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Author |
Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux |
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Title |
Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function |
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Conference Article |
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Year |
2008 |
Publication |
8th World Congress on Computational Mechanichs (WCCM8) |
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Keywords |
Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance. |
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Abstract |
Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model. |
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Venice; Italy |
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9788496736559 |
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IAM; |
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Call Number |
IAM @ iam @ GGV2008b |
Serial |
993 |
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Author |
Carles Sanchez; Debora Gil; Antoni Rosell; Albert Andaluz; F. Javier Sanchez |
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Title |
Segmentation of Tracheal Rings in Videobronchoscopy combining Geometry and Appearance |
Type |
Conference Article |
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Year |
2013 |
Publication |
Proceedings of the International Conference on Computer Vision Theory and Applications |
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Volume |
1 |
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Pages |
153--161 |
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Keywords |
Video-bronchoscopy, tracheal ring segmentation, trachea geometric and appearance model |
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Abstract |
Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways and minimal invasive interventions. Tracheal procedures are ordinary interventions that require measurement of the percentage of obstructed pathway for injury (stenosis) assessment. Visual assessment of stenosis in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error. Accurate detection of tracheal rings is the basis for automated estimation of the size of stenosed trachea. Processing of videobronchoscopic images acquired at the operating room is a challenging task due to the wide range of artifacts and acquisition conditions. We present a model of the geometric-appearance of tracheal rings for its detection in videobronchoscopic videos. Experiments on sequences acquired at the operating room, show a performance close to inter-observer variability |
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Barcelona; February 2013 |
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SciTePress |
Place of Publication |
Portugal |
Editor |
Sebastiano Battiato and José Braz |
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LNCS |
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978-989-8565-47-1 |
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800 |
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VISAPP |
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IAM;MV; 600.044; 600.047; 600.060; 605.203 |
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Call Number |
IAM @ iam @ SGR2013 |
Serial |
2123 |
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Author |
Antoni Gurgui; Debora Gil; Enric Marti |
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Title |
Laplacian Unitary Domain for Texture Morphing |
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Conference Article |
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Year |
2015 |
Publication |
Proceedings of the 10th International Conference on Computer Vision Theory and Applications VISIGRAPP2015 |
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1 |
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Pages |
693-699 |
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Keywords |
Facial; metamorphosis;LaplacianMorphing |
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Abstract |
Deformation of expressive textures is the gateway to realistic computer synthesis of expressions. By their good mathematical properties and flexible formulation on irregular meshes, most texture mappings rely on solutions to the Laplacian in the cartesian space. In the context of facial expression morphing, this approximation can be seen from the opposite point of view by neglecting the metric. In this paper, we use the properties of the Laplacian in manifolds to present a novel approach to warping expressive facial images in order to generate a morphing between them. |
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Munich; Germany; February 2015 |
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SciTePress |
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978-989-758-089-5 |
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VISAPP |
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IAM; 600.075 |
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Call Number |
Admin @ si @ GGM2015 |
Serial |
2614 |
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Author |
Aura Hernandez-Sabate; Debora Gil |
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Title |
The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Intravascular Ultrasound |
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Pages |
185-206 |
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Intech |
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Editor |
Yasuhiro Honda |
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Language |
English |
Summary Language |
english |
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978-953-307-900-4 |
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IAM; ADAS |
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Call Number |
IAM @ iam @ HeG2012 |
Serial |
1684 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
Type |
Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
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Volume |
796 |
Issue |
3 |
Pages |
159-181 |
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Keywords |
β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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ISSN |
0065-2598 |
ISBN |
978-94-007-7422-3 |
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IAM; 600.075 |
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Call Number |
IAM @ iam @ RGG2014 |
Serial |
2197 |
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Author |
Debora Gil; Jordi Gonzalez; Gemma Sanchez (eds) |
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Title |
Computer Vision: Advances in Research and Development |
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Book Whole |
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Year |
2007 |
Publication |
Proceedings of the 2nd CVC International Workshop |
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UAB |
Place of Publication |
Bellaterra (Spain) |
Editor |
Debora Gil; Jordi Gonzalez; Gemma Sanchez |
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2 |
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978-84-935251-4-9 |
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IAM; ISE; DAG |
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Call Number |
IAM @ iam @ GGS2007 |
Serial |
1493 |
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Author |
Mireia Sole; Joan Blanco; Debora Gil; G. Fonseka; Richard Frodsham; Francesca Vidal; Zaida Sarrate |
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Title |
Noves perspectives en l estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals |
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Journal |
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Year |
2017 |
Publication |
Biologia de la Reproduccio |
Abbreviated Journal |
JBR |
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Volume |
15 |
Issue |
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Pages |
73-78 |
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Abstract |
In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation. |
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978-84-697-3767-5 |
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IAM; 600.096; 600.145 |
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Admin @ si @ SBG2017c |
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2961 |
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Author |
Enric Marti; Ferran Poveda; Antoni Gurgui; Debora Gil |
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Title |
Aprendizaje Basado en Proyectos en Ingeniería Informática. Resultados y reflexiones de seis años de experiencia |
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Miscellaneous |
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Year |
2011 |
Publication |
Actas del Simposio-Taller JENUI 2011 |
Abbreviated Journal |
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1-8 |
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Abstract |
In this workshop a 6 years experience in Project Based Learning (PBL) in Computer Graphics, Computer Engineering course at the Autonomous University of Barcelona (UAB) is presented. We use a Moodle environment suited to manage the documentation generated in PBL. The course is organized by means of two alternative routes: a classic itinerary of lectures and test-based evaluation and another with PBL. In the PBL itinerary we explain the organization in teamgroups, homework tutoring and monitoring and evaluation guidelines for students. We provide some of the work done by students, and the results of assessment surveys carried out to students during these years. We report the evolution of our PBL itinerary in terms of, both, organization and student surveys.
