Abstract: Domain Adaptation (DA) has recently raised strong interests in the medical imaging community. While a large variety of DA techniques has been proposed for image segmentation, most of these techniques have been validated either on private datasets or on small publicly available datasets. Moreover, these datasets mostly addressed single-class problems. To tackle these limitations, the Cross-Modality Domain Adaptation (crossMoDA) challenge was organised in conjunction with the 24th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2021). CrossMoDA is the first large and multi-class benchmark for unsupervised cross-modality DA. The challenge's goal is to segment two key brain structures involved in the follow-up and treatment planning of vestibular schwannoma (VS): the VS and the cochleas. Currently, the diagnosis and surveillance in patients with VS are performed using contrast-enhanced T1 (ceT1) MRI. However, there is growing interest in using non-contrast sequences such as high-resolution T2 (hrT2) MRI. Therefore, we created an unsupervised cross-modality segmentation benchmark. The training set provides annotated ceT1 (N=105) and unpaired non-annotated hrT2 (N=105). The aim was to automatically perform unilateral VS and bilateral cochlea segmentation on hrT2 as provided in the testing set (N=137). A total of 16 teams submitted their algorithm for the evaluation phase. The level of performance reached by the top-performing teams is strikingly high (best median Dice – VS:88.4%; Cochleas:85.7%) and close to full supervision (median Dice – VS:92.5%; Cochleas:87.7%). All top-performing methods made use of an image-to-image translation approach to transform the source-domain images into pseudo-target-domain images. A segmentation network was then trained using these generated images and the manual annotations provided for the source image.

Abstract: This paper presents two algorithms for the large-scale automatic detection and instance segmentation of potential archaeological mounds on historical maps. Historical maps present a unique source of information for the reconstruction of ancient landscapes. The last 100 years have seen unprecedented landscape modifications with the introduction and large-scale implementation of mechanised agriculture, channel-based irrigation schemes, and urban expansion to name but a few. Historical maps offer a window onto disappearing landscapes where many historical and archaeological elements that no longer exist today are depicted. The algorithms focus on the detection and shape extraction of mound features with high probability of being archaeological settlements, mounds being one of the most commonly documented archaeological features to be found in the Survey of India historical map series, although not necessarily recognised as such at the time of surveying. Mound features with high archaeological potential are most commonly depicted through hachures or contour-equivalent form-lines, therefore, an algorithm has been designed to detect each of those features. Our proposed approach addresses two of the most common issues in archaeological automated survey, the low-density of archaeological features to be detected, and the small amount of training data available. It has been applied to all types of maps available of the historic 1″ to 1-mile series, thus increasing the complexity of the detection. Moreover, the inclusion of synthetic data, along with a Curriculum Learning strategy, has allowed the algorithm to better understand what the mound features look like. Likewise, a series of filters based on topographic setting, form, and size have been applied to improve the accuracy of the models. The resulting algorithms have a recall value of 52.61% and a precision of 82.31% for the hachure mounds, and a recall value of 70.80% and a precision of 70.29% for the form-line mounds, which allowed the detection of nearly 6000 mound features over an area of 470,500 km2, the largest such approach to have ever been applied. If we restrict our focus to the maps most similar to those used in the algorithm training, we reach recall values greater than 60% and precision values greater than 90%. This approach has shown the potential to implement an adaptive algorithm that allows, after a small amount of retraining with data detected from a new map, a better general mound feature detection in the same map.

Abstract: Deep neural networks represent a compelling technique to tackle complex real-world problems, but are over-parameterized and often suffer from over- or under-confident estimates. Deep ensembles have shown better parameter estimations and often provide reliable uncertainty estimates that contribute to the robustness of the results. In this work, we propose a new metric to identify samples that are hard to classify. Our metric is defined as coincidence score for deep ensembles which measures the agreement of its individual models. The main hypothesis we rely on is that deep learning algorithms learn the low-loss samples better compared to large-loss samples. In order to compensate for this, we use controlled over-sampling on the identified ”hard” samples using proper data augmentation schemes to enable the models to learn those samples better. We validate the proposed metric using two public food datasets on different backbone architectures and show the improvements compared to the conventional deep neural network training using different performance metrics.

