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Smriti Joshi, Richard Osuala, Carlos Martin-Isla, Victor M.Campello, Carla Sendra-Balcells, Karim Lekadir, et al. (2022). nn-UNet Training on CycleGAN-Translated Images for Cross-modal Domain Adaptation in Biomedical Imaging. In International MICCAI Brainlesion Workshop (Vol. 12963, 540–551). LNCS.
Abstract: In recent years, deep learning models have considerably advanced the performance of segmentation tasks on Brain Magnetic Resonance Imaging (MRI). However, these models show a considerable performance drop when they are evaluated on unseen data from a different distribution. Since annotation is often a hard and costly task requiring expert supervision, it is necessary to develop ways in which existing models can be adapted to the unseen domains without any additional labelled information. In this work, we explore one such technique which extends the CycleGAN [2] architecture to generate label-preserving data in the target domain. The synthetic target domain data is used to train the nn-UNet [3] framework for the task of multi-label segmentation. The experiments are conducted and evaluated on the dataset [1] provided in the ‘Cross-Modality Domain Adaptation for Medical Image Segmentation’ challenge [23] for segmentation of vestibular schwannoma (VS) tumour and cochlea on contrast enhanced (ceT1) and high resolution (hrT2) MRI scans. In the proposed approach, our model obtains dice scores (DSC) 0.73 and 0.49 for tumour and cochlea respectively on the validation set of the dataset. This indicates the applicability of the proposed technique to real-world problems where data may be obtained by different acquisition protocols as in [1] where hrT2 images are more reliable, safer, and lower-cost alternative to ceT1.
Keywords: Domain adaptation; Vestibular schwannoma (VS); Deep learning; nn-UNet; CycleGAN
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Siyang Song, Micol Spitale, Cheng Luo, German Barquero, Cristina Palmero, Sergio Escalera, et al. (2023). REACT2023: The First Multiple Appropriate Facial Reaction Generation Challenge. In Proceedings of the 31st ACM International Conference on Multimedia (9620–9624).
Abstract: The Multiple Appropriate Facial Reaction Generation Challenge (REACT2023) is the first competition event focused on evaluating multimedia processing and machine learning techniques for generating human-appropriate facial reactions in various dyadic interaction scenarios, with all participants competing strictly under the same conditions. The goal of the challenge is to provide the first benchmark test set for multi-modal information processing and to foster collaboration among the audio, visual, and audio-visual behaviour analysis and behaviour generation (a.k.a generative AI) communities, to compare the relative merits of the approaches to automatic appropriate facial reaction generation under different spontaneous dyadic interaction conditions. This paper presents: (i) the novelties, contributions and guidelines of the REACT2023 challenge; (ii) the dataset utilized in the challenge; and (iii) the performance of the baseline systems on the two proposed sub-challenges: Offline Multiple Appropriate Facial Reaction Generation and Online Multiple Appropriate Facial Reaction Generation, respectively. The challenge baseline code is publicly available at https://github.com/reactmultimodalchallenge/baseline_react2023.
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Simone Zini, Alex Gomez-Villa, Marco Buzzelli, Bartlomiej Twardowski, Andrew D. Bagdanov, & Joost Van de Weijer. (2023). Planckian Jitter: countering the color-crippling effects of color jitter on self-supervised training. In 11th International Conference on Learning Representations.
Abstract: Several recent works on self-supervised learning are trained by mapping different augmentations of the same image to the same feature representation. The data augmentations used are of crucial importance to the quality of learned feature representations. In this paper, we analyze how the color jitter traditionally used in data augmentation negatively impacts the quality of the color features in learned feature representations. To address this problem, we propose a more realistic, physics-based color data augmentation – which we call Planckian Jitter – that creates realistic variations in chromaticity and produces a model robust to illumination changes that can be commonly observed in real life, while maintaining the ability to discriminate image content based on color information. Experiments confirm that such a representation is complementary to the representations learned with the currently-used color jitter augmentation and that a simple concatenation leads to significant performance gains on a wide range of downstream datasets. In addition, we present a color sensitivity analysis that documents the impact of different training methods on model neurons and shows that the performance of the learned features is robust with respect to illuminant variations.
