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Ferran Poveda, Debora Gil, & Enric Marti. (2012). "Multi-resolution DT-MRI cardiac tractography " In Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges (Vol. 7746, pp. 270–277). Springer Berlin Heidelberg.
Abstract: Even using objective measures from DT-MRI no consensus about myocardial architecture has been achieved so far. Streamlining provides good reconstructions at low level of detail, but falls short to give global abstract interpretations. In this paper, we present a multi-resolution methodology that is able to produce simplified representations of cardiac architecture. Our approach produces a reduced set of tracts that are representative of the main geometric features of myocardial anatomical structure. Experiments show that fiber geometry is preserved along reductions, which validates the simplified model for interpretation of cardiac architecture.
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Debora Gil, Agnes Borras, Ruth Aris, Mariano Vazquez, Pierre Lafortune, & Guillame Houzeaux. (2012). "What a difference in biomechanics cardiac fiber makes " In Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges (Vol. 7746, pp. 253–260). Springer Berlin Heidelberg.
Abstract: Computational simulations of the heart are a powerful tool for a comprehensive understanding of cardiac function and its intrinsic relationship with its muscular architecture. Cardiac biomechanical models require a vector field representing the orientation of cardiac fibers. A wrong orientation of the fibers can lead to a
non-realistic simulation of the heart functionality. In this paper we explore the impact of the fiber information on the simulated biomechanics of cardiac muscular anatomy. We have used the John Hopkins database to perform a biomechanical simulation using both a synthetic benchmark fiber distribution and the data obtained experimentally from DTI. Results illustrate how differences in fiber orientation affect heart deformation along cardiac cycle.
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Sergio Vera, Miguel Angel Gonzalez Ballester, & Debora Gil. (2012). "A medial map capturing the essential geometry of organs " In ISBI Workshop on Open Source Medical Image Analysis software (1691 - 1694). IEEE.
Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Accurate computation of one pixel wide medial surfaces is mandatory. Those surfaces must represent faithfully the geometry of the volume. Although morphological methods produce excellent results in 2D, their complexity and quality drops across dimensions, due to a more complex description of pixel neighborhoods. This paper introduces a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. Our experiments show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume
Keywords: Medial Surface Representation, Volume Reconstruction,Geometry , Image reconstruction , Liver , Manifolds , Shape , Surface morphology , Surface reconstruction
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Guillermo Torres, Jan Rodríguez Dueñas, Sonia Baeza, Antoni Rosell, Carles Sanchez, & Debora Gil. (2023). "Prediction of Malignancy in Lung Cancer using several strategies for the fusion of Multi-Channel Pyradiomics Images " In 7th Workshop on Digital Image Processing for Medical and Automotive Industry in the framework of SYNASC 2023.
Abstract: This study shows the generation process and the subsequent study of the representation space obtained by extracting GLCM texture features from computer-aided tomography (CT) scans of pulmonary nodules (PN). For this, data from 92 patients from the Germans Trias i Pujol University Hospital were used. The workflow focuses on feature extraction using Pyradiomics and the VGG16 Convolutional Neural Network (CNN). The aim of the study is to assess whether the data obtained have a positive impact on the diagnosis of lung cancer (LC). To design a machine learning (ML) model training method that allows generalization, we train SVM and neural network (NN) models, evaluating diagnosis performance using metrics defined at slice and nodule level.
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Guillermo Torres, Debora Gil, Antoni Rosell, S. Mena, & Carles Sanchez. (2023)." Virtual Radiomics Biopsy for the Histological Diagnosis of Pulmonary Nodules" In 37th International Congress and Exhibition is organized by Computer Assisted Radiology and Surgery.
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Sonia Baeza, Debora Gil, Carles Sanchez, Guillermo Torres, Ignasi Garcia Olive, Ignasi Guasch, et al. (2023)." Biopsia virtual radiomica para el diagnóstico histológico de nódulos pulmonares – Resultados intermedios del proyecto Radiolung" In SEPAR.
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Debora Gil, Guillermo Torres, & Carles Sanchez. (2023)." Transforming radiomic features into radiological words" In IEEE International Symposium on Biomedical Imaging.
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Pau Cano, Debora Gil, & Eva Musulen. (2023)." Towards automatic detection of helicobacter pylori in histological samples of gastric tissue" In IEEE International Symposium on Biomedical Imaging.
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Guillermo Torres, Debora Gil, Antonio Rosell, Sonia Baeza, & Carles Sanchez. (2023)." A radiomic biopsy for virtual histology of pulmonary nodules" In IEEE International Symposium on Biomedical Imaging.
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Debora Gil, Jaume Garcia, Mariano Vazquez, Ruth Aris, & Guilleaume Houzeaux. (2008). "Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function " In 8th World Congress on Computational Mechanichs (WCCM8).
Abstract: Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model.
Keywords: Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance.
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