection of a single image gives information about the percentage of stenosis. Meanwhile, inspection of longitudinal views provides information about artery bio-mechanical properties, which can prevent a fatal outcome of the cardiovascular disease. On one hand, dynamics of arteries (due to heart pumping among others) is a major artifact for exploring tissue bio-mechanical properties. On the other one, manual stenosis measurements require a manual tracing of vessel borders, which is a time-consuming task and might suffer from inter-observer variations. This PhD thesis proposes several image processing tools for exploring vessel dy- namics and structures. We present a physics-based model to extract, analyze and correct vessel in-plane rigid dynamics and to retrieve cardiac phase. Furthermore, we introduce a deterministic-statistical method for automatic vessel borders detection. In particular, we address adventitia layer segmentation. An accurate validation pro- tocol to ensure reliable clinical applicability of the methods is a crucial step in any proposal of an algorithm. In this thesis we take special care in designing a valida- tion protocol for each approach proposed and we contribute to the in vivo dynamics validation with a quantitative and objective score to measure the amount of motion suppressed. |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
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Editor |
Debora Gil |
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978-84-937261-6-4 |
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IAM; |
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IAM @ iam @ Her2009 |
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1543 |
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Author |
Ferran Poveda |
![find record details (via OpenURL) openurl](http://refbase.cvc.uab.es/img/xref.gif)
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Title |
Computer Graphics and Vision Techniques for the Study of the Muscular Fiber Architecture of the Myocardium |
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2013 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Editor |
Debora Gil;Enric Marti |
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IAM |
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Admin @ si @ Pov2013 |
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2417 |
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Author |
Carles Sanchez |
![find book details (via ISBN) isbn](http://refbase.cvc.uab.es/img/isbn.gif)
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Title |
Tracheal Structure Characterization using Geometric and Appearance Models for Efficient Assessment of Stenosis in Videobronchoscopy |
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2014 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Recent advances in endoscopic devices have increased their use for minimal invasive diagnostic and intervention procedures. Among all endoscopic modalities, bronchoscopy is one of the most frequent with around 261 millions of procedures per year. Although the use of bronchoscopy is spread among clinical facilities it presents some drawbacks, being the visual inspection for the assessment of anatomical measurements the most prevalent of them. In
particular, inaccuracies in the estimation of the degree of stenosis (the percentage of obstructed airway) decreases its diagnostic yield and might lead to erroneous treatments. An objective computation of tracheal stenosis in bronchoscopy videos would constitute a breakthrough for this non-invasive technique and a reduction in treatment cost.
This thesis settles the first steps towards on-line reliable extraction of anatomical information from videobronchoscopy for computation of objective measures. In particular, we focus on the computation of the degree of stenosis, which is obtained by comparing the area delimited by a healthy tracheal ring and the stenosed lumen. Reliable extraction of airway structures in interventional videobronchoscopy is a challenging task. This is mainly due to the large variety of acquisition conditions (positions and illumination), devices (different digitalizations) and in videos acquired at the operating room the unpredicted presence of surgical devices (such as probe ends). This thesis contributes to on-line stenosis assessment in several ways. We
propose a parametric strategy for the extraction of lumen and tracheal rings regions based on the characterization of their geometry and appearance that guide a deformable model. The geometric and appearance characterization is based on a physical model describing the way bronchoscopy images are obtained and includes local and global descriptions. In order to ensure a systematic applicability we present a statistical framework to select the optimal
parameters of our method. Experiments perform on the first public annotated database, show that the performance of our method is comparable to the one provided by clinicians and its computation time allows for a on-line implementation in the operating room. |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
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Editor |
F. Javier Sanchez;Debora Gil;Jorge Bernal |
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978-84-940902-9-5 |
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Notes |
IAM; 600.075 |
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no |
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Call Number |
Admin @ si @ San2014 |
Serial |
2575 |
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Author |
David Roche |
![find record details (via OpenURL) openurl](http://refbase.cvc.uab.es/img/xref.gif)
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Title |
A Statistical Framework for Terminating Evolutionary Algorithms at their Steady State |
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Book Whole |
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2015 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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As any iterative technique, it is a necessary condition a stop criterion for terminating Evolutionary Algorithms (EA). In the case of optimization methods, the algorithm should stop at the time it has reached a steady state so it can not improve results anymore. Assessing the reliability of termination conditions for EAs is of prime importance. A wrong or weak stop criterion can negatively aect both the computational eort and the nal result.
In this Thesis, we introduce a statistical framework for assessing whether a termination condition is able to stop EA at its steady state. In one hand a numeric approximation to steady states to detect the point in which EA population has lost its diversity has been presented for EA termination. This approximation has been applied to dierent EA paradigms based on diversity and a selection of functions covering the properties most relevant for EA convergence. Experiments show that our condition works regardless of the search space dimension and function landscape and Dierential Evolution (DE) arises as the best paradigm. On the other hand, we use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in xspace.
