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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism,			Type	Journal Article
	Year	2013	Publication	Drug Discovery Today	Abbreviated Journal	DDT
	Volume	18	Issue	7-8	Pages	365-371
	Keywords
	Abstract	The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.
	Address
	Corporate Author				Thesis
	Publisher	Elsevier	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 600.057; 600.054			Approved	no
	Call Number	IAM @ iam @ RGG2013a			Serial	2190
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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models			Type	Journal Article
	Year	2013	Publication	British Journal of Pharmacology	Abbreviated Journal	BJP
	Volume	169	Issue	6	Pages	1189-202
	Keywords
	Abstract	Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 600.044; 605.203			Approved	no
	Call Number	IAM @ iam @ RGG2013b			Serial	2195
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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models?			Type	Book Chapter
	Year	2014	Publication	G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology	Abbreviated Journal
	Volume	796	Issue	3	Pages	159-181
	Keywords	β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
	Abstract	Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
	Address
	Corporate Author				Thesis
	Publisher	Springer Netherlands	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0065-2598	ISBN	978-94-007-7422-3	Medium
	Area		Expedition		Conference
	Notes	IAM; 600.075			Approved	no
	Call Number	IAM @ iam @ RGG2014			Serial	2197
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	Author	David Rotger
	Title	Multimodal Registration of Intravascular Ultrasound Images and Angiography			Type	Miscellaneous
	Year	2002	Publication	Director: P. Radeva, Master Thesis.	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	Admin @ si @ Rot2002			Serial	324
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	Author	David Rotger
	Title	Analysis and Multi-Modal Fusion of coronary Images			Type	Book Whole
	Year	2009	Publication	PhD Thesis, Universitat Autonoma de Barcelona-CVC	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract	The framework of this thesis is to study in detail different techniques and tools for medical image registration in order to ease the daily life of clinical experts in cardiology. The first aim of this thesis is providing computer tools for fusing IVUS and angiogram data is of high clinical interest to help the physicians locate in IVUS data and decide which lesion is observed, how long it is, how far from a bifurcation or another lesions stays, etc. This thesis proves and validates that we can segment the catheter path in angiographies using geodesic snakes (based on fast marching algorithm), a three-dimensional reconstruction of the catheter inspired in stereo vision and a new technique to fuse IVUS and angiograms that establishes exact correspondences between them. We have developed a new workstation called iFusion that has four strong advantages: registration of IVUS and angiographic images with sub-pixel precision, it works on- and off-line, it is independent on the X-ray system and there is no need of daily calibration. The second aim of the thesis is devoted to developing a computer-aided analysis of IVUS for image-guided intervention. We have designed, implemented and validated a robust algorithm for stent extraction and reconstruction from IVUS videos. We consider a very special and recent kind of stents, bioabsorbable stents that represent a great clinical challenge due to their property to be absorbed by time and thus avoiding the “danger” of neostenosis as one of the main problems of metallic stents. We present a new and very promising algorithm based on an optimized cascade of multiple classifiers to automatically detect individual stent struts of a very novel bioabsorbable drug eluting coronary stent. This problem represents a very challenging target given the variability in contrast, shape and grey levels of the regions to be detected, what is denoted by the high variability between the specialists (inter-observer variability of 0.14~$\pm$0.12). The obtained results of the automatic strut detection are within the inter-observer variability.
