Abstract: Radiomics is an emerging technique for the quantification of imaging data that has recently shown great promise for deeper phenotyping of cardiovascular disease. Thus far, the technique has been mostly applied in single-centre studies. However, one of the main difficulties in multi-centre imaging studies is the inherent variability of image characteristics due to centre differences. In this paper, a comprehensive analysis of radiomics variability under several image- and feature-based normalisation techniques was conducted using a multi-centre cardiovascular magnetic resonance dataset. 218 subjects divided into healthy (n = 112) and hypertrophic cardiomyopathy (n = 106, HCM) groups from five different centres were considered. First and second order texture radiomic features were extracted from three regions of interest, namely the left and right ventricular cavities and the left ventricular myocardium. Two methods were used to assess features’ variability. First, feature distributions were compared across centres to obtain a distribution similarity index. Second, two classification tasks were proposed to assess: (1) the amount of centre-related information encoded in normalised features (centre identification) and (2) the generalisation ability for a classification model when trained on these features (healthy versus HCM classification). The results showed that the feature-based harmonisation technique ComBat is able to remove the variability introduced by centre information from radiomic features, at the expense of slightly degrading classification performance. Piecewise linear histogram matching normalisation gave features with greater generalisation ability for classification ( balanced accuracy in between 0.78 ± 0.08 and 0.79 ± 0.09). Models trained with features from images without normalisation showed the worst performance overall ( balanced accuracy in between 0.45 ± 0.28 and 0.60 ± 0.22). In conclusion, centre-related information removal did not imply good generalisation ability for classification.

Abstract: Handwritten text recognition in low resource scenarios, such as manuscripts with rare alphabets, is a challenging problem. In this paper, we propose a few-shot learning-based handwriting recognition approach that significantly reduces the human annotation process, by requiring only a few images of each alphabet symbols. The method consists of detecting all the symbols of a given alphabet in a textline image and decoding the obtained similarity scores to the final sequence of transcribed symbols. Our model is first pretrained on synthetic line images generated from an alphabet, which could differ from the alphabet of the target domain. A second training step is then applied to reduce the gap between the source and the target data. Since this retraining would require annotation of thousands of handwritten symbols together with their bounding boxes, we propose to avoid such human effort through an unsupervised progressive learning approach that automatically assigns pseudo-labels to the unlabeled data. The evaluation on different datasets shows that our model can lead to competitive results with a significant reduction in human effort. The code will be publicly available in the following repository: https://github.com/dali92002/HTRbyMatching

Abstract: Rain removal plays an important role in the restoration of degraded images. Recently, CNN-based methods have achieved remarkable success. However, these approaches neglect that the appearance of real-world rain is often accompanied by low light conditions, which will further degrade the image quality, thereby hindering the restoration mission. Therefore, it is very indispensable to jointly remove the rain and enhance illumination for real-world rain image restoration. To this end, we proposed a novel spatially-adaptive network, dubbed SANet, which can remove the rain and enhance illumination in one go with the guidance of degradation mask. Meanwhile, to fully utilize negative samples, a contrastive loss is proposed to preserve more natural textures and consistent illumination. In addition, we present a new synthetic dataset, named DarkRain, to boost the development of rain image restoration algorithms in practical scenarios. DarkRain not only contains different degrees of rain, but also considers different lighting conditions, and more realistically simulates real-world rainfall scenarios. SANet is extensively evaluated on the proposed dataset and attains new state-of-the-art performance against other combining methods. Moreover, after a simple transformation, our SANet surpasses existing the state-of-the-art algorithms in both rain removal and low-light image enhancement.

Abstract: This paper presents an algorithm for automated detection and classification of multi-cell phytoliths, one of the major components of many archaeological and paleoenvironmental deposits. This identification, based on phytolith wave pattern, is made using a pretrained VGG19 deep learning model. This approach has been tested in three key phytolith genera for the study of agricultural origins in Near East archaeology: Avena, Hordeum and Triticum. Also, this classification has been validated at species-level using Triticum boeoticum and dicoccoides images. Due to the diversity of microscopes, cameras and chemical treatments that can influence images of phytolith slides, three types of data augmentation techniques have been implemented: rotation of the images at 45-degree angles, random colour and brightness jittering, and random blur/sharpen. The implemented workflow has resulted in an overall accuracy of 93.68% for phytolith genera, improving previous attempts. The algorithm has also demonstrated its potential to automatize the classification of phytoliths species with an overall accuracy of 100%. The open code and platforms employed to develop the algorithm assure the method's accessibility, reproducibility and reusability.

Abstract: Outlier detection is essential for optimal performance of machine learning methods and statistical predictive models. Their detection is especially determinant in small sample size unbalanced problems, since in such settings outliers become highly influential and significantly bias models. This particular experimental settings are usual in medical applications, like diagnosis of rare pathologies, outcome of experimental personalized treatments or pandemic emergencies. In contrast to population-based methods, neighborhood based local approaches compute an outlier score from the neighbors of each sample, are simple flexible methods that have the potential to perform well in small sample size unbalanced problems. A main concern of local approaches is the impact that the computation of each sample neighborhood has on the method performance. Most approaches use a distance in the feature space to define a single neighborhood that requires careful selection of several parameters, like the number of neighbors.
This work presents a local approach based on a local measure of the heterogeneity of sample labels in the feature space considered as a topological manifold. Topology is computed using the communities of a weighted graph codifying mutual nearest neighbors in the feature space. This way, we provide with a set of multiple neighborhoods able to describe the structure of complex spaces without parameter fine tuning. The extensive experiments on real-world and synthetic data sets show that our approach outperforms, both, local and global strategies in multi and single view settings.

Abstract: In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions.

Abstract: Despite recent advances in automatic text recognition, the performance remains moderate when it comes to historical manuscripts. This is mainly because of the scarcity of available labelled data to train the data-hungry Handwritten Text Recognition (HTR) models. The Keyword Spotting System (KWS) provides a valid alternative to HTR due to the reduction in error rate, but it is usually limited to a closed reference vocabulary. In this paper, we propose a few-shot learning paradigm for spotting sequences of a few characters (N-gram) that requires a small amount of labelled training data. We exhibit that recognition of important n-grams could reduce the system’s dependency on vocabulary. In this case, an out-of-vocabulary (OOV) word in an input handwritten line image could be a sequence of n-grams that belong to the lexicon. An extensive experimental evaluation of our proposed multi-representation approach was carried out on a subset of Bentham’s historical manuscript collections to obtain some really promising results in this direction.

Abstract: Assessing the quality of movements for post-stroke patients during the rehabilitation phase is vital given that there is no standard stroke rehabilitation plan for all the patients. In fact, it depends basically on the patient’s functional independence and its progress along the rehabilitation sessions. To tackle this challenge and make neurorehabilitation more agile, we propose an automatic assessment pipeline that starts by recognising patients’ movements by means of a shallow deep learning architecture, then measuring the movement quality using jerk measure and related measures. A particularity of this work is that the dataset used is clinically relevant, since it represents movements inspired from Fugl-Meyer a well common upper-limb clinical stroke assessment scale for stroke patients. We show that it is possible to detect the contrast between healthy and patients movements in terms of smoothness, besides achieving conclusions about the patients’ progress during the rehabilitation sessions that correspond to the clinicians’ findings about each case.