Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.

Abstract: Most document analysis applications rely on the extraction of shape descriptors, which may be grouped into different categories, each category having its own advantages and drawbacks (O.R. Terrades et al. in Proceedings of ICDAR’07, pp. 227–231, 2007). In order to improve the richness of their description, many authors choose to combine multiple descriptors. Yet, most of the authors who propose a new descriptor content themselves with comparing its performance to the performance of a set of single state-of-the-art descriptors in a specific applicative context (e.g. symbol recognition, symbol spotting...). This results in a proliferation of the shape descriptors proposed in the literature. In this article, we propose an innovative protocol, the originality of which is to be as independent of the final application as possible and which relies on new quantitative and qualitative measures. We introduce two types of measures: while the measures of the first type are intended to characterize the descriptive power (in terms of uniqueness, distinctiveness and robustness towards noise) of a descriptor, the second type of measures characterizes the complementarity between multiple descriptors. Characterizing upstream the complementarity of shape descriptors is an alternative to the usual approach where the descriptors to be combined are selected by trial and error, considering the performance characteristics of the overall system. To illustrate the contribution of this protocol, we performed experimental studies using a set of descriptors and a set of symbols which are widely used by the community namely ART and SC descriptors and the GREC 2003 database.

Abstract: Several studies have recorded color emotions in subjects viewing uniform color (UC) samples. We conduct an experiment to measure and model how these color emotions change when texture is added to the color samples. Using a computer monitor, our subjects arrange samples along four scales: warm–cool, masculine–feminine, hard–soft, and heavy–light. Three sample types of increasing visual complexity are used: UC, grayscale textures, and color textures (CTs). To assess the intraobserver variability, the experiment is repeated after 1 week. Our results show that texture fully determines the responses on the Hard-Soft scale, and plays a role of decreasing weight for the masculine–feminine, heavy–light, and warm–cool scales. Using some 25,000 observer responses, we derive color emotion functions that predict the group-averaged scale responses from the samples' color and texture parameters. For UC samples, the accuracy of our functions is significantly higher (average R2 = 0.88) than that of previously reported functions applied to our data. The functions derived for CT samples have an accuracy of R2 = 0.80. We conclude that when textured samples are used in color emotion studies, the psychological responses may be strongly affected by texture. © 2010 Wiley Periodicals, Inc. Col Res Appl, 2010

Abstract: of a railway supply line when the supply line is in contact with a head of a pantograph of a vehicle in order to power said vehicle . The device includes a camera ( for monitoring parameters indicative of operating capability of said supply line.
The device is intended to monitor condition
tive of operating capability of said supply line. The device includes a reflective element. comprising a pattern , intended to be arranged onto the pantograph head . The camera is intended to be arranged on the vehicle (10) so as to register the pattern position regarding a vertical direction.

Abstract: PATREC5825
We present a methodology to address the problem of human gesture segmentation and recognition in video and depth image sequences. A Bag-of-Visual-and-Depth-Words (BoVDW) model is introduced as an extension of the Bag-of-Visual-Words (BoVW) model. State-of-the-art RGB and depth features, including a newly proposed depth descriptor, are analysed and combined in a late fusion form. The method is integrated in a Human Gesture Recognition pipeline, together with a novel probability-based Dynamic Time Warping (PDTW) algorithm which is used to perform prior segmentation of idle gestures. The proposed DTW variant uses samples of the same gesture category to build a Gaussian Mixture Model driven probabilistic model of that gesture class. Results of the whole Human Gesture Recognition pipeline in a public data set show better performance in comparison to both standard BoVW model and DTW approach.

Abstract: Non-rigid object detection is a challenging an open research problem in computer vision. It is a critical part in many applications such as image search, surveillance, human-computer interaction or image auto-annotation. Most successful approaches to non-rigid object detection make use of part-based models. In particular, Conditional Random Fields (CRF) have been successfully embedded into a discriminative parts-based model framework due to its effectiveness for learning and inference (usually based on a tree structure). However, CRF-based approaches do not incorporate global constraints and only model pairwise interactions. This is especially important when modeling object classes that may have complex parts interactions (e.g. facial features or body articulations), because neglecting them yields an oversimplified model with suboptimal performance. To overcome this limitation, this paper proposes a novel hierarchical CRF (HCRF). The main contribution is to build a hierarchy of part combinations by extending the label set to a hierarchy of product label spaces. In order to keep the inference computation tractable, we propose an effective method to reduce the new label set. We test our method on two applications: facial feature detection on the Multi-PIE database and human pose estimation on the Buffy dataset.

Abstract: We describe a novel technique for feature combination in the bag-of-words model of image classification. Our approach builds discriminative compound words from primitive cues learned independently from training images. Our main observation is that modeling joint-cue distributions independently is more statistically robust for typical classification problems than attempting to empirically estimate the dependent, joint-cue distribution directly. We use Information theoretic vocabulary compression to find discriminative combinations of cues and the resulting vocabulary of portmanteau words is compact, has the cue binding property, and supports individual weighting of cues in the final image representation. State-of-the-art results on both the Oxford Flower-102 and Caltech-UCSD Bird-200 datasets demonstrate the effectiveness of our technique compared to other, significantly more complex approaches to multi-cue image representation

Abstract: The visual system perceives the colour of surfaces approximately constant under changes of illumination. In this work, we investigate how stable is the perception of categorical \“focal\” colours and their interrelations with varying illuminants and simple chromatic backgrounds. It has been proposed that best examples of colour categories across languages cluster in small regions of the colour space and are restricted to a set of 11 basic terms (Kay and Regier, 2003 Proceedings of the National Academy of Sciences of the USA 100 9085\–9089). Following this, we developed a psychophysical paradigm that exploits the ability of subjects to reliably reproduce the most representative examples of each category, adjusting multiple test patches embedded in a coloured Mondrian. The experiment was run on a CRT monitor (inside a dark room) under various simulated illuminants. We modelled the recorded data for each subject and adapted state as a 3D interconnected structure (graph) in Lab space. The graph nodes were the subject\’s focal colours at each adaptation state. The model allowed us to get a better distance measure between focal structures under different illuminants. We found that perceptual focal structures tend to be preserved better than the structures of the physical \“ideal\” colours under illuminant changes.