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Simone Balocco, O. Camara, E. Vivas, T. Sola, L. Guimaraens, H. A. van Andel, et al. (2010). Feasibility of Estimating Regional Mechanical Properties of Cerebral Aneurysms In Vivo. MEDPHYS - Medical Physics, 37(4), 1689–1706.
Abstract: PURPOSE:
In this article, the authors studied the feasibility of estimating regional mechanical properties in cerebral aneurysms, integrating information extracted from imaging and physiological data with generic computational models of the arterial wall behavior.
METHODS:
A data assimilation framework was developed to incorporate patient-specific geometries into a given biomechanical model, whereas wall motion estimates were obtained from applying registration techniques to a pair of simulated MR images and guided the mechanical parameter estimation. A simple incompressible linear and isotropic Hookean model coupled with computational fluid-dynamics was employed as a first approximation for computational purposes. Additionally, an automatic clustering technique was developed to reduce the number of parameters to assimilate at the optimization stage and it considerably accelerated the convergence of the simulations. Several in silico experiments were designed to assess the influence of aneurysm geometrical characteristics and the accuracy of wall motion estimates on the mechanical property estimates. Hence, the proposed methodology was applied to six real cerebral aneurysms and tested against a varying number of regions with different elasticity, different mesh discretization, imaging resolution, and registration configurations.
RESULTS:
Several in silico experiments were conducted to investigate the feasibility of the proposed workflow, results found suggesting that the estimation of the mechanical properties was mainly influenced by the image spatial resolution and the chosen registration configuration. According to the in silico experiments, the minimal spatial resolution needed to extract wall pulsation measurements with enough accuracy to guide the proposed data assimilation framework was of 0.1 mm.
CONCLUSIONS:
Current routine imaging modalities do not have such a high spatial resolution and therefore the proposed data assimilation framework cannot currently be used on in vivo data to reliably estimate regional properties in cerebral aneurysms. Besides, it was observed that the incorporation of fluid-structure interaction in a biomechanical model with linear and isotropic material properties did not have a substantial influence in the final results.
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Simone Balocco, O. Basset, G. Courbebaisse, E. Boni, Alejandro F. Frangi, P. Tortoli, et al. (2010). Estimation Of Viscoelastic Properties Of Vessel Walls Using a Computational Model and Doppler Ultrasound. PMB - Physics in Medicine and Biology, 55(12), 3557–3575.
Abstract: Human arteries affected by atherosclerosis are characterized by altered wall viscoelastic properties. The possibility of noninvasively assessing arterial viscoelasticity in vivo would significantly contribute to the early diagnosis and prevention of this disease. This paper presents a noniterative technique to estimate the viscoelastic parameters of a vascular wall Zener model. The approach requires the simultaneous measurement of flow variations and wall displacements, which can be provided by suitable ultrasound Doppler instruments. Viscoelastic parameters are estimated by fitting the theoretical constitutive equations to the experimental measurements using an ARMA parameter approach. The accuracy and sensitivity of the proposed method are tested using reference data generated by numerical simulations of arterial pulsation in which the physiological conditions and the viscoelastic parameters of the model can be suitably varied. The estimated values quantitatively agree with the reference values, showing that the only parameter affected by changing the physiological conditions is viscosity, whose relative error was about 27% even when a poor signal-to-noise ratio is simulated. Finally, the feasibility of the method is illustrated through three measurements made at different flow regimes on a cylindrical vessel phantom, yielding a parameter mean estimation error of 25%.
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Simone Balocco, Mauricio Gonzalez, Ricardo Ñancule, Petia Radeva, & Gabriel Thomas. (2018). Calcified Plaque Detection in IVUS Sequences: Preliminary Results Using Convolutional Nets. In International Workshop on Artificial Intelligence and Pattern Recognition (Vol. 11047, pp. 34–42). LNCS.
