Abstract: The framework of this thesis is to study in detail different techniques and tools for medical image registration in order to ease the daily life of clinical experts in cardiology. The first aim of this thesis is providing computer tools for
fusing IVUS and angiogram data is of high clinical interest to help the physicians locate in IVUS data and decide which lesion is observed, how long it is, how far from a bifurcation or another lesions stays, etc. This thesis proves and
validates that we can segment the catheter path in angiographies using geodesic snakes (based on fast marching algorithm), a three-dimensional reconstruction of the catheter inspired in stereo vision and a new technique to fuse IVUS
and angiograms that establishes exact correspondences between them. We have developed a new workstation called iFusion that has four strong advantages: registration of IVUS and angiographic images with sub-pixel precision, it works on- and off-line, it is independent on the X-ray system and there is no need of daily calibration. The second aim of the thesis is devoted to developing a computer-aided analysis of IVUS for image-guided intervention. We have designed, implemented
and validated a robust algorithm for stent extraction and reconstruction from IVUS videos. We consider a very special and recent kind of stents, bioabsorbable stents that represent a great clinical challenge due to their property to be
absorbed by time and thus avoiding the “danger” of neostenosis as one of the main problems of metallic stents. We present a new and very promising algorithm based on an optimized cascade of multiple classifiers to automatically detect individual stent struts of a very novel bioabsorbable drug eluting coronary stent. This problem represents a very challenging target given the variability in contrast, shape and grey levels of the regions to be detected, what is
denoted by the high variability between the specialists (inter-observer variability of 0.14~$\pm$0.12). The obtained results of the automatic strut detection are within the inter-observer variability.

Abstract: The analysis and recognition of music scores has attracted the interest of researchers for decades. Optical Music Recognition (OMR) is a classical research field of Document Image Analysis and Recognition (DIAR), whose aim is to extract information from music scores. Music scores contain both graphical and textual information, and for this reason, techniques are closely related to graphics recognition and text recognition. Since music scores use a particular diagrammatic notation that follow the rules of music theory, many approaches make use of context information to guide the recognition and solve ambiguities. This chapter overviews the main Optical Music Recognition (OMR) approaches. Firstly, the different methods are grouped according to the OMR stages, namely, staff removal, music symbol recognition, and syntactical analysis. Secondly, specific approaches for old and handwritten music scores are reviewed. Finally, online approaches and commercial systems are also commented.

Abstract: Counterfeiting and piracy are a form of theft that has been steadily growing in recent years. A counterfeit is an unauthorized reproduction of an authentic/genuine object. Banknotes and identity documents are two common objects of counterfeiting. The former is used by organized criminal groups to finance a variety of illegal activities or even to destabilize entire countries due the inflation effect. Generally, in order to run their illicit businesses, counterfeiters establish companies and bank accounts using fraudulent identity documents. The illegal activities generated by counterfeit banknotes and identity documents has a damaging effect on business, the economy and the general population. To fight against counterfeiters, governments and authorities around the globe cooperate and develop security features to protect their security documents. Many of the security features in identity documents can also be found in banknotes. In this dissertation we focus our efforts in detecting the counterfeit banknotes and identity documents by analyzing the security features at the background printing. Background areas on secure documents contain fine-line patterns and designs that are difficult to reproduce without the manufacturers cutting-edge printing equipment. Our objective is to find the loose of resolution between the genuine security document and the printed counterfeit version with a publicly available commercial printer. We first present the most complete survey to date in identity and banknote security features. The compared algorithms and systems are based on computer vision and machine learning. Then we advance to present the banknote and identity counterfeit dataset we have built and use along all this thesis. Afterwards, we evaluate and adapt algorithms in the literature for the security background texture analysis. We study this problem from the point of view of robustness, computational efficiency and applicability into a real and non-controlled industrial scenario, proposing key insights to use these algorithms. Next, within the industrial environment of this thesis, we build a complete service oriented architecture to detect counterfeit documents. The mobile application and the server framework intends to be used even by non-expert document examiners to spot counterfeits. Later, we re-frame the problem of background texture counterfeit detection as a full-reference game of spotting the differences, by alternating glimpses between a counterfeit and a genuine background using recurrent neural networks. Finally, we deal with the lack of counterfeit samples, studying different approaches based on anomaly detection.

Abstract: Eye tracker devices have traditionally been only used inside laboratories, requiring trained professionals and elaborate setup mechanisms. However, in the recent years the scientific work on easier–to–use eye trackers which require no special hardware—other than the omnipresent front facing cameras in computers, tablets, and mobiles—is aiming at making this technology common–place. These types of trackers have several extra challenges that make the problem harder, such as low resolution images provided by a regular webcam, the changing ambient lighting conditions, personal appearance differences, changes in head pose, and so on. Recent research in the field has focused on all these challenges in order to provide better gaze estimation performances in a real world setup.
In this work, we aim at tackling the gaze tracking problem in a single camera setup. We first analyze all the previous work in the field, identifying the strengths and weaknesses of each tried idea. We start our work on the gaze tracker with an appearance–based gaze estimation method, which is the simplest idea that creates a direct mapping between a rectangular image patch extracted around the eye in a camera image, and the gaze point (or gaze direction). Here, we do an extensive analysis of the factors that affect the performance of this tracker in several experimental setups, in order to address these problems in future works. In the second part of our work, we propose a feature–based gaze estimation method, which encodes the eye region image into a compact representation. We argue that this type of representation is better suited to dealing with head pose and lighting condition changes, as it both reduces the dimensionality of the input (i.e. eye image) and breaks the direct connection between image pixel intensities and the gaze estimation. Lastly, we use a face alignment algorithm to have robust face pose estimation, using a 3D model customized to the subject using the tracker. We combine this with a convolutional neural network trained on a large dataset of images to build a face pose invariant gaze tracker.

Abstract: Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a condent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies.