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David Roche, Debora Gil, & Jesus Giraldo. (2013). Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models. BJP - British Journal of Pharmacology, 169(6), 1189–202.
Abstract: Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.
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Francesco Ciompi, Oriol Pujol, & Petia Radeva. (2014). ECOC-DRF: Discriminative random fields based on error correcting output codes. PR - Pattern Recognition, 47(6), 2193–2204.
Abstract: We present ECOC-DRF, a framework where potential functions for Discriminative Random Fields are formulated as an ensemble of classifiers. We introduce the label trick, a technique to express transitions in the pairwise potential as meta-classes. This allows to independently learn any possible transition between labels without assuming any pre-defined model. The Error Correcting Output Codes matrix is used as ensemble framework for the combination of margin classifiers. We apply ECOC-DRF to a large set of classification problems, covering synthetic, natural and medical images for binary and multi-class cases, outperforming state-of-the art in almost all the experiments.
Keywords: Discriminative random fields; Error-correcting output codes; Multi-class classification; Graphical models
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Fahad Shahbaz Khan, Shida Beigpour, Joost Van de Weijer, & Michael Felsberg. (2014). Painting-91: A Large Scale Database for Computational Painting Categorization. MVAP - Machine Vision and Applications, 25(6), 1385–1397.
Abstract: Computer analysis of visual art, especially paintings, is an interesting cross-disciplinary research domain. Most of the research in the analysis of paintings involve medium to small range datasets with own specific settings. Interestingly, significant progress has been made in the field of object and scene recognition lately. A key factor in this success is the introduction and availability of benchmark datasets for evaluation. Surprisingly, such a benchmark setup is still missing in the area of computational painting categorization. In this work, we propose a novel large scale dataset of digital paintings. The dataset consists of paintings from 91 different painters. We further show three applications of our dataset namely: artist categorization, style classification and saliency detection. We investigate how local and global features popular in image classification perform for the tasks of artist and style categorization. For both categorization tasks, our experimental results suggest that combining multiple features significantly improves the final performance. We show that state-of-the-art computer vision methods can correctly classify 50 % of unseen paintings to its painter in a large dataset and correctly attribute its artistic style in over 60 % of the cases. Additionally, we explore the task of saliency detection on paintings and show experimental findings using state-of-the-art saliency estimation algorithms.
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Frederic Sampedro, Anna Domenech, & Sergio Escalera. (2014). Static and dynamic computational cancer spread quantification in whole body FDG-PET/CT scans. JMIHI - Journal of Medical Imaging and Health Informatics, 4(6), 825–831.
Abstract: In this work we address the computational cancer spread quantification scenario in whole body FDG-PET/CT scans. At the static level, this setting can be modeled as a clustering problem on the set of 3D connected components of the whole body PET tumoral segmentation mask carried out by nuclear medicine physicians. At the dynamic level, and ad-hoc algorithm is proposed in order to quantify the cancer spread time evolution which, when combined with other existing indicators, gives rise to the metabolic tumor volume-aggressiveness-spread time evolution chart, a novel tool that we claim that would prove useful in nuclear medicine and oncological clinical or research scenarios. Good performance results of the proposed methodologies both at the clinical and technological level are shown using a dataset of 48 segmented whole body FDG-PET/CT scans.
Keywords: CANCER SPREAD; COMPUTER AIDED DIAGNOSIS; MEDICAL IMAGING; TUMOR QUANTIFICATION
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Carles Sanchez, Jorge Bernal, F. Javier Sanchez, Antoni Rosell, Marta Diez-Ferrer, & Debora Gil. (2015). Towards On-line Quantification of Tracheal Stenosis from Videobronchoscopy. IJCAR - International Journal of Computer Assisted Radiology and Surgery, 10(6), 935–945.
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Carles Sanchez, Jorge Bernal, F. Javier Sanchez, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2015). Towards On-line Quantification of Tracheal Stenosis from Videobronchoscopy. In 6th International Conference on Information Processing in Computer-Assisted Interventions IPCAI2015 (Vol. 10, pp. 935–945).
Abstract: PURPOSE:
Lack of objective measurement of tracheal obstruction degree has a negative impact on the chosen treatment prone to lead to unnecessary repeated explorations and other scanners. Accurate computation of tracheal stenosis in videobronchoscopy would constitute a breakthrough for this noninvasive technique and a reduction in operation cost for the public health service.
METHODS:
Stenosis calculation is based on the comparison of the region delimited by the lumen in an obstructed frame and the region delimited by the first visible ring in a healthy frame. We propose a parametric strategy for the extraction of lumen and tracheal ring regions based on models of their geometry and appearance that guide a deformable model. To ensure a systematic applicability, we present a statistical framework to choose optimal parametric values and a strategy to choose the frames that minimize the impact of scope optical distortion.