	Address	Barcelona (Espanya)
	Corporate Author				Thesis	Ph.D. thesis
	Publisher	Ediciones Graficas Rey	Place of Publication		Editor	Petia Radeva
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	Admin @ si @ Rot2009			Serial	1261
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	Author	David Rotger; Cristina Cañero; Petia Radeva; J. Mauri; E. Fernandez; A. Tovar; V. Valle
	Title	3D Interactive Visualization and Volumetric Measurements of Coronary Vessels in IVUS.			Type	Miscellaneous
	Year	2001	Publication	Proceedings of the IX Spanish Symposium on Pattern Recognition and Image Analysis, 1:151–156.	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RCR2001a			Serial	156
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	Author	David Rotger; Cristina Cañero; Petia Radeva; J. Mauri; E. Fernandez; A. Tovar; V. Valle
	Title	Advanced Visualization of 3D data of Intravascular Ultrasound Images.			Type	Miscellaneous
	Year	2001	Publication	Medical Data Analysis, Second International Symposium, ISMDA 2001, 245–250.	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RCR2001b			Serial	157
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	Author	David Rotger; Misael Rosales; Jaume Garcia; Oriol Pujol ; Josefina Mauri; Petia Radeva
	Title	Active Vessel: A New Multimedia Workstation for Intravascular Ultrasound and Angiography Fusion			Type	Journal Article
	Year	2003	Publication	Computers in Cardiology	Abbreviated Journal
	Volume	30	Issue		Pages	65-68
	Keywords
	Abstract	AcriveVessel is a new multimedia workstation which enables the visualization, acquisition and handling of both image modalities, on- and ofline. It enables DICOM v3.0 decompression and browsing, video acquisition,repmduction and storage for IntraVascular UltraSound (IVUS) and angiograms with their corresponding ECG,automatic catheter segmentation in angiography images (using fast marching algorithm). BSpline models definition for vessel layers on IVUS images sequence and an extensively validated tool to fuse information. This approach defines the correspondence of every IVUS image with its correspondent point in the angiogram and viceversa. The 3 0 reconstruction of the NUS catheterhessel enables real distance measurements as well as threedimensional visualization showing vessel tortuosity in the space.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM;MILAB;HuPBA			Approved	no
	Call Number	IAM @ iam @ RRG2003			Serial	1647
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	Author	David Rotger; Petia Radeva; Cristina Cañero; Juan J. Villanueva; J. Mauri; E Fernandez-Nofrerias; A. Tovar; V. Valle
	Title	Corresponding IVUS and Angiogram Image Data			Type	Miscellaneous
	Year	2001	Publication	Proceedings of Computers in Cardiology Rottherdam, (in press).	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address	The Netherlands
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRC2001			Serial	159
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	Author	David Rotger; Petia Radeva; E Fernandez-Nofrerias; J. Mauri
	Title	Registering External and Internal Morphological Images of Coronary Vessels.			Type	Miscellaneous
	Year	2002	Publication	IASTED International Conference Signals Processing, Pattern Recognition and Applications SPPRA.	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRF2002a			Serial	297
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	Author	David Rotger; Petia Radeva; E Fernandez-Nofrerias; J. Mauri
	Title	Multimodal Registration of Intravascular Ultrasound Images and Angiography.			Type	Miscellaneous
	Year	2002	Publication	XX Congreso Anual de la Sociedad Española de Ingenieria Biomedica CASEIB 2002, 1: 137–140.	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address	Zaragoza, Espanya
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRF2002b			Serial	317
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	Author	David Rotger; Petia Radeva; E Fernandez-Nofrerias; J. Mauri
	Title	Blood Detection In IVUS Longitudinal Cuts Using AdaBoost With a Novel Feature Stability Criterion			Type	Conference Article
	Year	2007	Publication	Artificial Intelligence Research and Development. Proceedings of the 10th International Conference of the ACIA	Abbreviated Journal
	Volume	163	Issue		Pages	197–204
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-1-58603-798-7	Medium
	Area		Expedition		Conference	CCIA’07
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRF2007a			Serial	831
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	Author	David Rotger; Petia Radeva; E Fernandez-Nofrerias; J. Mauri
	Title	Blood Detection in IVUS Images for 3D Volume of Lumen Changes Measurement Due to Different Drugs Administration			Type	Conference Article
	Year	2007	Publication	Computer Analysis of Images and Patterns, 12th International Conference	Abbreviated Journal
	Volume	4673	Issue		Pages	285–292
	Keywords
	Abstract
	Address	Vienna (Austria)
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-3-540-74271-5	Medium
	Area		Expedition		Conference	CAIP
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRF2007b			Serial	832
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	Author	David Rotger; Petia Radeva; J. Mauri; E Fernandez-Nofrerias
	Title	Internal and External Coronary Vessel Images Registration.			Type	Miscellaneous
	Year	2002	Publication		Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRM2002b			Serial	318
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	Author	David Rotger; Petia Radeva; N. Bruining
	Title	Automatic Detection of Bioabsorbable Coronary Stents in IVUS Images using a Cascade of Classifiers			Type	Journal Article
	Year	2010	Publication	IEEE Transactions on Information Technology in Biomedicine	Abbreviated Journal	TITB
	Volume	14	Issue	2	Pages	535 – 537
	Keywords
	Abstract	Bioabsorbable drug-eluting coronary stents present a very promising improvement to the common metallic ones solving some of the most important problems of stent implantation: the late restenosis. These stents made of poly-L-lactic acid cause a very subtle acoustic shadow (compared to the metallic ones) making difficult the automatic detection and measurements in images. In this paper, we propose a novel approach based on a cascade of GentleBoost classifiers to detect the stent struts using structural features to code the information of the different subregions of the struts. A stochastic gradient descent method is applied to optimize the overall performance of the detector. Validation results of struts detection are very encouraging with an average F-measure of 81%.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	MILAB			Approved	no
	Call Number	BCNPCL @ bcnpcl @ RRB2010			Serial	1287
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