Abstract: The manual inspection of intravascular ultrasound (IVUS) images to detect clinically relevant patterns is a difficult and laborious task performed routinely by physicians. In this paper, we present a framework based on convolutional nets for the quick selection of IVUS frames containing arterial calcification, a pattern whose detection plays a vital role in the diagnosis of atherosclerosis. Preliminary experiments on a dataset acquired from eighty patients show that convolutional architectures improve detections of a shallow classifier in terms of 𝐹1-measure, precision and recall.
Keywords: Intravascular ultrasound images; Convolutional nets; Deep learning; Medical image analysis
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Simone Balocco, Maria Zuluaga, Guillaume Zahnd, Su-Lin Lee, & Stefanie Demirci. (2016). Computing and Visualization for Intravascular Imaging and Computer Assisted Stenting. Elsevier.
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Simone Balocco, Francesco Ciompi, Juan Rigla, Xavier Carrillo, J. Mauri, & Petia Radeva. (2017). Intra-Coronary Stent localization In Intravascular Ultrasound Sequences, A Preliminary Study. In International workshop on Computing and Visualization for Intravascular Imaging and Computer Assisted Stenting (CVII-STENT). LNCS.
Abstract: An intraluminal coronary stent is a metal scaold deployed in a stenotic artery during Percutaneous Coronary Intervention (PCI).
Intravascular Ultrasound (IVUS) is a catheter-based imaging technique generally used for assessing the correct placement of the stent. All the approaches proposed so far for the stent analysis only focused on the struts detection, while this paper proposes a novel approach to detect the boundaries and the position of the stent along the pullback.
The pipeline of the method requires the identi cation of the stable frames
of the sequence and the reliable detection of stent struts. Using this data,
a measure of likelihood for a frame to contain a stent is computed. Then,
a robust binary representation of the presence of the stent in the pullback
is obtained applying an iterative and multi-scale approximation of the signal to symbols using the SAX algorithm. Results obtained comparing the automatic results versus the manual annotation of two observers on 80 IVUS in-vivo sequences shows that the method approaches the inter-observer variability scores.
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Simone Balocco, Francesco Ciompi, Juan Rigla, Xavier Carrillo, J. Mauri, & Petia Radeva. (2019). Assessment of intracoronary stent location and extension in intravascular ultrasound sequences. MEDPHYS - Medical Physics, 46(2), 484–493.
Abstract: PURPOSE:
An intraluminal coronary stent is a metal scaffold deployed in a stenotic artery during percutaneous coronary intervention (PCI). In order to have an effective deployment, a stent should be optimally placed with regard to anatomical structures such as bifurcations and stenoses. Intravascular ultrasound (IVUS) is a catheter-based imaging technique generally used for PCI guiding and assessing the correct placement of the stent. A novel approach that automatically detects the boundaries and the position of the stent along the IVUS pullback is presented. Such a technique aims at optimizing the stent deployment.
METHODS:
The method requires the identification of the stable frames of the sequence and the reliable detection of stent struts. Using these data, a measure of likelihood for a frame to contain a stent is computed. Then, a robust binary representation of the presence of the stent in the pullback is obtained applying an iterative and multiscale quantization of the signal to symbols using the Symbolic Aggregate approXimation algorithm.
RESULTS:
The technique was extensively validated on a set of 103 IVUS of sequences of in vivo coronary arteries containing metallic and bioabsorbable stents acquired through an international multicentric collaboration across five clinical centers. The method was able to detect the stent position with an overall F-measure of 86.4%, a Jaccard index score of 75% and a mean distance of 2.5 mm from manually annotated stent boundaries, and in bioabsorbable stents with an overall F-measure of 88.6%, a Jaccard score of 77.7 and a mean distance of 1.5 mm from manually annotated stent boundaries. Additionally, a map indicating the distance between the lumen and the stent along the pullback is created in order to show the angular sectors of the sequence in which the malapposition is present.