RESULTS:
Our method has been tested in 40 cases covering different stenosed tracheas. Experiments report a non- clinically relevant [Formula: see text] of discrepancy in the calculated stenotic area and a computational time allowing online implementation in the operating room.
CONCLUSIONS:
Our methodology allows reliable measurements of airway narrowing in the operating room. To fully assess its clinical impact, a prospective clinical trial should be done.
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Carolina Malagelada, Michal Drozdzal, Santiago Segui, Sara Mendez, Jordi Vitria, Petia Radeva, et al. (2015). Classification of functional bowel disorders by objective physiological criteria based on endoluminal image analysis. AJPGI - American Journal of Physiology-Gastrointestinal and Liver Physiology, 309(6), G413–G419.
Abstract: We have previously developed an original method to evaluate small bowel motor function based on computer vision analysis of endoluminal images obtained by capsule endoscopy. Our aim was to demonstrate intestinal motor abnormalities in patients with functional bowel disorders by endoluminal vision analysis. Patients with functional bowel disorders (n = 205) and healthy subjects (n = 136) ingested the endoscopic capsule (Pillcam-SB2, Given-Imaging) after overnight fast and 45 min after gastric exit of the capsule a liquid meal (300 ml, 1 kcal/ml) was administered. Endoluminal image analysis was performed by computer vision and machine learning techniques to define the normal range and to identify clusters of abnormal function. After training the algorithm, we used 196 patients and 48 healthy subjects, completely naive, as test set. In the test set, 51 patients (26%) were detected outside the normal range (P < 0.001 vs. 3 healthy subjects) and clustered into hypo- and hyperdynamic subgroups compared with healthy subjects. Patients with hypodynamic behavior (n = 38) exhibited less luminal closure sequences (41 ± 2% of the recording time vs. 61 ± 2%; P < 0.001) and more static sequences (38 ± 3 vs. 20 ± 2%; P < 0.001); in contrast, patients with hyperdynamic behavior (n = 13) had an increased proportion of luminal closure sequences (73 ± 4 vs. 61 ± 2%; P = 0.029) and more high-motion sequences (3 ± 1 vs. 0.5 ± 0.1%; P < 0.001). Applying an original methodology, we have developed a novel classification of functional gut disorders based on objective, physiological criteria of small bowel function.
Keywords: capsule endoscopy; computer vision analysis; functional bowel disorders; intestinal motility; machine learning
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Alejandro Gonzalez Alzate, Zhijie Fang, Yainuvis Socarras, Joan Serrat, David Vazquez, Jiaolong Xu, et al. (2016). Pedestrian Detection at Day/Night Time with Visible and FIR Cameras: A Comparison. SENS - Sensors, 16(6), 820.
Abstract: Despite all the significant advances in pedestrian detection brought by computer vision for driving assistance, it is still a challenging problem. One reason is the extremely varying lighting conditions under which such a detector should operate, namely day and night time. Recent research has shown that the combination of visible and non-visible imaging modalities may increase detection accuracy, where the infrared spectrum plays a critical role. The goal of this paper is to assess the accuracy gain of different pedestrian models (holistic, part-based, patch-based) when training with images in the far infrared spectrum. Specifically, we want to compare detection accuracy on test images recorded at day and nighttime if trained (and tested) using (a) plain color images, (b) just infrared images and (c) both of them. In order to obtain results for the last item we propose an early fusion approach to combine features from both modalities. We base the evaluation on a new dataset we have built for this purpose as well as on the publicly available KAIST multispectral dataset.
Keywords: Pedestrian Detection; FIR
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Angel Sappa, P. Carvajal, Cristhian A. Aguilera-Carrasco, Miguel Oliveira, Dennis Romero, & Boris X. Vintimilla. (2016). Wavelet based visible and infrared image fusion: a comparative study. SENS - Sensors, 16(6), 1–15.
Abstract: This paper evaluates different wavelet-based cross-spectral image fusion strategies adopted to merge visible and infrared images. The objective is to find the best setup independently of the evaluation metric used to measure the performance. Quantitative performance results are obtained with state of the art approaches together with adaptations proposed in the current work. The options evaluated in the current work result from the combination of different setups in the wavelet image decomposition stage together with different fusion strategies for the final merging stage that generates the resulting representation. Most of the approaches evaluate results according to the application for which they are intended for. Sometimes a human observer is selected to judge the quality of the obtained results. In the current work, quantitative values are considered in order to find correlations between setups and performance of obtained results; these correlations can be used to define a criteria for selecting the best fusion strategy for a given pair of cross-spectral images. The whole procedure is evaluated with a large set of correctly registered visible and infrared image pairs, including both Near InfraRed (NIR) and Long Wave InfraRed (LWIR).
