Abstract: Human visual perception is limited to the visual-optical spectrum. Machine vision is not. Cameras sensitive to the different infrared spectra can enhance the abilities of autonomous systems and visually perceive the environment in a holistic way. Relevant scene content can be made visible especially in situations, where sensors of other modalities face issues like a visual-optical camera that needs a source of illumination. As a consequence, not only human mistakes can be avoided by increasing the level of automation, but also machine-induced errors can be reduced that, for example, could make a self-driving car crash into a pedestrian under difficult illumination conditions. Furthermore, multi-spectral sensor systems with infrared imagery as one modality are a rich source of information and can provably increase the robustness of many autonomous systems. Applications that can benefit from utilizing infrared imagery range from robotics to automotive and from biometrics to surveillance. In this book, we provide a brief yet concise introduction to the current state-of-the-art of computer vision and machine learning in the infrared spectrum. Based on various popular computer vision tasks such as image enhancement, object detection, or object tracking, we first motivate each task starting from established literature in the visual-optical spectrum. Then, we discuss the differences between processing images and videos in the visual-optical spectrum and the various infrared spectra. An overview of the current literature is provided together with an outlook for each task. Furthermore, available and annotated public datasets and common evaluation methods and metrics are presented. In a separate chapter, popular applications that can greatly benefit from the use of infrared imagery as a data source are presented and discussed. Among them are automatic target recognition, video surveillance, or biometrics including face recognition. Finally, we conclude with recommendations for well-fitting sensor setups and data processing algorithms for certain computer vision tasks. We address this book to prospective researchers and engineers new to the field but also to anyone who wants to get introduced to the challenges and the approaches of computer vision using infrared images or videos. Readers will be able to start their work directly after reading the book supported by a highly comprehensive backlog of recent and relevant literature as well as related infrared datasets including existing evaluation frameworks. Together with consistently decreasing costs for infrared cameras, new fields of application appear and make computer vision in the infrared spectrum a great opportunity to face nowadays scientific and engineering challenges.

Abstract: The emergence of deep learning has considerably advanced the state-of-the-art in cardiac magnetic resonance (CMR) segmentation. Many techniques have been proposed over the last few years, bringing the accuracy of automated segmentation close to human performance. However, these models have been all too often trained and validated using cardiac imaging samples from single clinical centres or homogeneous imaging protocols. This has prevented the development and validation of models that are generalizable across different clinical centres, imaging conditions or scanner vendors. To promote further research and scientific benchmarking in the field of generalizable deep learning for cardiac segmentation, this paper presents the results of the Multi-Centre, Multi-Vendor and Multi-Disease Cardiac Segmentation (M&Ms) Challenge, which was recently organized as part of the MICCAI 2020 Conference. A total of 14 teams submitted different solutions to the problem, combining various baseline models, data augmentation strategies, and domain adaptation techniques. The obtained results indicate the importance of intensity-driven data augmentation, as well as the need for further research to improve generalizability towards unseen scanner vendors or new imaging protocols. Furthermore, we present a new resource of 375 heterogeneous CMR datasets acquired by using four different scanner vendors in six hospitals and three different countries (Spain, Canada and Germany), which we provide as open-access for the community to enable future research in the field.

Abstract: Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue.