The workshop aims at discussing about on the advantages and disadvantages of using these active methodologies in technical degrees such as computer engineering, in order to debate about the most suitable way of organizing PBL and assessing students learning rate. |
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Sevilla, Spain |
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spanish |
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978-84-694-5440-4 |
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JENUI |
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IAM |
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Call Number |
IAM @ iam @ MPG2011 |
Serial |
1584 |
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Author |
Enric Marti; Jaume Rocarias; Debora Gil; Marc Vivet; Carme Julia |
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Title |
Uso de recursos virtuales en Aprendizaje Basado en Proyectos. Una experiencia en la asignatura de Graficos por Computador |
Type |
Miscellaneous |
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Year |
2008 |
Publication |
Octava Jornada sobre Aprendizaje Cooperativo |
Abbreviated Journal |
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Volume |
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Pages |
79–88 |
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Abstract |
En esta comunicación presentamos una experiencia en Aprendizaje Basado en Proyectos (Project
Based Learning – PBL) realizada los últimos cuatro años (cursos del 2004-05 al 2007-08) en Gráficos
por Computador 2, asignatura optativa de tercer curso de Ingeniería Informática, titulación impartida
en la Escuela Técnica Superior de Ingeniería (ETSE) de la Universidad Autónoma de Barcelona
(UAB).
Fruto de la constante voluntad de mejora de la organización ABP de nuestra asignatura nos decidimos
a utilizar una herramienta LMS (Learning Management System) basada en Moodle y adaptada por
nosotros llamada Caronte para poder gestionar la documentación generada en ABP, y añadir una
componente semipresencial a la asignatura.
En primer lugar se presenta la organización de nuestra asignatura, basada proponer al alumno dos
itinerarios para cursarla: el itinerario ABP y el itinerario basado en clases magistrales i examen que
llamaremos TPPE (Teoría, Problemas, Prácticas, Examen). La dinámica ABP nos genera una cantidad
importante de documentación entre los grupos y el profesor, aparte de el feedback que el profesor
genera a los alumnos.
En la segunda parte del artículo presentamos los espacios docentes electrónicos de ambos itinerarios,
con los que trabajan los alumnos.
Finalmente, mostramos los resultados obtenidos de alumnos matriculados y de encuestas de valoración
realizados por los alumnos para finalmente exponer las conclusiones de estos cuatro años de
experiencia en ABP y en el uso de recursos virtuales en ABP, así como plantear mejoras y temas de
discusión sobre ABP. |
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Lleida |
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ISBN |
978-84-691-4605-7 |
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Notes |
IAM;ADAS; |
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Call Number |
IAM @ iam @ MRG2008a |
Serial |
1101 |
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Author |
Enric Marti; Debora Gil; Carme Julia |
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Title |
Experiencia d aplicació de la metodología d aprenentatge per proyectes en assignatures d Enginyeria Informàtica per a una millor adaptació als crèdits ECTS i EEES |
Type |
Miscellaneous |
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Year |
2008 |
Publication |
Experiències docents innovadores de la UAB en ciències experimentals i tecnologies i en ciències de la salud |
Abbreviated Journal |
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1 |
Issue |
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57-68 |
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UAB |
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Editor |
IDES-UAB; M.Enric Martinez, E.A. |
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ISBN |
978-84-490-2576-1 |
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IAM;ADAS; |
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no |
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Call Number |
IAM @ iam @ MGJ2008 |
Serial |
1592 |
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