Keywords: Image fusion; fusion evaluation metrics; visible and infrared imaging; discrete wavelet transform
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Jorge Bernal, Nima Tajkbaksh, F. Javier Sanchez, Bogdan J. Matuszewski, Hao Chen, Lequan Yu, et al. (2017). Comparative Validation of Polyp Detection Methods in Video Colonoscopy: Results from the MICCAI 2015 Endoscopic Vision Challenge. TMI - IEEE Transactions on Medical Imaging, 36(6), 1231–1249.
Abstract: Colonoscopy is the gold standard for colon cancer screening though still some polyps are missed, thus preventing early disease detection and treatment. Several computational systems have been proposed to assist polyp detection during colonoscopy but so far without consistent evaluation. The lack
of publicly available annotated databases has made it difficult to compare methods and to assess if they achieve performance levels acceptable for clinical use. The Automatic Polyp Detection subchallenge, conducted as part of the Endoscopic Vision Challenge (http://endovis.grand-challenge.org) at the international conference on Medical Image Computing and Computer Assisted
Intervention (MICCAI) in 2015, was an effort to address this need. In this paper, we report the results of this comparative evaluation of polyp detection methods, as well as describe additional experiments to further explore differences between methods. We define performance metrics and provide evaluation databases that allow comparison of multiple methodologies. Results show that convolutional neural networks (CNNs) are the state of the art. Nevertheless it is also demonstrated that combining different methodologies can lead to an improved overall performance.
Keywords: Endoscopic vision; Polyp Detection; Handcrafted features; Machine Learning; Validation Framework
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Xinhang Song, Shuqiang Jiang, & Luis Herranz. (2017). Multi-Scale Multi-Feature Context Modeling for Scene Recognition in the Semantic Manifold. TIP - IEEE Transactions on Image Processing, 26(6), 2721–2735.
Abstract: Before the big data era, scene recognition was often approached with two-step inference using localized intermediate representations (objects, topics, and so on). One of such approaches is the semantic manifold (SM), in which patches and images are modeled as points in a semantic probability simplex. Patch models are learned resorting to weak supervision via image labels, which leads to the problem of scene categories co-occurring in this semantic space. Fortunately, each category has its own co-occurrence patterns that are consistent across the images in that category. Thus, discovering and modeling these patterns are critical to improve the recognition performance in this representation. Since the emergence of large data sets, such as ImageNet and Places, these approaches have been relegated in favor of the much more powerful convolutional neural networks (CNNs), which can automatically learn multi-layered representations from the data. In this paper, we address many limitations of the original SM approach and related works. We propose discriminative patch representations using neural networks and further propose a hybrid architecture in which the semantic manifold is built on top of multiscale CNNs. Both representations can be computed significantly faster than the Gaussian mixture models of the original SM. To combine multiple scales, spatial relations, and multiple features, we formulate rich context models using Markov random fields. To solve the optimization problem, we analyze global and local approaches, where a top-down hierarchical algorithm has the best performance. Experimental results show that exploiting different types of contextual relations jointly consistently improves the recognition accuracy.
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Jordi Esquirol, Cristina Palmero, Vanessa Bayo, Miquel Angel Cos, Sergio Escalera, David Sanchez, et al. (2017). Automatic RBG-depth-pressure anthropometric analysis and individualised sleep solution prescription. JMET - Journal of Medical Engineering & Technology, 486–497.
Abstract: INTRODUCTION:
Sleep surfaces must adapt to individual somatotypic features to maintain a comfortable, convenient and healthy sleep, preventing diseases and injuries. Individually determining the most adequate rest surface can often be a complex and subjective question.
OBJECTIVES:
To design and validate an automatic multimodal somatotype determination model to automatically recommend an individually designed mattress-topper-pillow combination.
METHODS:
Design and validation of an automated prescription model for an individualised sleep system is performed through a single-image 2 D-3 D analysis and body pressure distribution, to objectively determine optimal individual sleep surfaces combining five different mattress densities, three different toppers and three cervical pillows.
RESULTS:
A final study (n = 151) and re-analysis (n = 117) defined and validated the model, showing high correlations between calculated and real data (>85% in height and body circumferences, 89.9% in weight, 80.4% in body mass index and more than 70% in morphotype categorisation).
CONCLUSIONS:
Somatotype determination model can accurately prescribe an individualised sleep solution. This can be useful for healthy people and for health centres that need to adapt sleep surfaces to people with special needs. Next steps will increase model's accuracy and analise, if this prescribed individualised sleep solution can improve sleep quantity and quality; additionally, future studies will adapt the model to mattresses with technological improvements, tailor-made production and will define interfaces for people with special needs.