Abstract: Word spotting can be defined as the pattern recognition tasked aimed at locating and retrieving a specific keyword within a document image collection without explicitly transcribing the whole corpus. Its use is particularly interesting when applied in scenarios where Optical Character Recognition performs poorly or can not be used at all. This thesis focuses on such a scenario, word spotting on historical handwritten documents that have been written by a single author or by multiple authors with a similar calligraphy.
This problem requires a visual signature that is robust to image artifacts, flexible to accommodate script variations and efficient to retrieve information in a rapid manner. For this, we have developed a set of word spotting methods that on their foundation use the well known Bag-of-Visual-Words (BoVW) representation. This representation has gained popularity among the document image analysis community to characterize handwritten words
in an unsupervised manner. However, most approaches on this field rely on a basic BoVW configuration and disregard complex encoding and spatial representations. We determine which BoVW configurations provide the best performance boost to a spotting system.
Then, we extend the segmentation-based word spotting, where word candidates are given a priori, to segmentation-free spotting. The proposed approach seeds the document images with overlapping word location candidates and characterizes them with a BoVW signature. Retrieval is achieved comparing the query and candidate signatures and returning the locations that provide a higher consensus. This is a simple but powerful approach that requires a more compact signature than in a segmentation-based scenario. We first
project the BoVW signature into a reduced semantic topics space and then compress it further using Product Quantizers. The resulting signature only requires a few dozen bytes, allowing us to index thousands of pages on a common desktop computer. The final system still yields a performance comparable to the state-of-the-art despite all the information loss during the compression phases.
Afterwards, we also study how to combine different modalities of information in order to create a query-by-X spotting system where, words are indexed using an information modality and queries are retrieved using another. We consider three different information modalities: visual, textual and audio. Our proposal is to create a latent feature space where features which are semantically related are projected onto the same topics. Creating thus a new feature space where information from different modalities can be compared. Later, we consider the codebook generation and descriptor encoding problem. The codebooks used to encode the BoVW signatures are usually created using an unsupervised clustering algorithm and, they require to test multiple parameters to determine which configuration is best for a certain document collection. We propose a semantic clustering algorithm which allows to estimate the best parameter from data. Since gather annotated data is costly, we use synthetically generated word images. The resulting codebook is database agnostic, i. e. a codebook that yields a good performance on document collections that use the same script. We also propose the use of an additional codebook to approximate descriptors and reduce the descriptor encoding
complexity to sub-linear.
Finally, we focus on the problem of signatures dimensionality. We propose a new symbol probability signature where each bin represents the probability that a certain symbol is present a certain location of the word image. This signature is extremely compact and combined with compression techniques can represent word images with just a few bytes per signature.

Abstract: The most common tool for population-wide COVID-19 identification is the Reverse Transcription-Polymerase Chain Reaction test that detects the presence of the virus in the throat (or sputum) in swab samples. This test has a sensitivity between 59% and 71%. However, this test does not provide precise information regarding the extension of the pulmonary infection. Moreover, it has been proven that through the reading of a computed tomography (CT) scan, a clinician can provide a more complete perspective of the severity of the disease. Therefore, we propose a comprehensive system for fully-automated COVID-19 detection and lesion segmentation from CT scans, powered by deep learning strategies to support decision-making process for the diagnosis of COVID-19.

Abstract: Super-resolution (SR) has achieved great success due to the development of deep convolutional neural networks (CNNs). However, as the depth and width of the networks increase, CNN-based SR methods have been faced with the challenge of computational complexity in practice. More- over, most SR methods train a dedicated model for each target resolution, losing generality and increasing memory requirements. To address these limitations we introduce OverNet, a deep but lightweight convolutional network to solve SISR at arbitrary scale factors with a single model. We make the following contributions: first, we introduce a lightweight feature extractor that enforces efficient reuse of information through a novel recursive structure of skip and dense connections. Second, to maximize the performance of the feature extractor, we propose a model agnostic reconstruction module that generates accurate high-resolution images from overscaled feature maps obtained from any SR architecture. Third, we introduce a multi-scale loss function to achieve generalization across scales. Experiments show that our proposal outperforms previous state-of-the-art approaches in standard benchmarks, while maintaining relatively low computation and memory requirements.

Abstract: Images with visual and scene text content are ubiquitous in everyday life. However, current image interpretation systems are mostly limited to using only the visual features, neglecting to leverage the scene text content. In this paper, we propose to jointly use scene text and visual channels for robust semantic interpretation of images. We do not only extract and encode visual and scene text cues, but also model their interplay to generate a contextual joint embedding with richer semantics. The contextual embedding thus generated is applied to retrieval and classification tasks on multimedia images, with scene text content, to demonstrate its effectiveness. In the retrieval framework, we augment our learned text-visual semantic representation with scene text cues, to mitigate vocabulary misses that may have occurred during the semantic embedding. To deal with irrelevant or erroneous recognition of scene text, we also apply query-based attention to our text channel. We show how the multi-channel approach, involving visual semantics and scene text, improves upon state of the art.