CONCLUSIONS:
Results obtained comparing the automatic results vs the manual annotation of two observers shows that the method approaches the interobserver variability. Similar performances are obtained on both metallic and bioabsorbable stents, showing the flexibility and robustness of the method.
Keywords: IVUS; malapposition; stent; ultrasound
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Simone Balocco, Carlo Gatta, Xavier Carrillo, J. Mauri, & Petia Radeva. (2011). Plaque Type, Plaque Burden and Wall Shear Stress Relation in Coronary Arteries Assessed by X-ray Angiography and Intravascular Ultrasound: a Qualitative Study. In 14th International Symposium on Applied Sciences in Biomedical and Communication Technologies.
Abstract: In this paper, we present a complete framework that automatically provides fluid-dynamic and plaque analysis from IVUS and Angiographic sequences. Such framework is used to analyze, in three coronary arteries, the relation between wall shear stress with type and amount of plaque. Preliminary qualitative results show an inverse relation between the wall shear stress and the plaque burden, which is confirmed by the fact that the plaque growth is higher on the wall having concave curvature. Regarding the plaque type it was observed that regions having low shear stress are predominantly fibro-lipidic while the heavy calcifications are in general located in areas of the vessel having high WSS.
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Simone Balocco, Carlo Gatta, Oriol Pujol, J. Mauri, & Petia Radeva. (2010). SRBF: Speckle Reducing Bilateral Filtering. UMB - Ultrasound in Medicine and Biology, 36(8), 1353–1363.
Abstract: Speckle noise negatively affects medical ultrasound image shape interpretation and boundary detection. Speckle removal filters are widely used to selectively remove speckle noise without destroying important image features to enhance object boundaries. In this article, a fully automatic bilateral filter tailored to ultrasound images is proposed. The edge preservation property is obtained by embedding noise statistics in the filter framework. Consequently, the filter is able to tackle the multiplicative behavior modulating the smoothing strength with respect to local statistics. The in silico experiments clearly showed that the speckle reducing bilateral filter (SRBF) has superior performances to most of the state of the art filtering methods. The filter is tested on 50 in vivo US images and its influence on a segmentation task is quantified. The results using SRBF filtered data sets show a superior performance to using oriented anisotropic diffusion filtered images. This improvement is due to the adaptive support of SRBF and the embedded noise statistics, yielding a more homogeneous smoothing. SRBF results in a fully automatic, fast and flexible algorithm potentially suitable in wide ranges of speckle noise sizes, for different medical applications (IVUS, B-mode, 3-D matrix array US).
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Simone Balocco, Carlo Gatta, Marina Alberti, Xavier Carrillo, Juan Rigla, & Petia Radeva. (2012). Relation between plaque type, plaque thickness, blood shear stress and plaque stress in coronary arteries assessed by X-ray Angiography and Intravascular Ultrasound. MEDPHYS - Medical Physics, 39(12), 7430–7445.
Abstract: PMID 23231293
PURPOSE:
Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries.
METHODS:
First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound (IVUS) and Angiographic sequences, requiring minimal user interaction. Then, a computational pipeline allows to automatically assess fluid-dynamic and mechanical indices. Ten coronary arteries are analyzed illustrating the capabilities of the tool and confirming previous technical and clinical observations.
RESULTS:
The relations between the arterial indices obtained by IVUS measurement and simulations have been quantitatively analyzed along the whole surface of the artery, extending the analysis of the coronary arteries shown in previous state of the art studies. Additionally, for the first time in the literature, the framework allows the computation of the membrane stresses using a simplified mechanical model of the arterial wall.
CONCLUSIONS:
Circumferentially (within a given frame), statistical analysis shows an inverse relation between the wall shear stress and the plaque thickness. At the global level (comparing a frame within the entire vessel), it is observed that heavy plaque accumulations are in general calcified and are located in the areas of the vessel having high wall shear stress. Finally, in their experiments the inverse proportionality between fluid and structural stresses is observed.
