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Sonia Baeza, R.Domingo, M.Salcedo, G.Moragas, J.Deportos, I.Garcia Olive, et al. (2021). Artificial Intelligence to Optimize Pulmonary Embolism Diagnosis During Covid-19 Pandemic by Perfusion SPECT/CT, a Pilot Study . American Journal of Respiratory and Critical Care Medicine, .
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Sonia Baeza, Debora Gil, I.Garcia Olive, M.Salcedo, J.Deportos, Carles Sanchez, et al. (2022). "A novel intelligent radiomic analysis of perfusion SPECT/CT images to optimize pulmonary embolism diagnosis in COVID-19 patients " . EJNMMI Physics, 9(1, Article 84), 1–17.
Abstract: Background: COVID-19 infection, especially in cases with pneumonia, is associated with a high rate of pulmonary embolism (PE). In patients with contraindications for CT pulmonary angiography (CTPA) or non-diagnostic CTPA, perfusion single-photon emission computed tomography/computed tomography (Q-SPECT/CT) is a diagnostic alternative. The goal of this study is to develop a radiomic diagnostic system to detect PE based only on the analysis of Q-SPECT/CT scans.
Methods: This radiomic diagnostic system is based on a local analysis of Q-SPECT/CT volumes that includes both CT and Q-SPECT values for each volume point. We present a combined approach that uses radiomic features extracted from each scan as input into a fully connected classifcation neural network that optimizes a weighted crossentropy loss trained to discriminate between three diferent types of image patterns (pixel sample level): healthy lungs (control group), PE and pneumonia. Four types of models using diferent confguration of parameters were tested.
Results: The proposed radiomic diagnostic system was trained on 20 patients (4,927 sets of samples of three types of image patterns) and validated in a group of 39 patients (4,410 sets of samples of three types of image patterns). In the training group, COVID-19 infection corresponded to 45% of the cases and 51.28% in the test group. In the test group, the best model for determining diferent types of image patterns with PE presented a sensitivity, specifcity, positive predictive value and negative predictive value of 75.1%, 98.2%, 88.9% and 95.4%, respectively. The best model for detecting
pneumonia presented a sensitivity, specifcity, positive predictive value and negative predictive value of 94.1%, 93.6%, 85.2% and 97.6%, respectively. The area under the curve (AUC) was 0.92 for PE and 0.91 for pneumonia. When the results obtained at the pixel sample level are aggregated into regions of interest, the sensitivity of the PE increases to 85%, and all metrics improve for pneumonia.
Conclusion: This radiomic diagnostic system was able to identify the diferent lung imaging patterns and is a frst step toward a comprehensive intelligent radiomic system to optimize the diagnosis of PE by Q-SPECT/CT.
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Sergio Vera, Debora Gil, Antonio Lopez, & Miguel Angel Gonzalez Ballester. (2012). "Multilocal Creaseness Measure " . The Insight Journal, .
Abstract: This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.
Keywords: Ridges, Valley, Creaseness, Structure Tensor, Skeleton,
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Sergio Vera, Debora Gil, Agnes Borras, Marius George Linguraru, & Miguel Angel Gonzalez Ballester. (2013). "Geometric Steerable Medial Maps " . Machine Vision and Applications, 24(6), 1255–1266.
Abstract: In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions.
This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume.
Keywords: Medial Representations ,Medial Manifolds Comparation , Surface , Reconstruction
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Oriol Rodriguez-Leor, J. Mauri, Eduard Fernandez-Nofrerias, M. Gomez, Antonio Tovar, L. Cano, et al. (2002)." Ecografia Intracoronaria: Segmentacio Automatica de area de la llum" . Revista Societat Catalana de Cardiologia, 4(4), 42.
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Oriol Rodriguez-Leor, J. Mauri, Eduard Fernandez-Nofrerias, C. Garcia, R. Villuendas, Vicente del Valle, et al. (2003)." Reconstruction of a spatio-temporal model of the intima layer from intravascular ultrasound sequences" . European Heart Journal, .
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Oriol Rodriguez-Leor, J. Mauri, Eduard Fernandez-Nofrerias, Antonio Tovar, Vicente del Valle, Aura Hernandez-Sabate, et al. (2004)." Utilizacion de la estructura de los campos vectoriales para la deteccion de la Adventicia en imagenes de Ecografia Intracoronaria" . Revista Española de Cardiología, 57(2), 100.
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Oriol Rodriguez-Leor, J. Mauri, Eduard Fernandez-Nofrerias, Antonio Tovar, Vicente del Valle, Aura Hernandez-Sabate, et al. (2004)." Utilización de la Estructura de los Campos Vectoriales para la Detección de la Adventicia en Imágenes de Ecografía Intracoronaria" . Revista Internacional de Enfermedades Cardiovasculares Revista Española de Cardiología, 57(2), 100.
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Oriol Rodriguez-Leor, Debora Gil, & Eduard Fernandez-Nofrerias. (2006)." Analisis en los cambios en el nivel de gris en las secuencias angiograficas mediante descriptores estadisticos para determinar la perfusion miocardica" . Revista Española de Cardiología, 59 Supl 2-166(2), 128.
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Oriol Rodriguez-Leor, A. Carol, H. Tizon, Eduard Fernandez-Nofrerias, J. Mauri, Vicente del Valle, et al. (2005)." Model estadístic-determinístic per la segmentació de l adventicia en imatges d ecografía intracoronaria" . Rev Societat Catalana Cardiologia, 5, 41.
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