Abstract: For millennia, the study of the couple brain-mind has fascinated the humanity in order to understand the complex nature of cognitive states. A cognitive state is the state of the mind at a specific time and involves cognition activities to acquire and process information for making a decision, solving a problem, or achieving a goal.
While normal cognitive states assist in the successful accomplishment of tasks; on the contrary, abnormal states of the mind can lead to task failures due to a reduced cognition capability. In this thesis, we focus on the assessment of cognitive states by means of the analysis of ElectroEncephaloGrams (EEG) signals using deep learning methods. EEG records the electrical activity of the brain using a set of electrodes placed on the scalp that output a set of spatiotemporal signals that are expected to be correlated to a specific mental process.
From the point of view of artificial intelligence, any method for the assessment of cognitive states using EEG signals as input should face several challenges. On the one hand, one should determine which is the most suitable approach for the optimal combination of the multiple signals recorded by EEG electrodes. On the other hand, one should have a protocol for the collection of good quality unambiguous annotated data, and an experimental design for the assessment of the generalization and transfer of models. In order to tackle them, first, we propose several convolutional neural architectures to perform data fusion of the signals recorded by EEG electrodes, at raw signal and feature levels. Four channel fusion methods, easy to incorporate into any neural network architecture, are proposed and assessed. Second, we present a method to create an unambiguous dataset for the prediction of cognitive mental workload using serious games and an Airbus-320 flight simulator. Third, we present a validation protocol that takes into account the levels of generalization of models based on the source and amount of test data.
Finally, the approaches for the assessment of cognitive states are applied to two use cases of high social impact: the assessment of mental workload for personalized support systems in the cockpit and the detection of epileptic seizures. The results obtained from the first use case show the feasibility of task transfer of models trained to detect workload in serious games to real flight scenarios. The results from the second use case show the generalization capability of our EEG channel fusion methods at k-fold cross-validation, patient-specific, and population levels.

Abstract: Edge detection is the basis of many computer vision applications. State of the art predominantly relies on deep learning with two decisive factors: dataset content and network architecture. Most of the publicly available datasets are not curated for edge detection tasks. Here, we address this limitation. First, we argue that edges, contours and boundaries, despite their overlaps, are three distinct visual features requiring separate benchmark datasets. To this end, we present a new dataset of edges. Second, we propose a novel architecture, termed Dense Extreme Inception Network for Edge Detection (DexiNed), that can be trained from scratch without any pre-trained weights. DexiNed outperforms other algorithms in the presented dataset. It also generalizes well to other datasets without any fine-tuning. The higher quality of DexiNed is also perceptually evident thanks to the sharper and finer edges it outputs.

Abstract: This paper presents an innovative architecture based on a Cycle Generative Adversarial Network (CycleGAN) for the synthesis of high-quality depth maps from monocular images. The proposed architecture leverages a diverse set of loss functions, including cycle consistency, contrastive, identity, and least square losses, to facilitate the generation of depth maps that exhibit realism and high fidelity. A notable feature of the approach is its ability to synthesize depth maps from grayscale images without the need for paired training data. Extensive comparisons with different state-of-the-art methods show the superiority of the proposed approach in both quantitative metrics and visual quality. This work addresses the challenge of depth map synthesis and offers significant advancements in the field.

Abstract: This work addresses the detection of Helicobacter pylori a bacterium classified since 1994 as class 1 carcinogen to humans. By its highest specificity and sensitivity, the preferred diagnosis technique is the analysis of histological images with immunohistochemical staining, a process in which certain stained antibodies bind to antigens of the biological element of interest. This analysis is a time demanding task, which is currently done by an expert pathologist that visually inspects the digitized samples.
We propose to use autoencoders to learn latent patterns of healthy tissue and detect H. pylori as an anomaly in image staining. Unlike existing classification approaches, an autoencoder is able to learn patterns in an unsupervised manner (without the need of image annotations) with high performance. In particular, our model has an overall 91% of accuracy with 86\% sensitivity, 96% specificity and 0.97 AUC in the detection of H. pylori.