Abstract: Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation.

Abstract: Humans are capable of learning new tasks without forgetting previous ones, while neural networks fail due to catastrophic forgetting between new and previously-learned tasks. We consider a class-incremental setting which means that the task-ID is unknown at inference time. The imbalance between old and new classes typically results in a bias of the network towards the newest ones. This imbalance problem can either be addressed by storing exemplars from previous tasks, or by using image replay methods. However, the latter can only be applied to toy datasets since image generation for complex datasets is a hard problem.
We propose a solution to the imbalance problem based on generative feature replay which does not require any exemplars. To do this, we split the network into two parts: a feature extractor and a classifier. To prevent forgetting, we combine generative feature replay in the classifier with feature distillation in the feature extractor. Through feature generation, our method reduces the complexity of generative replay and prevents the imbalance problem. Our approach is computationally efficient and scalable to large datasets. Experiments confirm that our approach achieves state-of-the-art results on CIFAR-100 and ImageNet, while requiring only a fraction of the storage needed for exemplar-based continual learning

Abstract: 5Y Impact Factor: 1.14 / 3rd (Computer Science, Artificial Intelligence)
We introduce a model of attentional eye guidance based on the rationale that the deployment of gaze is to be considered in the context of a general action-perception loop relying on two strictly intertwined processes: sensory processing, depending on current gaze position, identifies sources of information that are most valuable under the given task; motor processing links such information with the oculomotor act by sampling the next gaze position and thus performing the gaze shift. In such a framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the payoff of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects. The different levels of the action-perception loop are represented in probabilistic form and eventually give rise to a stochastic process that generates the gaze sequence. This way the model also accounts for statistical properties of gaze shifts such as individual scan path variability. Results of the simulations are compared either with experimental data derived from publicly available datasets and from our own experiments.

Abstract: Mobile document image acquisition integrates many distortions which must be corrected or detected on the device, before the document becomes unavailable or paying data transmission fees. In this paper, we propose a system to correct perspective and illumination issues, and estimate the sharpness of the image for OCR recognition. The correction step relies on fast and accurate border detection followed by illumination normalization. Its evaluation on a private dataset shows a clear improvement on OCR accuracy. The quality assessment
step relies on a combination of focus measures. Its evaluation on a public dataset shows that this simple method compares well to state of the art, learning-based methods which cannot be embedded on a mobile, and outperforms metric-based methods.

Abstract: In this paper we propose an effective method aimed at reducing the amount of local descriptors to be indexed in a document matching framework.In an off-line training stage, the matching between the model document and incoming images is computed retaining the local descriptors from the model that steadily produce good matches. We have evaluated this approach by using the ICDAR2015 SmartDOC dataset containing near 25000 images from documents to be captured by a mobile device. We have tested the performance of this filtering step by using ORB and SIFT local detectors and descriptors. The results show an important gain both in quality of the final matching as well as in time and space requirements.