Abstract: Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.

Abstract: The emergence of geometric deep learning as a novel framework to deal with graph-based representations has faded away traditional approaches in favor of completely new methodologies. In this paper, we propose a new framework able to combine the advances on deep metric learning with traditional approximations of the graph edit distance. Hence, we propose an efficient graph distance based on the novel field of geometric deep learning. Our method employs a message passing neural network to capture the graph structure, and thus, leveraging this information for its use on a distance computation. The performance of the proposed graph distance is validated on two different scenarios. On the one hand, in a graph retrieval of handwritten words i.e. keyword spotting, showing its superior performance when compared with (approximate) graph edit distance benchmarks. On the other hand, demonstrating competitive results for graph similarity learning when compared with the current state-of-the-art on a recent benchmark dataset.

Abstract: Handwritten document images can be highly affected by degradation for different reasons: Paper ageing, daily-life scenarios (wrinkles, dust, etc.), bad scanning process and so on. These artifacts raise many readability issues for current Handwritten Text Recognition (HTR) algorithms and severely devalue their efficiency. In this paper, we propose an end to end architecture based on Generative Adversarial Networks (GANs) to recover the degraded documents into a and form. Unlike the most well-known document binarization methods, which try to improve the visual quality of the degraded document, the proposed architecture integrates a handwritten text recognizer that promotes the generated document image to be more readable. To the best of our knowledge, this is the first work to use the text information while binarizing handwritten documents. Extensive experiments conducted on degraded Arabic and Latin handwritten documents demonstrate the usefulness of integrating the recognizer within the GAN architecture, which improves both the visual quality and the readability of the degraded document images. Moreover, we outperform the state of the art in H-DIBCO challenges, after fine tuning our pre-trained model with synthetically degraded Latin handwritten images, on this task.

Abstract: This work addresses the problem of Question Answering (QA) on handwritten document collections. Unlike typical QA and Visual Question Answering (VQA) formulations where the answer is a short text, we aim to locate a document snippet where the answer lies. The proposed approach works without recognizing the text in the documents. We argue that the recognition-free approach is suitable for handwritten documents and historical collections where robust text recognition is often difficult. At the same time, for human users, document image snippets containing answers act as a valid alternative to textual answers. The proposed approach uses an off-the-shelf deep embedding network which can project both textual words and word images into a common sub-space. This embedding bridges the textual and visual domains and helps us retrieve document snippets that potentially answer a question. We evaluate results of the proposed approach on two new datasets: (i) HW-SQuAD: a synthetic, handwritten document image counterpart of SQuAD1.0 dataset and (ii) BenthamQA: a smaller set of QA pairs defined on documents from the popular Bentham manuscripts collection. We also present a thorough analysis of the proposed recognition-free approach compared to a recognition-based approach which uses text recognized from the images using an OCR. Datasets presented in this work are available to download at docvqa.org.

Abstract: Eating habits are learned throughout the early stages of our lives. However, it is not easy to be aware of how our food-related routine affects our healthy living. In this work, we address the unsupervised discovery of nutritional habits from egocentric photo-streams. We build a food-related behavioral pattern discovery model, which discloses nutritional routines from the activities performed throughout the days. To do so, we rely on Dynamic-Time-Warping for the evaluation of similarity among the collected days. Within this framework, we present a simple, but robust and fast novel classification pipeline that outperforms the state-of-the-art on food-related image classification with a weighted accuracy and F-score of 70% and 63%, respectively. Later, we identify days composed of nutritional activities that do not describe the habits of the person as anomalies in the daily life of the user with the Isolation Forest method. Furthermore, we show an application for the identification of food-related scenes when the camera wearer eats in isolation. Results have shown the good performance of the proposed model and its relevance to visualize the nutritional habits of individuals.

Abstract: We present a methodology to automatically obtain Pose Space Deformation (PSD) basis for rigged garments through deep learning. Classical approaches rely on Physically Based Simulations (PBS) to animate clothes. These are general solutions that, given a sufficiently fine-grained discretization of space and time, can achieve highly realistic results. However, they are computationally expensive and any scene modification prompts the need of re-simulation. Linear Blend Skinning (LBS) with PSD offers a lightweight alternative to PBS, though, it needs huge volumes of data to learn proper PSD. We propose using deep learning, formulated as an implicit PBS, to unsupervisedly learn realistic cloth Pose Space Deformations in a constrained scenario: dressed humans. Furthermore, we show it is possible to train these models in an amount of time comparable to a PBS of a few sequences. To the best of our knowledge, we are the first to propose a neural simulator for cloth.
While deep-based approaches in the domain are becoming a trend, these are data-hungry models. Moreover, authors often propose complex formulations to better learn wrinkles from PBS data. Supervised learning leads to physically inconsistent predictions that require collision solving to be used. Also, dependency on PBS data limits the scalability of these solutions, while their formulation hinders its applicability and compatibility. By proposing an unsupervised methodology to learn PSD for LBS models (3D animation standard), we overcome both of these drawbacks. Results obtained show cloth-consistency in the animated garments and meaningful pose-dependant folds and wrinkles. Our solution is extremely efficient, handles multiple layers of cloth, allows unsupervised outfit resizing and can be easily applied to any custom 3D avatar.