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Author |
Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux |
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Title |
Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function |
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Conference Article |
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2008 |
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8th World Congress on Computational Mechanichs (WCCM8) |
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Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance. |
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Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model. |
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Venice; Italy |
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9788496736559 |
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IAM; |
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IAM @ iam @ GGV2008b |
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993 |
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Author |
C. Santa-Marta; Jaume Garcia; A. Bajo; J.J. Vaquero; M. Ledesma-Carbayo; Debora Gil |
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Title |
Influence of the Temporal Resolution on the Quantification of Displacement Fields in Cardiac Magnetic Resonance Tagged Images |
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Conference Article |
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2008 |
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XXVI Congreso Anual de la Sociedad Española de Ingenieria Biomedica |
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352–353 |
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It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%. |
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Valladolid |
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Roberto hornero, Saniel Abasolo |
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CASEIB |
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IAM @ iam @ SGB2008 |
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1033 |
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Robert Benavente; Ernest Valveny; Jaume Garcia; Agata Lapedriza; Miquel Ferrer; Gemma Sanchez |
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Una experiencia de adaptacion al EEES de las asignaturas de programacion en Ingenieria Informatica |
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Miscellaneous |
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2008 |
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V Congreso Iberoamericano de Docencia Universitaria, pp. 213–216 |
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Valencia |
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OR;DAG;CIC;MV |
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BCNPCL @ bcnpcl @ BVG2008 |
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1031 |
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Author |
Mariano Vazquez; Ruth Aris; Guillaume Hozeaux; R.Aubry; P.Villar;Jaume Garcia ; Debora Gil; Francesc Carreras |
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Title |
A massively parallel computational electrophysiology model of the heart |
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Journal Article |
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2011 |
Publication |
International Journal for Numerical Methods in Biomedical Engineering |
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IJNMBE |
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27 |
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1911-1929 |
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Keywords |
computational electrophysiology; parallelization; finite element methods |
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This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale. |
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Swansea (UK) |
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John Wiley & Sons, Ltd. |
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John Wiley & Sons, Ltd. |
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IAM @ iam @ VAH2011 |
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1198 |
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Author |
Jaume Garcia; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva |
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Title |
An intuitive validation technique to compare local versus global tagged MRI analysis |
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Conference Article |
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2005 |
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Computers In Cardiology |
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32 |
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29–32 |
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Myocardium appears as a uniform tissue that seen in convectional Magnetic Resonance Images (MRI) shows just the contractile part of its movement. MR Tagging is a unique imaging technique that prints a grid over the tissue which moves according to the underlying movement of the myocardium revealing the true deformation of the cardiac muscle. Optical flow techniques based on spectral information estimate tissue displacement by analyzing information encoded in the phase maps which can be obtained using, local (Gabor) and global (HARP) methods. In this paper we compare both in synthetic and real Tagged MR sequences. We conclude that local method is slightly more accurate than the global one. On the other hand, global method is more efficient as it is much faster and less parameters have to be taken into account |
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Lyon (France) |
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0-7803-9337-6 |
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IAM;MILAB |
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IAM @ iam @ GBC2005 |
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639 |
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Author |
Albert Andaluz; Francesc Carreras; Debora Gil; Jaume Garcia |
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Title |
Una aplicació amigable pel càlcul de indicadors clínics del ventricle esquerre |
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Miscellaneous |
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2010 |
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Forum Biocat 2010 |
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Lonja de Mar,Barcelona (Spain) |
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CVC |
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Biocat |
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Barcelona |
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Catalan |
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IAM @ iam @ ACG2010 |
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1483 |
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Author |
Jaume Garcia |
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Propagacio de fronts per a la segmentacio en imatges IVUS |
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2002 |
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Technical Report |
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65 |
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CVC (UAB) |
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IAM @ iam @ Gar2002 |
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328 |
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Author |
Jaume Garcia |
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Title |
Generalized Active Shape Models Applied to Cardiac Function Analysis |
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2004 |
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CVC Technical Report |
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78 |
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Cardiac Analysis; Deformable Models; Active Contour Models; Active Shape Models; Tagged MRI; HARP; Contrast Echocardiography. |
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Medical imaging is very useful in the assessment and treatment of many diseases. To deal with the great amount of data provided by imaging scanners and extract quantitative information that physicians can interpret, many analysis algorithms have been developed. Any process of analysis always consists of a first step of segmenting some particular structure. In medical imaging, structures are not always well defined and suffer from noise artifacts thus, ordinary segmentation methods are not well suited. The ones that seem to give better results are those based on deformable models. Nevertheless, despite their capability of mixing image features together with smoothness constraints that may compensate for image irregularities, these are naturally local methods, i. e., each node of the active contour evolve taking into account information about its neighbors and some other weak constraints about flexibility and smoothness, but not about the global shape that they should find. Due to the fact that structures to be segmented are the same for all cases but with some inter and intra-patient variation, the incorporation of a priori knowledge about shape in the segmentation method will provide robustness to it. Active Shape Models is an algorithm based on the creation of a shape model called Point Distribution Model. It performs a segmentation using only shapes similar than those previously learned from a training set that capture most of the variation presented by the structure. This algorithm works by updating shape nodes along a normal segment which often can be too restrictive. For this reason we propose a generalization of this algorithm that we call Generalized Active Shape Models and fully integrates the a priori knowledge given by the Point Distribution Model with deformable models or any other appropriate segmentation method. Two different applications to cardiac imaging of this generalized method are developed and promising results are shown. |
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CVC (UAB) |
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Master's thesis |
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IAM; |
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IAM @ iam @ Gar2004 |
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1513 |
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Jaume Garcia; Albert Andaluz; Debora Gil; Francesc Carreras |
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Title |
Decoupled External Forces in a Predictor-Corrector Segmentation Scheme for LV Contours in Tagged MR Images |
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2010 |
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32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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4805-4808 |
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Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictorcorrector (Active Contours – Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores. |
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Buenos Aires (Argentina) |
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IEEE EMB |
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1557-170X |
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978-1-4244-4123-5 |
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EMBC |
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IAM @ iam @ GAG2010 |
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1514 |
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Author |
Agata Lapedriza; Jaume Garcia; Ernest Valveny; Robert Benavente; Miquel Ferrer; Gemma Sanchez |
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Una experiencia de aprenentatge basada en projectes en el ambit de la informatica |
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2008 |
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V Jornades d’Innovacio Docent (UAB) |
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63 |
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Bellaterra (Spain) |
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OR; IAM; DAG; CIC; MV |
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BCNPCL @ bcnpcl @ LGV2008 |
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1030 |
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