Our theoretical framework is analyzed across several benchmark test functions
and two standard termination criteria based on function improvement in f-space and EA population x-space distribution for the DE paradigm. Results validate our statistical framework as a powerful tool for determining the capability of a measure for terminating EA and select the x-space distribution as the best-suited for accurately stopping DE in real-world applications. |
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July 2015 |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
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Editor |
Debora Gil;Jesus Giraldo |
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IAM; 600.075 |
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Call Number |
Admin @ si @ Roc2015 |
Serial |
2686 |
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Permanent link to this record |
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Author |
Patricia Marquez |
![find book details (via ISBN) isbn](http://refbase.cvc.uab.es/img/isbn.gif)
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Title |
A Confidence Framework for the Assessment of Optical Flow Performance |
Type |
Book Whole |
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Year |
2015 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Optical Flow (OF) is the input of a wide range of decision support systems such as car driver assistance, UAV guiding or medical diagnose. In these real situations, the absence of ground truth forces to assess OF quality using quantities computed from either sequences or the computed optical flow itself. These quantities are generally known as Confidence Measures, CM. Even if we have a proper confidence measure we still need a way to evaluate its ability to discard pixels with an OF prone to have a large error. Current approaches only provide a descriptive evaluation of the CM performance but such approaches are not capable to fairly compare different confidence measures and optical flow algorithms. Thus, it is of prime importance to define a framework and a general road map for the evaluation of optical flow performance.
This thesis provides a framework able to decide which pairs “ optical flow – confidence measure” (OF-CM) are best suited for optical flow error bounding given a confidence level determined by a decision support system. To design this framework we cover the following points:
Descriptive scores. As a first step, we summarize and analyze the sources of inaccuracies in the output of optical flow algorithms. Second, we present several descriptive plots that visually assess CM capabilities for OF error bounding. In addition to the descriptive plots, given a plot representing OF-CM capabilities to bound the error, we provide a numeric score that categorizes the plot according to its decreasing profile, that is, a score assessing CM performance.
Statistical framework. We provide a comparison framework that assesses the best suited OF-CM pair for error bounding that uses a two stage cascade process. First of all we assess the predictive value of the confidence measures by means of a descriptive plot. Then, for a sample of descriptive plots computed over training frames, we obtain a generic curve that will be used for sequences with no ground truth. As a second step, we evaluate the obtained general curve and its capabilities to really reflect the predictive value of a confidence measure using the variability across train frames by means of ANOVA.
The presented framework has shown its potential in the application on clinical decision support systems. In particular, we have analyzed the impact of the different image artifacts such as noise and decay to the output of optical flow in a cardiac diagnose system and we have improved the navigation inside the bronchial tree on bronchoscopy. |
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July 2015 |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
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Editor |
Debora Gil;Aura Hernandez |
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978-84-943427-2-1 |
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Notes |
IAM; 600.075 |
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no |
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Call Number |
Admin @ si @ Mar2015 |
Serial |
2687 |
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Permanent link to this record |
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Author |
Sergio Vera |
![find book details (via ISBN) isbn](http://refbase.cvc.uab.es/img/isbn.gif)
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Title |
Anatomic Registration based on Medial Axis Parametrizations |
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Book Whole |
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2015 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
Abbreviated Journal |
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Image registration has been for many years the gold standard method to bring two images into correspondence. It has been used extensively in the eld of medical imaging in order to put images of dierent patients into a common overlapping spatial position. However, medical image registration is a slow, iterative optimization process, where many variables and prone to fall into the pit traps local minima.
A coordinate system parameterizing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specic anatomical sites, parameterizations ensure integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric meshes over the surface of anatomical shapes, given their ability to set values at specic locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at discrete sites of limited geometric diversity.
The medial surface of the shape can be used to provide a continuous basis for the denition of a depth coordinate. However, given that dierent methods for generation of medial surfaces generate dierent manifolds, not all of them are equally suited to be the basis of radial coordinate for a parameterization. It would be desirable that the medial surface will be smooth, and robust to surface shape noise, with low number of spurious branches or surfaces.
