Abstract: Single image super-resolution (SISR) is an important task in image processing which aims to enhance the resolution of imaging systems. Recently, SISR has witnessed great strides with the rapid development of deep learning. Recent advances in SISR are mostly devoted to designing deeper and wider networks to enhance their representation learning capacity. However, as the depth of networks increases, deep learning-based methods are faced with the challenge of computational complexity in practice. Moreover, most existing methods rarely leverage the intermediate features and also do not discriminate the computation of features by their frequencial components, thereby achieving relatively low performance. Aside from the aforementioned problems, another desired ability is to upsample images to arbitrary scales using a single model. Most current SISR methods train a dedicated model for each target resolution, losing generality and increasing memory requirements. In this thesis, we address the aforementioned issues and propose solutions to them: i) We present a novel frequency-based enhancement block which treats different frequencies in a heterogeneous way and also models inter-channel dependencies, which consequently enrich the output feature. Thus it helps the network generate more discriminative representations by explicitly recovering finer details. ii) We introduce OverNet which contains two main parts: a lightweight feature extractor that follows a novel recursive framework of skip and dense connections to reduce low-level feature degradation, and an overscaling module that generates an accurate SR image by internally constructing an overscaled intermediate representation of the output features. Then, to solve the problem of reconstruction at arbitrary scale factors, we introduce a novel multi-scale loss, that allows the simultaneous training of all scale factors using a single model. iii) We propose a directional variance attention network which leverages a novel attention mechanism to enhance features in different channels and spatial regions. Moreover, we introduce a novel procedure for using attention mechanisms together with residual blocks to facilitate the preservation of finer details. Finally, we demonstrate that our approaches achieve considerably better performance than previous state-of-the-art methods, in terms of both quantitative and visual quality.

Abstract: In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions.

Abstract: Weather prediction from real-world images can be termed a complex task when targeting classification using neural networks. Moreover, the number of images throughout the available datasets can contain a huge amount of variance when comparing locations with the weather those images are representing. In this article, the capabilities of a custom built driver simulator are explored specifically to simulate a wide range of weather conditions. Moreover, the performance of a new synthetic dataset generated by the above simulator is also assessed. The results indicate that the use of synthetic datasets in conjunction with real-world datasets can increase the training efficiency of the CNNs by as much as 74%. The article paves a way forward to tackle the persistent problem of bias in vision-based datasets.

Abstract: The efficiency of lung cancer screening for reducing mortality is hindered by the high rate of false positives. Artificial intelligence applied to radiomics could help to early discard benign cases from the analysis of CT scans. The available amount of data and the fact that benign cases are a minority, constitutes a main challenge for the successful use of state of the art methods (like deep learning), which can be biased, over-fitted and lack of clinical reproducibility. We present an hybrid approach combining the potential of radiomic features to characterize nodules in CT scans and the generalization of the feed forward networks. In order to obtain maximal reproducibility with minimal training data, we propose an embedding of nodules based on the statistical significance of radiomic features for malignancy detection. This representation space of lesions is the input to a feed
forward network, which architecture and hyperparameters are optimized using own-defined metrics of the diagnostic power of the whole system. Results of the best model on an independent set of patients achieve 100% of sensitivity and 83% of specificity (AUC = 0.94) for malignancy detection.

Abstract: The future deployment of single pilot operations must be supported by new cockpit computer services. Such services require an adaptive context-aware integration of technical functionalities with the concurrent tasks that a pilot must deal with. Advanced artificial intelligence supporting services and improved communication capabilities are the key enabling technologies that will render future cockpits more integrated with the present digitalized air traffic management system. However, an issue in the integration of such technologies is the lack of socio-technical analysis in the design of these teaming mechanisms. A key factor in determining how and when a service support should be provided is the dynamic evolution of pilot workload. This paper investigates how the socio-technical model-based systems engineering approach paves the way for the design of a digital assistant framework by formalizing this workload. The model was validated in an Airbus A-320 cockpit simulator, and the results confirmed the degraded pilot behavioral model and the performance impact according to different contextual flight deck information. This study contributes to practical knowledge for designing human-machine task-sharing systems.