Abstract: PURPOSE:
In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior.
METHODS:
A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations.
RESULTS:
Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm.
CONCLUSIONS:
Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results.

Abstract: During the next decade, on-board pedestrian detection systems will play a key role in the challenge of increasing traffic safety. The main target of these systems, to detect pedestrians in urban scenarios, implies overcoming difficulties like processing outdoor scenes from a mobile platform and searching for aspect-changing objects in cluttered environments. This makes such systems combine techniques in the state-of-the-art Computer Vision. In this paper we present a three module system based on both 2D and 3D cues. The first module uses 3D information to estimate the road plane parameters and thus select a coherent set of regions of interest (ROIs) to be further analyzed. The second module uses Real AdaBoost and a combined set of Haar wavelets and edge orientation histograms to classify the incoming ROIs as pedestrian or non-pedestrian. The final module loops again with the 3D cue in order to verify the classified ROIs and with the 2D in order to refine the final results. According to the results, the integration of the proposed techniques gives rise to a promising system.

Abstract: (Editorial for the Special Issue on Online pattern recognition and machine learning techniques)
In real life, visual learning is supposed to be a continuous process. This paradigm has found its way also in artificial vision systems. There is an increasing trend in pattern recognition represented by online learning approaches, which aims at continuously updating the data representation when new information arrives. Starting with a minimal dataset, the initial knowledge is expanded by incorporating incoming instances, which may have not been previously available or foreseen at the system’s design stage. An interesting characteristic of this strategy is that the train and test phases take place simultaneously. Given the increasing interest in this subject, the aim of this special issue is to be a landmark event in the development of online learning techniques and their applications with the hope that it will capture the interest of a wider audience and will attract even more researchers. We received 19 contributions, of which 9 have been accepted for publication, after having been subjected to usual peer review process.

Abstract: A standard way to deal with multi-class categorization problems is by the combination of binary classifiers in a pairwise voting procedure. Recently, this classical approach has been formalized in the Error-Correcting Output Codes (ECOC) framework. In the ECOC framework, the one-versus-one coding demonstrates to achieve higher performance than the rest of coding designs. The binary problems that we train in the one-versus-one strategy are significantly smaller than in the rest of designs, and usually easier to be learnt, taking into account the smaller overlapping between classes. However, a high percentage of the positions coded by zero of the coding matrix, which implies a high sparseness degree, does not codify meta-class membership information. In this paper, we show that using the training data we can redefine without re-training, in a problem-dependent way, the one-versus-one coding matrix so that the new coded information helps the system to increase its generalization capability. Moreover, the new re-coding strategy is generalized to be applied over any binary code. The results over several UCI Machine Learning repository data sets and two real multi-class problems show that performance improvements can be obtained re-coding the classical one-versus-one and Sparse random designs compared to different state-of-the-art ECOC configurations.

Abstract: Distortion of Left Ventricle (LV) external anatomy is related to some dysfunctions, such as hypertrophy. The architecture of myocardial fibers determines LV electromechanical activation patterns as well as mechanics. Thus, their joined modelling would allow the design of specific interventions (such as peacemaker implantation and LV remodelling) and therapies (such as resynchronization). On one hand, accurate modelling of external anatomy requires either a dense sampling or a continuous infinite dimensional approach, which requires non-Euclidean statistics. On the other hand, computation of fiber models requires statistics on Riemannian spaces. Most approaches compute separate statistical models for external anatomy and fibers architecture. In this work we propose a general mathematical framework based on differential geometry concepts for computing a statistical model including, both, external and fiber anatomy. Our framework provides a continuous approach to external anatomy supporting standard statistics. We also provide a straightforward formula for the computation of the Riemannian fiber statistics. We have applied our methodology to the computation of complete anatomical atlas of canine hearts from diffusion tensor studies. The orientation of fibers over the average external geometry agrees with the segmental description of orientations reported in the literature.

Abstract: Speckle noise negatively affects medical ultrasound image shape interpretation and boundary detection. Speckle removal filters are widely used to selectively remove speckle noise without destroying important image features to enhance object boundaries. In this article, a fully automatic bilateral filter tailored to ultrasound images is proposed. The edge preservation property is obtained by embedding noise statistics in the filter framework. Consequently, the filter is able to tackle the multiplicative behavior modulating the smoothing strength with respect to local statistics. The in silico experiments clearly showed that the speckle reducing bilateral filter (SRBF) has superior performances to most of the state of the art filtering methods. The filter is tested on 50 in vivo US images and its influence on a segmentation task is quantified. The results using SRBF filtered data sets show a superior performance to using oriented anisotropic diffusion filtered images. This improvement is due to the adaptive support of SRBF and the embedded noise statistics, yielding a more homogeneous smoothing. SRBF results in a fully automatic, fast and flexible algorithm potentially suitable in wide ranges of speckle noise sizes, for different medical applications (IVUS, B-mode, 3-D matrix array US).

Abstract: The trend to use large amounts of simple sensors as opposed to a few complex sensors to monitor places and systems creates a need for temporal pattern mining algorithms to work on such data. The methods that try to discover re-usable and interpretable patterns in temporal event data have several shortcomings. We contrast several recent approaches to the problem, and extend the T-Pattern algorithm, which was previously applied for detection of sequential patterns in behavioural sciences. The temporal complexity of the T-pattern approach is prohibitive in the scenarios we consider. We remedy this with a statistical model to obtain a fast and robust algorithm to find patterns in temporal data. We test our algorithm on a recent database collected with passive infrared sensors with millions of events.