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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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Journal Article |
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Year |
2013 |
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Drug Discovery Today |
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DDT |
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18 |
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7-8 |
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365-371 |
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The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
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2190 |
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Author |
Ferran Poveda; Debora Gil; Enric Marti; Albert Andaluz; Manel Ballester;Francesc Carreras Costa |
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Title |
Helical structure of the cardiac ventricular anatomy assessed by Diffusion Tensor Magnetic Resonance Imaging multi-resolution tractography |
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Journal Article |
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Year |
2013 |
Publication |
Revista Española de Cardiología |
Abbreviated Journal |
REC |
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Volume |
66 |
Issue |
10 |
Pages |
782-790 |
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Heart;Diffusion magnetic resonance imaging;Diffusion tractography;Helical heart;Myocardial ventricular band. |
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Deep understanding of myocardial structure linking morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen in this knowledge through advanced computer graphic representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging (DT-MRI).
We performed automatic tractography reconstruction of unsegmented DT-MRI canine heart datasets coming from the public database of the Johns Hopkins University. Full scale tractographies have been build with 200 seeds and are composed by streamlines computed on the vectorial field of primary eigenvectors given at the diffusion tensor volumes. Also, we introduced a novel multi-scale visualization technique in order to obtain a simplified tractography. This methodology allowed to keep the main geometric features of the fiber tracts, making easier to decipher the main properties of the architectural organization of the heart.
On the analysis of the output from our tractographic representations we found exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array.
Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3D levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by Torrent-Guasp. |
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Elsevier |
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IAM; 600.044; 600.060 |
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IAM @ iam @ PGM2013 |
Serial |
2194 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models |
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Journal Article |
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Year |
2013 |
Publication |
British Journal of Pharmacology |
Abbreviated Journal |
BJP |
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169 |
Issue |
6 |
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1189-202 |
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Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism. |
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IAM; 600.044; 605.203 |
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IAM @ iam @ RGG2013b |
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2195 |
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Author |
Joan M. Nuñez; Debora Gil; Fernando Vilariño |
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Title |
Finger joint characterization from X-ray images for rheymatoid arthritis assessment |
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Conference Article |
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Year |
2013 |
Publication |
6th International Conference on Biomedical Electronics and Devices |
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288-292 |
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Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde |
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In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection. |
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Barcelona; February 2013 |
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SciTePress |
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800 |
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BIODEVICES |
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IAM;MV; 600.057; 600.054;SIAI |
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Call Number |
IAM @ iam @ NGV2013 |
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2196 |
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Author |
Patricia Marquez; Debora Gil; R.Mester; Aura Hernandez-Sabate |
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Title |
Local Analysis of Confidence Measures for Optical Flow Quality Evaluation |
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Conference Article |
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Year |
2014 |
Publication |
9th International Conference on Computer Vision Theory and Applications |
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3 |
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450-457 |
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Optical Flow; Confidence Measure; Performance Evaluation. |
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Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance. |
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Lisboa; January 2014 |
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IAM; ADAS; 600.044; 600.060; 600.057; 601.145; 600.076; 600.075 |
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Admin @ si @ MGM2014 |
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2432 |
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Author |
Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester |
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Title |
Anatomical parameterization for volumetric meshing of the liver |
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Conference Article |
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2014 |
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SPIE – Medical Imaging |
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9036 |
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Coordinate System; Anatomy Modeling; Parameterization |
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A coordinate system describing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specific anatomical landmarks, the coordinate system allows integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric coordinate systems over the surface of anatomical shapes, given their flexibility to set values
at specific locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at sites
of limited geometric diversity. In this paper we present a method for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the
volume medial surface. We have applied the methodology to define a common reference system for the liver shape and functional anatomy. This reference system sets a solid base for creating anatomical models of the patient’s liver, and allows comparing livers from several patients in a common framework of reference. |
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Amsterdam; September 2014 |
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SPIE-MI |
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IAM; 600.075 |
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Admin @ si @ VGG2014 |
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2456 |
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Author |
Enric Marti; Antoni Gurgui; Debora Gil; Aura Hernandez-Sabate; Jaume Rocarias; Ferran Poveda |
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Title |
ABP on line: Seguimiento, estregas y evaluación en aprendizaje basado en proyectos |
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Miscellaneous |
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2014 |
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8th International Congress on University Teaching and Innovation |
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Tarragona; juliol 2014 |
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CIDUI |
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IAM; ADAS; 600.076; 600.063; 600.075 |
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Admin @ si @ MGG2014 |
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2457 |
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Author |
Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; Jaume Rocarias; Debora Gil |
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Title |
Evaluación automática de prácticas en Moodle para el aprendizaje autónomo en Ingenierías |
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2014 |
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8th International Congress on University Teaching and Innovation |
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Tarragona; juliol 2014 |
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IAM; 600.075;DAG |
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Admin @ si @ SRM2014 |
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2458 |
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Enric Marti; J.Roncaries; Debora Gil; Aura Hernandez-Sabate; Antoni Gurgui; Ferran Poveda |
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Title |
PBL On Line: A proposal for the organization, part-time monitoring and assessment of PBL group activities |
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2015 |
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Journal of Technology and Science Education |
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JOTSE |
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5 |
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2 |
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87-96 |
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IAM; ADAS; 600.076; 600.075 |
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Admin @ si @ MRG2015 |
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2608 |
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Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; J.Roncaries; Debora Gil |
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Title |
Automatic evaluation of practices in Moodle for Self Learning in Engineering |
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2015 |
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Journal of Technology and Science Education |
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JOTSE |
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5 |
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2 |
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97-106 |
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IAM; DAG; 600.075; 600.077 |
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Admin @ si @ SRM2015 |
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2610 |
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