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Marta Diez-Ferrer, Debora Gil, Cristian Tebe, & Carles Sanchez. (2018). Positive Airway Pressure to Enhance Computed Tomography Imaging for Airway Segmentation for Virtual Bronchoscopic Navigation. RES - Respiration, 96(6), 525–534.
Abstract: Abstract
RATIONALE:
Virtual bronchoscopic navigation (VBN) guidance to peripheral pulmonary lesions is often limited by insufficient segmentation of the peripheral airways.
OBJECTIVES:
To test the effect of applying positive airway pressure (PAP) during CT acquisition to improve segmentation, particularly at end-expiration.
METHODS:
CT acquisitions in inspiration and expiration with 4 PAP protocols were recorded prospectively and compared to baseline inspiratory acquisitions in 20 patients. The 4 protocols explored differences between devices (flow vs. turbine), exposures (within seconds vs. 15-min) and pressure levels (10 vs. 14 cmH2O). Segmentation quality was evaluated with the number of airways and number of endpoints reached. A generalized mixed-effects model explored the estimated effect of each protocol.
MEASUREMENTS AND MAIN RESULTS:
Patient characteristics and lung function did not significantly differ between protocols. Compared to baseline inspiratory acquisitions, expiratory acquisitions after 15 min of 14 cmH2O PAP segmented 1.63-fold more airways (95% CI 1.07-2.48; p = 0.018) and reached 1.34-fold more endpoints (95% CI 1.08-1.66; p = 0.004). Inspiratory acquisitions performed immediately under 10 cmH2O PAP reached 1.20-fold (95% CI 1.09-1.33; p < 0.001) more endpoints; after 15 min the increase was 1.14-fold (95% CI 1.05-1.24; p < 0.001).
CONCLUSIONS:
CT acquisitions with PAP segment more airways and reach more endpoints than baseline inspiratory acquisitions. The improvement is particularly evident at end-expiration after 15 min of 14 cmH2O PAP. Further studies must confirm that the improvement increases diagnostic yield when using VBN to evaluate peripheral pulmonary lesions.
Keywords: Multidetector computed tomography; Bronchoscopy; Continuous positive airway pressure; Image enhancement; Virtual bronchoscopic navigation
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Reza Azad, Maryam Asadi-Aghbolaghi, Shohreh Kasaei, & Sergio Escalera. (2019). Dynamic 3D Hand Gesture Recognition by Learning Weighted Depth Motion Maps. TCSVT - IEEE Transactions on Circuits and Systems for Video Technology, 29(6), 1729–1740.
Abstract: Hand gesture recognition from sequences of depth maps is a challenging computer vision task because of the low inter-class and high intra-class variability, different execution rates of each gesture, and the high articulated nature of human hand. In this paper, a multilevel temporal sampling (MTS) method is first proposed that is based on the motion energy of key-frames of depth sequences. As a result, long, middle, and short sequences are generated that contain the relevant gesture information. The MTS results in increasing the intra-class similarity while raising the inter-class dissimilarities. The weighted depth motion map (WDMM) is then proposed to extract the spatio-temporal information from generated summarized sequences by an accumulated weighted absolute difference of consecutive frames. The histogram of gradient (HOG) and local binary pattern (LBP) are exploited to extract features from WDMM. The obtained results define the current state-of-the-art on three public benchmark datasets of: MSR Gesture 3D, SKIG, and MSR Action 3D, for 3D hand gesture recognition. We also achieve competitive results on NTU action dataset.
Keywords: Hand gesture recognition; Multilevel temporal sampling; Weighted depth motion map; Spatio-temporal description; VLAD encoding
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Mikhail Mozerov, & Joost Van de Weijer. (2019). One-view occlusion detection for stereo matching with a fully connected CRF model. TIP - IEEE Transactions on Image Processing, 28(6), 2936–2947.
Abstract: In this paper, we extend the standard belief propagation (BP) sequential technique proposed in the tree-reweighted sequential method [15] to the fully connected CRF models with the geodesic distance affinity. The proposed method has been applied to the stereo matching problem. Also a new approach to the BP marginal solution is proposed that we call one-view occlusion detection (OVOD). In contrast to the standard winner takes all (WTA) estimation, the proposed OVOD solution allows to find occluded regions in the disparity map and simultaneously improve the matching result. As a result we can perform only
one energy minimization process and avoid the cost calculation for the second view and the left-right check procedure. We show that the OVOD approach considerably improves results for cost augmentation and energy minimization techniques in comparison with the standard one-view affinity space implementation. We apply our method to the Middlebury data set and reach state-ofthe-art especially for median, average and mean squared error metrics.
Keywords: Stereo matching; energy minimization; fully connected MRF model; geodesic distance filter
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