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Simone Balocco, Carlo Gatta, Francesco Ciompi, Oriol Pujol, Xavier Carrillo, J. Mauri, et al. (2011). Combining Growcut and Temporal Correlation for IVUS Lumen Segmentation. In Jordi Vitria, Joao Miguel Raposo, & Mario Hernandez (Eds.), 5th Iberian Conference on Pattern Recognition and Image Analysis (Vol. 6669, pp. 556–563). LNCS. Berlin: Springer Berlin Heidelberg.
Abstract: The assessment of arterial luminal area, performed by IVUS analysis, is a clinical index used to evaluate the degree of coronary artery disease. In this paper we propose a novel approach to automatically segment the vessel lumen, which combines model-based temporal information extracted from successive frames of the sequence, with spatial classification using the Growcut algorithm. The performance of the method is evaluated by an in vivo experiment on 300 IVUS frames. The automatic and manual segmentation performances in general vessel and stent frames are comparable. The average segmentation error in vessel, stent and bifurcation frames are 0.17±0.08 mm, 0.18±0.07 mm and 0.31±0.12 mm respectively.
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Simone Balocco, Carlo Gatta, Francesco Ciompi, A. Wahle, Petia Radeva, S. Carlier, et al. (2014). Standardized evaluation methodology and reference database for evaluating IVUS image segmentation. CMIG - Computerized Medical Imaging and Graphics, 38(2), 70–90.
Abstract: This paper describes an evaluation framework that allows a standardized and quantitative comparison of IVUS lumen and media segmentation algorithms. This framework has been introduced at the MICCAI 2011 Computing and Visualization for (Intra)Vascular Imaging (CVII) workshop, comparing the results of eight teams that participated.
We describe the available data-base comprising of multi-center, multi-vendor and multi-frequency IVUS datasets, their acquisition, the creation of the reference standard and the evaluation measures. The approaches address segmentation of the lumen, the media, or both borders; semi- or fully-automatic operation; and 2-D vs. 3-D methodology. Three performance measures for quantitative analysis have
been proposed. The results of the evaluation indicate that segmentation of the vessel lumen and media is possible with an accuracy that is comparable to manual annotation when semi-automatic methods are used, as well as encouraging results can be obtained also in case of fully-automatic segmentation. The analysis performed in this paper also highlights the challenges in IVUS segmentation that remains to be
solved.
Keywords: IVUS (intravascular ultrasound); Evaluation framework; Algorithm comparison; Image segmentation
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Simon Jégou, Michal Drozdzal, David Vazquez, Adriana Romero, & Yoshua Bengio. (2017). The One Hundred Layers Tiramisu: Fully Convolutional DenseNets for Semantic Segmentation. In IEEE Conference on Computer Vision and Pattern Recognition Workshops.
Abstract: State-of-the-art approaches for semantic image segmentation are built on Convolutional Neural Networks (CNNs). The typical segmentation architecture is composed of (a) a downsampling path responsible for extracting coarse semantic features, followed by (b) an upsampling path trained to recover the input image resolution at the output of the model and, optionally, (c) a post-processing module (e.g. Conditional Random Fields) to refine the model predictions.
Recently, a new CNN architecture, Densely Connected Convolutional Networks (DenseNets), has shown excellent results on image classification tasks. The idea of DenseNets is based on the observation that if each layer is directly connected to every other layer in a feed-forward fashion then the network will be more accurate and easier to train.
In this paper, we extend DenseNets to deal with the problem of semantic segmentation. We achieve state-of-the-art results on urban scene benchmark datasets such as CamVid and Gatech, without any further post-processing module nor pretraining. Moreover, due to smart construction of the model, our approach has much less parameters than currently published best entries for these datasets.
Keywords: Semantic Segmentation
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