Abstract: Cone regression is a particular case of quadratic programming that minimizes a weighted sum of squared residuals under a set of linear inequality constraints. Several important statistical problems such as isotonic, concave regression or ANOVA under partial orderings, just to name a few, can be considered as particular instances of the cone regression problem. Given its relevance in Statistics, this paper aims to address the fundamentals of cone regression from a theoretical and practical point of view. Several formulations of the cone regression problem are considered and, focusing on the particular case of concave regression as an example, several algorithms are analyzed and compared both qualitatively and quantitatively through numerical simulations. Several improvements to enhance numerical stability and bound the computational cost are proposed. For each analyzed algorithm, the pseudo-code and its corresponding code in Matlab are provided. The results from this study demonstrate that the choice of the optimization approach strongly impacts the numerical performances. It is also shown that methods are not currently available to solve efficiently cone regression problems with large dimension (more than many thousands of points). We suggest further research to fill this gap by exploiting and adapting classical multi-scale strategy to compute an approximate solution.

Abstract: Despite the large amount of methods and applications of augmented reality, there is little homogenizatio n on the software platforms that support them. An exception may be the low level control software that is provided by some high profile vendors such as Qualcomm and Metaio. However, these provide fine grain modules for e.g. element tracking. We are more co ncerned on the application framework, that includes the control of the devices working together for the development of the AR experience. In this paper we describe the development of a software framework for AR setups. We concentrate on the modular design of the framework, but also on some hard problems such as the calibration stage, crucial for projection – based AR. The developed framework is suitable and has been tested in AR applications using camera – projector pairs, for both fixed and nomadic setups

Abstract: In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation.

Abstract: INTRODUCTION:
Sleep surfaces must adapt to individual somatotypic features to maintain a comfortable, convenient and healthy sleep, preventing diseases and injuries. Individually determining the most adequate rest surface can often be a complex and subjective question.
OBJECTIVES:
To design and validate an automatic multimodal somatotype determination model to automatically recommend an individually designed mattress-topper-pillow combination.
METHODS:
Design and validation of an automated prescription model for an individualised sleep system is performed through a single-image 2 D-3 D analysis and body pressure distribution, to objectively determine optimal individual sleep surfaces combining five different mattress densities, three different toppers and three cervical pillows.
RESULTS:
A final study (n = 151) and re-analysis (n = 117) defined and validated the model, showing high correlations between calculated and real data (>85% in height and body circumferences, 89.9% in weight, 80.4% in body mass index and more than 70% in morphotype categorisation).
CONCLUSIONS:
Somatotype determination model can accurately prescribe an individualised sleep solution. This can be useful for healthy people and for health centres that need to adapt sleep surfaces to people with special needs. Next steps will increase model's accuracy and analise, if this prescribed individualised sleep solution can improve sleep quantity and quality; additionally, future studies will adapt the model to mattresses with technological improvements, tailor-made production and will define interfaces for people with special needs.

Abstract: Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.

Abstract: With the ongoing progress in digitization, huge document collections and archives have become available to a broad audience. Scanned document images can be transmitted electronically and studied simultaneously throughout the world. While this is very beneficial, it is often impossible to perform automated searches on these document collections. Optical character recognition usually fails when it comes to handwritten or historic documents. In order to address the need for exploring document collections rapidly, researchers are working on word spotting. In query-by-example word spotting scenarios, the user selects an exemplary occurrence of the query word in a document image. The word spotting system then retrieves all regions in the collection that are visually similar to the given example of the query word. The best matching regions are presented to the user and no actual transcription is required.
An important property of a word spotting system is the computational speed with which queries can be executed. In our previous work, we presented a relatively slow but high-precision method. In the present work, we will extend this baseline system to an integrated two-stage approach. In a coarse-grained first stage, we will filter document images efficiently in order to identify regions that are likely to contain the query word. In the fine-grained second stage, these regions will be analyzed with our previously presented high-precision method. Finally, we will report recognition results and query times for the well-known George Washington
benchmark in our evaluation. We achieve state-of-the-art recognition results while the query times can be reduced to 50% in comparison with our baseline.

Abstract: In this article, a form of the so-called word spotting-method is used on a large set of handwritten documents in order to identify those that contain script of similar execution. The point of departure for the investigation is the mediaeval Swedish manuscript Cod. Holm. D 3. The main scribe of this manuscript has yet not been identified in other documents. The current attempt aims at localising other documents that display a large degree of similarity in the characteristics of the script, these being possible candidates for being executed by the same hand. For this purpose, the method of word spotting has been employed, focusing on individual letters, and therefore the process is referred to as letter spotting in the article. In this process, a set of ‘g’:s, ‘h’:s and ‘k’:s have been selected as templates, and then a search has been made for close matches among the mediaeval Swedish charters. The search resulted in a number of charters that displayed great similarities with the manuscript D 3. The used letter spotting method thus proofed to be a very efficient sorting tool localising similar script samples.