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Author |
Debora Gil; Agnes Borras; Manuel Ballester; Francesc Carreras; Ruth Aris; Manuel Vazquez; Enric Marti; Ferran Poveda |
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Title |
MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis |
Type |
Conference Article |
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Year |
2011 |
Publication |
14th International Symposium on Applied Sciences in Biomedical and Communication Technologies |
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Abstract |
Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization. |
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Address |
Barcelona; Spain |
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Corporate Author |
Association for Computing Machinery |
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Place of Publication |
Barcelona, Spain |
Editor |
Association for Computing Machinery |
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Language |
english |
Summary Language  |
english |
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ISBN |
978-1-4503-0913-4 |
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Conference |
ISABEL |
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IAM |
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Call Number |
IAM @ iam @ GGB2011 |
Serial |
1691 |
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Author |
Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru; Miguel Angel Gonzalez Ballester |
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Title |
Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Workshop on Computational and Clinical Applications in Abdominal Imaging |
Abbreviated Journal |
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Volume |
7029 |
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Pages |
223–230 |
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Keywords |
medial manifolds, abdomen. |
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Abstract |
Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations. |
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Address |
Toronto; Canada; |
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Springer Link |
Place of Publication |
Berlin |
Editor |
H. Yoshida et al |
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Language |
English |
Summary Language |
English |
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Series Title |
Lecture Notes in Computer Science |
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LNCS |
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ISSN |
0302-9743 |
ISBN |
978-3-642-28556-1 |
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Conference |
ABDI |
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Notes |
IAM;MV |
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no |
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Call Number |
IAM @ iam @ VGB2012 |
Serial |
1834 |
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Author |
Sergio Vera; Debora Gil; Antonio Lopez; Miguel Angel Gonzalez Ballester |
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Title |
Multilocal Creaseness Measure |
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Journal |
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Year |
2012 |
Publication |
The Insight Journal |
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IJ |
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Keywords |
Ridges, Valley, Creaseness, Structure Tensor, Skeleton, |
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Abstract |
This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission. |
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Corporate Author |
Alma IT Systems |
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Language |
english |
Summary Language |
english |
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Notes |
IAM;ADAS; |
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no |
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Call Number |
IAM @ iam @ VGL2012 |
Serial |
1840 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Assessing agonist efficacy in an uncertain Em world |
Type |
Conference Article |
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Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
Abbreviated Journal |
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Issue |
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Pages |
79 |
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Abstract |
The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
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Address |
Fairmont Banff Springs, Banff, Alberta, Canada |
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Corporate Author |
Keystone Symposia |
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Publisher |
Keystone Symposia |
Place of Publication |
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Editor |
A. Christopoulus and M. Bouvier |
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Language |
english |
Summary Language |
english |
Original Title |
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Series Editor |
Keystone Symposia |
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KSMCB |
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Notes |
IAM |
Approved |
no |
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Call Number |
IAM @ iam @ RGG2012 |
Serial |
1855 |
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