In this thesis we present methods for computation of smooth medial manifolds and apply them to the generation of for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the volume medial surface. This reference system sets a solid base for creating anatomical models of the anatomical shapes, and allows comparing several patients in a common framework of reference. |
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November 2015 |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
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Editor |
Debora Gil;Miguel Angel Gonzalez Ballester |
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978-84-943427-8-3 |
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IAM; 600.075 |
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no |
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Call Number |
Admin @ si @ Ver2015 |
Serial |
2708 |
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Permanent link to this record |
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Author |
Antonio Esteban Lansaque |
![find book details (via ISBN) isbn](http://refbase.cvc.uab.es/img/isbn.gif)
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Title |
An Endoscopic Navigation System for Lung Cancer Biopsy |
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Book Whole |
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2019 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Lung cancer is one of the most diagnosed cancers among men and women. Actually,
lung cancer accounts for 13% of the total cases with a 5-year global survival
rate in patients. Although Early detection increases survival rate from 38% to 67%, accurate diagnosis remains a challenge. Pathological confirmation requires extracting a sample of the lesion tissue for its biopsy. The preferred procedure for tissue biopsy is called bronchoscopy. A bronchoscopy is an endoscopic technique for the internal exploration of airways which facilitates the performance of minimal invasive interventions with low risk for the patient. Recent advances in bronchoscopic devices have increased their use for minimal invasive diagnostic and intervention procedures, like lung cancer biopsy sampling. Despite the improvement in bronchoscopic device quality, there is a lack of intelligent computational systems for supporting in-vivo clinical decision during examinations. Existing technologies fail to accurately reach the lesion due to several aspects at intervention off-line planning and poor intra-operative guidance at exploration time. Existing guiding systems radiate patients and clinical staff,might be expensive and achieve a suboptimlal 70% of yield boost. Diagnostic yield could be improved reducing radiation and costs by developing intra-operative support systems able to guide the bronchoscopist to the lesion during the intervention. The goal of this PhD thesis is to develop an image-based navigation systemfor intra-operative guidance of bronchoscopists to a target lesion across a path previously planned on a CT-scan. We propose a 3D navigation system which uses the anatomy of video bronchoscopy frames to locate the bronchoscope within the airways. Once the bronchoscope is located, our navigation system is able to indicate the bifurcation which needs to be followed to reach the lesion. In order to facilitate an off-line validation
as realistic as possible, we also present a method for augmenting simulated virtual bronchoscopies with the appearance of intra-operative videos. Experiments performed on augmented and intra-operative videos, prove that our algorithm can be speeded up for an on-line implementation in the operating room. |
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October 2019 |
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Thesis ![sorted by Thesis field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
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Editor |
Debora Gil;Carles Sanchez |
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978-84-121011-0-2 |
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Notes |
IAM; 600.139; 600.145 |
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no |
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Call Number |
Admin @ si @ Est2019 |
Serial |
3392 |
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Author |
Jose Elias Yauri |
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Title |
Deep Learning Based Data Fusion Approaches for the Assessment of Cognitive States on EEG Signals |
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Book Whole |
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2023 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
Abbreviated Journal |
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Abstract |
For millennia, the study of the couple brain-mind has fascinated the humanity in order to understand the complex nature of cognitive states. A cognitive state is the state of the mind at a specific time and involves cognition activities to acquire and process information for making a decision, solving a problem, or achieving a goal.
While normal cognitive states assist in the successful accomplishment of tasks; on the contrary, abnormal states of the mind can lead to task failures due to a reduced cognition capability. In this thesis, we focus on the assessment of cognitive states by means of the analysis of ElectroEncephaloGrams (EEG) signals using deep learning methods. EEG records the electrical activity of the brain using a set of electrodes placed on the scalp that output a set of spatiotemporal signals that are expected to be correlated to a specific mental process.
From the point of view of artificial intelligence, any method for the assessment of cognitive states using EEG signals as input should face several challenges. On the one hand, one should determine which is the most suitable approach for the optimal combination of the multiple signals recorded by EEG electrodes. On the other hand, one should have a protocol for the collection of good quality unambiguous annotated data, and an experimental design for the assessment of the generalization and transfer of models. In order to tackle them, first, we propose several convolutional neural architectures to perform data fusion of the signals recorded by EEG electrodes, at raw signal and feature levels. Four channel fusion methods, easy to incorporate into any neural network architecture, are proposed and assessed. Second, we present a method to create an unambiguous dataset for the prediction of cognitive mental workload using serious games and an Airbus-320 flight simulator. Third, we present a validation protocol that takes into account the levels of generalization of models based on the source and amount of test data.
Finally, the approaches for the assessment of cognitive states are applied to two use cases of high social impact: the assessment of mental workload for personalized support systems in the cockpit and the detection of epileptic seizures. The results obtained from the first use case show the feasibility of task transfer of models trained to detect workload in serious games to real flight scenarios. The results from the second use case show the generalization capability of our EEG channel fusion methods at k-fold cross-validation, patient-specific, and population levels. |
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Ph.D. thesis |
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IMPRIMA |
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Aura Hernandez;Debora Gil |
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no |
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Admin @ si @ Yau2023 |
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3962 |
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