Abstract: In the early twenty first century Given Imaging Ltd. presented wireless capsule endoscopy (WCE) as a new technological breakthrough that allowed the visualization of
the intestine by using a small, swallowed camera. This small size device was received
with a high enthusiasm within the medical community, and until now, it is still one
of the medical devices with the highest use growth rate. WCE can be used as a novel
diagnostic tool that presents several clinical advantages, since it is non-invasive and
at the same time it provides, for the first time, a full picture of the small bowel morphology, contents and dynamics. Since its appearance, the WCE has been used to
detect several intestinal dysfunctions such as: polyps, ulcers and bleeding. However,
the visual analysis of WCE videos presents an important drawback: the long time
required by the physicians for proper video visualization. In this sense and regarding
to this limitation, the development of computer aided systems is required for the extensive use of WCE in the medical community.
The work presented in this thesis is a set of contributions for the automatic image
analysis and computer-aided diagnosis of intestinal motility disorders using WCE.
Until now, the diagnosis of small bowel motility dysfunctions was basically performed
by invasive techniques such as the manometry test, which can only be conducted at
some referral centers around the world owing to the complexity of the procedure and
the medial expertise required in the interpretation of the results.
Our contributions are divided in three main blocks:
1. Image analysis by computer vision techniques to detect events in the endoluminal WCE scene. Several methods have been proposed to detect visual events
such as: intestinal contractions, intestinal content, tunnel and wrinkles;
2. Machine learning techniques for the analysis and the manipulation of the data
from WCE. These methods have been proposed in order to overcome the problems that the analysis of WCE presents such as: video acquisition cost, unlabeled data and large number of data;
3. Two different systems for the computer-aided diagnosis of intestinal motility
disorders using WCE. The first system presents a fully automatic method that
aids at discriminating healthy subjects from patients with severe intestinal motor disorders like pseudo-obstruction or food intolerance. The second system presents another automatic method that models healthy subjects and discriminate them from mild intestinal motility patients.

Abstract: Put succinctly, the bag-of-words based image representation is the most successful approach for object and scene recognition. Within the bag-of-words framework the optimal fusion of multiple cues, such as shape, texture and color, still remains an active research domain. There exist two main approaches to combine color and shape information within the bag-of-words framework. The first approach called, early fusion, fuses color and shape at the feature level as a result of which a joint colorshape vocabulary is produced. The second approach, called late fusion, concatenates histogram representation of both color and shape, obtained independently. In the first part of this thesis, we analyze the theoretical implications of both early and late feature fusion. We demonstrate that both these approaches are suboptimal for a subset of object categories. Consequently, we propose a novel method for recognizing object categories when using multiple cues by separately processing the shape and color cues and combining them by modulating the shape features by category specific color attention. Color is used to compute bottom-up and top-down attention maps. Subsequently, the color attention maps are used to modulate the weights of the shape features. Shape features are given more weight in regions with higher attention and vice versa. The approach is tested on several benchmark object recognition data sets and the results clearly demonstrate the effectiveness of our proposed method. In the second part of the thesis, we investigate the problem of obtaining compact spatial pyramid representations for object and scene recognition. Spatial pyramids have been successfully applied to incorporate spatial information into bag-of-words based image representation. However, a major drawback of spatial pyramids is that it leads to high dimensional image representations. We present a novel framework for obtaining compact pyramid representation. The approach reduces the size of a high dimensional pyramid representation upto an order of magnitude without any significant reduction in accuracy. Moreover, we also investigate the optimal combination of multiple features such as color and shape within the context of our compact pyramid representation. Finally, we describe a novel technique to build discriminative visual words from multiple cues learned independently from training images. To this end, we use an information theoretic vocabulary compression technique to find discriminative combinations of visual cues and the resulting visual vocabulary is compact, has the cue binding property, and supports individual weighting of cues in the final image representation. The approach is tested on standard object recognition data sets. The results obtained clearly demonstrate the effectiveness of our approach.

Abstract: Video synchronization and alignment is a rather recent topic in computer vision. It usually deals with the problem of aligning sequences recorded simultaneously by static, jointly- or independently-moving cameras. In this paper, we investigate the more difficult problem of matching videos captured at different times from independently-moving cameras, whose trajectories are approximately coincident or parallel. To this end, we propose a novel method that pixel-wise aligns videos and allows thus to automatically highlight their differences. This primarily aims at visual surveillance but the method can be adopted as is by other related video applications, like object transfer (augmented reality) or high dynamic range video. We build upon a slice matching scheme to first synchronize the sequences, while we develop a spatio-temporal alignment scheme to spatially register corresponding frames and refine the temporal mapping. We investigate the performance of the proposed method on videos recorded from vehicles driven along different types of roads and compare with related previous works.

Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.